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College of Veterinary Medicine

Masaaki Tamura

Dr. TamuraProfessor

DVM, 1973, Kitasato University College of Veterinary Medicine, Japan
PhD, 1980, Veterinary Medicine (Biochemistry & Nutrition), Azabu Veterinary College, Japan

Coles Hall 210
Phone: 785-532-4825
Email: mtamura@vet.k-state.edu

Research Interests

Cancer is one of the most devastating diseases in the world and is the second leading cause of death in the United States. Despites significant effort to find cures for cancer, such as pancreatic, lung and ovarian, curative therapy still remain elusive. These three types of cancers contribute to more than 42% of overall cancer-related deaths.

The Tumor Physiology Laboratory directed by Dr. Masaaki Tamura, a member of The Johnson Cancer Research Center, aims to find cures for cancers by studying cancer cell-targeted nanoparticle-based gene therapy, metastatic tumor-targeted stem cell therapy, and diet-based alternative medicine for cancer immune therapy/prevention. The core concept of Dr. Tamura's research is to develop non-invasive host-friendly effective therapies. Dr. Tamura's research laboratory discovered that umbilical cord Warton's jelly (matrix) derived stem cells, first identified in the Kansas State University College of Veterinary Medicine, can migrate to cancer tissue specifically and kill various cancer cells including breast, lung and pancreatic cancers. His research team also discovered that selective peptide nanoparticles are an exceptionally good gene delivery tool in cancer animal models and this particle-dependent gene therapy markedly attenuated lung cancer growth in mice. Dr. Tamura's lab is committed to contributing to the ongoing research for finding curative therapies to help in the fight against this difficult disease.

More information regarding Dr. Tamura's research can be found by following the links below:



Original papers: 

1.     Tsuruki, F., Wung, H.L., Tamura, M., Shimura, F., Moriuchi, S., and Hosoya, N. The effect of dietary calcium and vitamin D3 on the cadmium accumulation in the tissues. Vitamins, 52: 161-166, 1978. 

2.     Shimura, F., and Tamura, M. Application of normal hen intestinal cytosol for the radioreceptor assay of serum 1,25-dihydroxycholecalciferol concentration. Vitamins, 52: 173-181, 1978. 

3.     Tamura, M., and Sugiura, K. The study of vitamin D3 metabolism in dairy cows with special reference to serum levels of vitamin D3 metabolites. Jpn. J. Vet. Sci., 41: 377-384, 1979.

4.     Hosoya, N., Tamura, M., and Oku, T.  Purification and characterization of calcium-binding protein from bovine milk.  Proceedings of the International Symposium on Calcium-Binding Proteins and Calcium Function in Health and Disease.  Madison, Wisconsin, 489-490, 1980. 

5.     Moriuchi, S., Tamaki, Y., Mizuno, K., Tamura, M., Shidoji, Y., and Hosoya, N. Intestinal vitamin D-dependent calcium binding protein in the chicks having different plasma alkaline phosphatase variants.  Vitamins, 55: 179-184, 1981. 

6.     Tamura, M., and Oku, T. Purification and characterization of calcium-binding protein from bovine milk. Jpn. J. Vet. Sci., 43: 539-592, 1981. 

7.     Tamura, M., Oku, T. and Hosoya, N. Calmodulin-like function of calcium-binding protein in bovine milk. J. Nutr. Sci. Vitaminol., 27: 489-492, 1981. 

8.     Tamura, M., Oku, T., and Hosoya, N. Calcium-binding protein in bovine milk:  calcium-binding properties and amino acid composition. J. Nutr. Sci.  Vitaminol. 28: 553-541, 1982. 

9.     Tamura, M. Relationship of serum vitamin D3 metabolites and mineral levels during puerperium in dairy cow. J. Jpn. Vet. Med. Assoc. 36: 78-81, 1983. 

