Angiotensin II receptors and cancer

Our research is also focused on the clarification of the role of angiotensin II and its signaling in tumorigenesis in the colon, lung, and pancreas. Currently, the following studies are in progress: a) determination of whether pharmacological and/or genetic intervention (up-regulation of angiotensin II type 2 receptor function) attenuate chemical carcinogen-induced tumorigenesis in the lung (Kanehira et al., 2005), pancreas (Doi et al., 2010) and colon (Takagi et al., 2002); b) investigation of whether a positive or negative correlation exists between angiotensin II receptor gene polymorphisms and human lung cancer in lung cancer patients and corresponding normal control subjects.

Immunohistochemical expression of Ang II receptors