10.   Tamura, M., Kuwano, H., Kinoshita, T., and Inagami, T. Identification of  linoleic and oleic acids as endogenous Na+, K+-ATPase inhibitors from acute volume-expanded hog plasma. J. Biol. Chem. 260: 9672-9677, 1985. 

11.   Tamura, M., Inagami, T., Kinoshita, T., and Kuwano, H.  A search for endogenous Na+, K+-ATPase inhibitor in acutely volume-expanded hog plasma led to lysophosphatidylcholine-stearoyl.  J. Hypertension 5: 219-225, 1987. 

12.   Takayanagi, R., Snajdar, R.M., Imada, T., Tamura, M., Pandey, K.N., Misono, K.S., and Inagami, T.  Purification and characterization of two types of atrial natriuretic factor receptors from bovine adrenal cortex:  guanylate cyclase-linked and cyclase-free receptors.  Biochem. Biophys. Res. Commun. 144: 244-250, 1987. 

13.   Tamura, M., Harris, T.M., Higashimori, K., Sweetman, B.J., Blair, I.A., and Inagami, T.  Lysophosphatidylcholines containing polyunsaturated fatty acids were found as Na+, K+-ATPase inhibitors in acutely volume-expanded hog.  Biochemistry 26: 2797-2806, 1987. 

14.   Takayanagi, R., Inagami, T., Snajdar, R.M., Imada, T., Tamura, M. and Misono, K.S.  Two distinct forms of receptor for atrial natriuretic factor in bovine adrenocortical cells:  purification, ligand binding, and peptide mapping.  J. Biol. Chem. 252: 12104-12113, 1987. 

15.   Inagami, T. and Tamura, M.  Identification of unsaturated fatty acids and  lysophosphatidylcholines as Na+, K+-ATPase inhibitor in acutely volume-expanded hog.  Symposium on Ion Transport and Natriuresis:  Canessa, Dzau and Horan (Eds.).  Hypertension 10: Suppl. I. (I-108-I-112), 1987. 

16.   Inagami, T. and Tamura, M.  Approach to endogenous Na, K-ATPase inhibitors.  Koketsuatsu (Hypertension) 10: 1-2, 1987. 

17.   Tamura, M., Lam, T.-T., and Inagami, T.  Specific endogenous Na, K-ATPase inhibitor purified from bovine adrenal.  Biochem. Biophys. Res. Commun. 149: 468-474, 1987. 

18.   Tamura, M., Lam, T.-T. and Inagami, T.  Isolation and characterization of a specific endogenous Na+, K+-ATPase inhibitor from bovine adrenal.  Biochemistry 27: 4244-4253, 1988. 

19.   Inagami, T. and Tamura, M.  Purification and characterization of specific endogenous ouabain-like substance from bovine adrenal.  Am. J. Med. Sci. 295: 400-405, 1988. 

20.   Tamura, M., Konishi, F. and Inagami, T.  A novel endogenous Na-pump inhibitor in pig urine:  Purification and comparison with the inhibitor purified from bovine adrenal glands.  J. Cardiovascul. Pharmacol. 22: 547-550, 1993. 

21.   Tamura, M., Harris, T.M., Konishi, F. and Inagami, T.  Isolation and characterization of an endogenous Na+, K+-ATPase specific inhibitor from pig urine.  Eur. J. Biochem. 211: 317-327, 1993. 

22.   Tamura, M., Naruse, M., Sakakibara, M. and Inagami, T.  Isolation of an endogenous Na-pump specific inhibitor from normal pig urine:  characterization and comparison with the inhibitor purified from bovine adrenal glands.  Biochem. Biophys. Acta. 1157: 15-22, 1993. 

23.   Tamura, M., Harris, T.M., Lam, S.-K., Phillips, D., Blair, I.A., Wang, Y., Hellerqvist, C., Naruse, M. and Inagami, T.:  Endogenous Na+-pump inhibitors in rats: Distribution, identification and physiological significance.  Ther. Res. 15: 223-232, 1994. 

24.   Naruse, K., Naruse, M., Tanabe, A., Yoshimoto, T., Watanabe, Y., Kurimoto, F., Horiba, N., Tamura, M., Inagami, T. and Demura, H.:  Does plasma immunoreactive ouabain originate from the adrenal glands?  Hypertension, 23: 102-105, 1994. 

25.   Tamura, M., Harris, T.M., Phillips, D., Blair, I.A., Wang, Y., Hellerqvist, C., Lam, S.-K. and Inagami, T.:  Identification of two cardiac glycosides as Na+-pump inhibitors from rat urine and diet.  J. Biol. Chem. 269: 11972-11979, 1994. 

26.   Tamura, M., Piston, D.W., Tani, M., Landon, E.J., Naruse, M. and Inagami, T.:  Ouabain increases aldosterone release through stimulation of the local renin-angiotensin system in bovine adrenal glomerulosa cells.  Am. J. Physiol. 270: E27-E35, 1996. 

27.   Tamura, M., Landon, E.J., and Inagami, T.: Na+, K+-ATPase inhibitors in rat urine: origins and physiological significance. Clin. Exp. Hypertens. 20: 543-550, 1998. 

28.   Stoneking, B.J., Hunley, T.E., Nishimura, H., Ma, J., Fogo, A.B., Inagami, T., Tamura, M., Adams, M.C., Brock, J.W. III, and Kon, V.: Renal angiotensin converting enzyme promotes renal damage during uretheral obstruction. J. Urol. 160:1070-1074, 1998. 

29.   Tamura, M., Wanaka, Y., Landon, E.J., Inagami, T.: Intracellular sodium modulates the expression of angiotensin II subtype 2 receptor in PC12W cells.  Hypertension 33: 626-632 1999. 

30.  MacMillan L.B., Bass, M.A., Cheng, N., Howard, E.F., Tamura, M., Strack, S.S., Wadzinski, B.E., Colbran, R.J.: Brain actin-associated protein phosphatase 1 holoenzymes containing spinophilin, neurabin and selected catalytic subunit isoforms. J.Biol.Chem. 274:35845-35854, 1999. 

31.   Tamura, M., Chen, Y.-J., Howard, E.F., Tanner, M., Landon, E.J., Myers, P.R. Lipopolysaccharides and cytokines downregulate the angiotensin II type 2 receptor in rat cardiac fibroblasts. Eur. J. Pharmacol. 386:289-295, 1999. 

32. Hunley, T.E., Tamura, M., Stoneking, B., Nishimura, H., Inagami T., and Kon, V.: The angiotensin receptor type 2 (AT2) tonically inhibits the angiotensin converting enzyme. Kid. Int., 57:570-577, 2000. 

33. Tamura, M., Utsunomiya, H., Nakamura, M., Landon  E.J.: Effect of dietary cardiac glycosides on blood pressure regulation in rats.  Can. J. Physiol. Pharmacol., 78:548-556, 2000. 

34. Tamura, M., Takagi, T., Howard, E.F., Landon, E.J., Steimle, A., Tanner, M. and Myers, P.R.: Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats. J. Hypertens., 18:1238-1246, 2000. 

35. Takaya, J., Matsusaka, T., Katori, H., Tamura, M., Miyazaki, Y., Homma, T., Ichikawa, I.: In situ demonstration of angiotensin-dependent and independent pathways for hyperaldosteronism during chronic extracellular fluid volume depletion. Mol. Endocrinol. 15: 2229-2235, 2001. 

36.   Sato, H., Tachifuji, A., Tamura, M., Miyakawa, I.: Identification of YMN-1 antigen protein and biochemical analyses of protein components involved in the mitochondrial nucleoid fraction of the yeast Sacchromyces cerevisea. Protoplasma 219: 51-56, 2002. 

37.   Takagi, T., Nakano, Y., Takekoshi, S., Inagami, T. and Tamura, M. Hemizygous mice for the angiotensin II type 2 receptor gene have attenuated susceptibility to azoxymethane-induced colon tumorigenesis. Carcinogenesis 23, 1235-1241, 2002. 

38. Utsunomiya, H., Takekoshi, S., Takagi, T., Nakano, Y., Senbonmatsu, T., Nakamura, M., Kakudo, K., Inagami, T. and Tamura, M.: Development of angiotensin II type-2 receptor antibodies in AT2 receptor-knockout mice. Regulatory Peptides 126: 155-161, 2005. 

39. Kanehira, T., Tani, T., Takagi, T., Nakano, Y., Howard, E.F., Tamura, M.: Angiotensin II type 2 receptor gene deficiency attenuates susceptibility to tobacco-specific nitrosamine-induced lung tumorigenesis: Involvement of TGF-b-dependent cell growth attenuation. Cancer Res. 65:7660-7665, 2005. 

40. Rachakatla, R., Marini, F., Martinez, M., Miller, E. Tamura, M. and Troyer, D.: Development of human umbilical cord matrix stem cell-based therapy for experimental lung tumors. Cancer Gene Ther. 14:828-835, 2007. 

41. Rachakatla, R., Pyle, M., Edwards, S., Marini, F., E., Weiss, M. L., Tamura, M. and Troyer, D.: Combination treatment of human umbilical cord matrix stem cell-based interferon-beta gene therapy and 5-Fluorouracil significantly reduces growth of human breast cancer in SCID mouse lungs. Cancer Invest, 26:662-670, 2008. 

42. Ganta, C., Shi, A., Battina, S. K., Pyle, M., Sandeep Rana, S., Hua, D.H., Tamura, M. and Troyer, D.: Combination of Nanogel Polyethylene glycol-Polyethylenimine and 6-(hydroxymethyl)-1, 4- anthracenedione as an Anticancer Nanomedicine.  J. Nanosci. Nanotechnol. 8:2334-2340, 2008. 

43. Tani, T., Ayuzawa, R., Takagi, T., Kanehira, T., Maurya, D. and Tamura, T.: Angiotensin II bi-directionally regulates cyclooxygenase-2 expression in intestinal epithelial cells. Mol. Cell. Biochem. 315:185-193, 2008. 

44. Tamura, M, Yun, H-P., Edls, J., Kanehira, T., Takekoshi, S., Oursler, S., Chard-Bergstrom, C., Andrews, G and Mernaugh, R.: Specific single chain variable fragment (ScFv) antibodies to angiotensin II AT2 receptor: evaluation of the angiotensin II receptor expression in normal and tumor-bearing mouse lung. J. Mol. Histol. 39:351-358, 2008. 

45. Matsuzuka, T., Miller, K., Pickel, L., Tani, T., and Tamura, M.: The synergistic induction of cyclooxygenase-2 in lung fibroblasts by angiotensin II and pro-inflammatory cytokines. Mol. Cell. Biochem. 320:163-171, 2009. 

46. Ganta, C., Doi, C., Ayuzawa, R., Rachakatla, R., Pyle, M., Andrews, G., Weiss, M., Tamura, M. and Troyer, D.: Rat Umbilical Cord Stem Cells Completely Abolish Rat Mammary Carcinomas with No Evidence of Metastasis or Recurrence 100 Days Post-tumor cell Inoculation. Cancer Res. 69:1815-1820, 2009. 

47. Ayuzawa, R., Doi, C., Rachakatla, R., Pyle, M., Troyer, D. and Tamura, M.: Naïve human umbilical cord matrix derived stem cells significantly attenuate growth of human breast cancer cells in vitro and in vivo. Cancer Lett. 280:31-37, 2009. 

48. Pickel, L., Matsuzuka, T., Doi, C., Ayuzawa, R., Maurya, D., Xie, S-X., Berkland, C., Tamura, M.Over-expression of angiotensin II type 2 receptor gene induces cell death in lung adenocarcinoma cells. Cancer Biol. Ther. 9:277-285, 2010. 2010 Impact Factor: 2.907 

49. Doi, C., Maurya, D., Ayuzawa, R., Pyle, M., Troyer, D. and Tamura, M.: Cytotherapy with naive rat umbilical cord matrix derived stem cells significantly attenuates growth of murine pancreatic cancer cells and increases mouse survival in syngeneic mice. Cytotherapy 12:408-417, 2010. 2010 Impact Factor: 2.925 

50. Matsuzuka, T., Rachakatla, R., Doi, C., Maurya, D., Ohta, N., Kawabata, A., Pyle, M., Pickel, L., Reischman, J., Pickel, L., Marini, F., Troyer, D., and Tamura, M.:   Human umbilical cord matrix–derived stem cells transfected with interferon-β gene significantly attenuated bronchioloalveolar carcinoma xenografts in SCID mice. Lung Cancer, 70:28-36, 2010. 2010 Impact Factor : 3.356 

51. Doi, C., Egashira, N., Kawabata, A., Maurya, D., Ohta, N., Uppalapati, D., Ayuzawa, R., Pickel, L., Isayama, Y., Troyer, D., Takekoshi, S. and Tamura, M.: Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice. BMC Cancer, 10:67, 2010. 2010 Impact Factor : 3.153 

52. Balivada, S., Rachakatla, R., Wang, W., Samarakoon, T., Dani, R., Pyle, M., Kroh, F., Walker, B., Leaym, X., Koper, O., Tamura, M., Chikan, V., Bossmann, S., Troyer, D.: A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles: a mouse study. BMC Cancer, 10:119, 2010. 2010 Impact Factor : 3.153 

53. Maurya, D., Doi, C., Kawabata, A., Pyle, M., King, K., Wu,Z., Troyer, D. and Tamura, M.: Therapy with un-engineered naïve rat umbilical cord matrix stem cells markedly inhibits growth of murine lung adenocarcinoma. BMC Cancer, 10:590, 2010. 2010 Impact Factor : 3.153 

54. Rachakatla, R., Balivada, S., Seo, G-M., Myers, C., Wang, H., Samarakoon, T., Dani, R., Pyle, M., Kroh, F., Walker, B., Leaym, X., Koper, O., Chikan, V., Bossmann, S., Tamura, M., Troyer, D.: Attenuation of mouse melanoma by A/C magnetic field after delivery of bi-magnetic nanoparticles by neural stem cells. ACS Nano, 4: 7093-7104, 2010. Impact Factor: 9.855 

55. Maurya, D., Doi, C., Pyle, M., Rachakatla, R., Davis, D., Tamura, M. and Troyer, D.: Non-random tissue distribution of naïve human umbilical cord matrix stem cells. World J Stem Cells, 3:1-8, 2011. PMID:21607135 [PubMed] PMCID:PMC3097938 Impact Factor: 1.000 

56. Maurya, D., Ayuzawa, R., Doi, C., Troyer, D. and Tamura, M.: Topoisomerase I inhibitor SN-38 effectively attenuates growth of human non-small cell lung cancer cell lines in vitro and in vivo. J Environ Pathol Toxicol Oncol, 30:1-10, 2011. PMID:21609311 [PubMed - indexed for MEDLINE] PMCID:PMC3133571 Impact Factor: 1.000 

57. Seo, G-M., Rachakatla, R., Pyle, M., Shrestha, T., Tamura, M., Bossmann, S., Troyer, D.: A Self-Contained Enzyme Activating Prodrug Cytotherapy for Preclinical Melanoma. Mol Biol Rep, 39:157-165,2012, Epub 2011 May 13. PMID: 21567204, PMCID: PMC3222711 Impact Factor: 2.929 

58. Uppalapati, L., Ohta, N., Zhang, Y., Kawabata, A., Pyle, M., Becker, K. G., Troyer, D., andTamura, M.: Screening and characterization of unique tumoricidal genes in rat umbilical cord matrix stem cells. Mol Pharmaceutics, 8:1549-1558, 2011. PMID:21851062 [PubMed- indexed for MEDLINE] PMCID:PMC3202613 Impact Factor: 4.782 

59. Basel, M., Balivada, S., Shrestha, T., Seo, G-M., Myers, C., Pyle, M., Tamura, M., Bossmann, S., Troyer, D.:  A Cell-Delivered and -Activated SN38-Dextran Prodrug Increases Survival in a Murine Disseminated Pancreatic Cancer Model. Small, 8:913-920, 2012. PMID:22238072, Impact Factor: 7.823 

60. Basel, M., Balivada, S., Wang, H., Shrestha, T., Seo, G-M., Pyle, M., Abayaweera, G., Dani, R., Koper, O., Tamura, M., Chikan, V., Bossmann, S., Troyer, D.:  Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model. Intnl J Nanomed, 7:297-306, 2012. PMID:22287840,  PMCID:PMC3265998 Impact Factor: 3.463 

61. Kawabata, A., Baoum, A., Ohta, N., Jacquez, S., Berkland, C., and Tamura, M.: A novel cationic nanoparticle-based gene therapy with angiotensin II type 2 receptor significantly attenuates growth of lung adenocarcinoma grafts in immune competent mice. Cancer Res, 72:2057-67. 2012, Epub 2012 Mar 2. PMID:22389453  Impact Factor: 8.650 

62. Kawabata, A., Matsuzuka, T., Doi, C., Seiler, G., Reischman, J., Pickel, L., Ayuzawa, R., Nguyen, T., and Tamura, M.: C1B domain peptide of protein kinase Cg significantly suppresses growth of human colon cancer cells in vitro and in an in vivo mouse xenograft model through induction of cell cycle arrest and apoptosis. Cancer Biol Ther. 13:880-889, 2012. PMID:22785210, PMCID:PMC3414411 Impact Factor: 3.287 

63. Kawabata, A., Ohta, N., Seiler, G., Pyle, M., Ishiguro, S., Zhang, Y., Becker, K. G., and Tamura, M.: Naïve rat umbilical cord matrix stem cells significantly attenuates mammary tumor growth through modulation of an endogenous immune responses to the tumors. Cytotherapy, 15:586-597, 2013. PMID:23474329, PMCID:PMC3652627 Impact Factor: 3.100 

64. Magnani, F., Pappas, C.G., Crook, T., Magafa, V., Cordopatis, P., Ishiguro, S., Ohta, N., Selent, J., Bosnyak, S., Jones, E. S., Gerothanassis, I. P., Tamura, M., Widdop, R. E., Tzakos, A. G.: Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II. ACS Chem Biol, 2014. May 14. [Epub ahead of print] PMID: 24787922 Impact Factor: 5.331 

65. Ishiguro, S., Yoshimura, K., Takao, S., Kawabata, A., Wall, T., Tsunedomi, T., Oka, M., Inui, M., Pappas, C., Tzakos, A.G., and Tamura, M. , Involvement of an angiotensin II type 2 receptor (AT2R) signaling in human pancreatic ductal adenocarcinoma (PDAC): a novel AT2R agonist effectively attenuates growth of PDAC grafts in mice. Cancer Biol Ther, 16:308-17, 2015. PMID: 25756513 Impact Factor: 3.072 

66. Ohta, N., Ishiguro, S., Kawabata, A., Uppalapati, L., Ball, J., Pyle, M., Troyer, D., De, S., Zhang, Y., Becker, K., andTamura, M.: Human umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes. PLoS One,10:e0123756, 2015. PMID: 25942583, PMCID: PMC4420498 Impact Factor: 3.234 

67. Alhakamy, N*. A., Ishiguro, S.*, Uppalapati, D., Berkland, C. J., and Tamura, M.: AT2R gene delivered by condensed polylysine complexes attenuates lewis lung carcinoma after intravenous injection or intratracheal spray. Mol Cancer Ther, 2015 Dec 4. pii: molcanther.0448.2015. [Epub ahead of print] PMID: 26637367, *, Co-first authors. Impact Factor: 5.683  

68. Ishiguro, S.*, Cai, S.*, Uppalapati, D., Turner, K., Zhang, T., Forrest, C.W., Forrest, M.F., and Tamura,T.: Intratracheal administration of hyaluronan-cisplatin conjugate nanoparticle significantly attenuates lung cancer growth in mice. Pharm Res, 33(10):2517-29, 2016, PMID: 27335023, *, Co-first authors. 

69. Ishiguro, S.*, Alhakamy, N.A.*, Uppalapati, D., Delzeit, J., Berkland, C., Tamura, M.: A combination delivery with an intravenous injection and an intratracheal aerosol spray of AT2R gene by modified TAT peptide nanoparticles attenuates human bronchioloalveolar carcinoma xenografts in immunodeficient mice. Mol Pharm accepted 2016. *, Co-first authors. 

70. Ishiguro, S., Uppalapati, D., Goldsmith, Z., Robertson, D., Hodge, J., Holt, H., Nakashima, A., Turner, K., and Tamura, T.: Expolysaccharides extracted from parachlorella kessleri inhibit colon carcinoma growth in mice via stimulation of host antitumor immune responses. PlosS One. 12: e0175064, 2017, PMID: 28380056, PMCID: PMC5381895

71. Ishiguro, S., Kawabata, A., Ohta, N., Uppalapati, L., Rojas, A., Monson, K., Tzakos, A.G., and Tamura, M.: Co-treatment with a C1B5 peptide of protein kinase Cγ and a low dose of gemcitabine strongly attenuated pancreatic cancer growth in mice through T cell activation. Biochem Biophys Res Commun, 291:32280-5, 2017. PMID: 29155177

72. Ishiguro, S., Robben, N., Burghart, R., Cote, P., Greenway, S., Thakkar, R., Upreti, D., Nakashima, A., Suzuki, K., Comer, J., and Tamura, M. Water extract from Chlorella sorokiniana cell membrane fraction enhances host antitumor immune responses and inhibit colon carcinoma growth in mice. Integr Cancer Ther, 19, 2020, PMID: 32009489

73. Ishiguro, S., Upreti, D., Robben, N., Burghart, R., Loyd, M., Ogun, D., Le, T., Delzeit, D., Nakashima, A., Thakkar, R., Nakashima, A., Suzuki, K., Comer, J., and Tamura, M. Water extract from Euglena gracilis prevents lung carcinoma growth in mice by attenuation of the myeloid-derived cell population. Biomed Pharmacother, 127:110166, 2020, PMID: 32361165


1. Tamura, M., Kawabata, Ohta, N., Uppalapati, L., Becker, K. G., and Troyer, D.: Wharton’s jelly stem cells as agents for cancer therapy. Accepted in Open Tissue Engineering Regenerative Med J, 4:39-47, 2011

Books & Chapters: 

1. Tamura, M.: Biochemistry dictionary 1st Ed., sections for vitamin A, vitamin D, 25-OH-vitamin D3, 1, 25-(OH)2-vitamin D3, vitamin E, Placenta, Tokyo-kagaku-dojin press, 1983 

2.     Tamura, M., Harris, T.M., Lam, S.-K. and Inagami, T.:  Identification and physiological significance of Na+/K+-pump inhibitors in rats.  Eds. Banberg, E. and Schoner, W. The Sodium pump: Structure mechanism, hormonal control and its role in disease.  pp743-754, 1994. 

3.     Tamura, M., Konishi, F., Sakakibara, M. and Inagami, T.:  Large scale purification of an endogenous Na+/K+-pump inhibitor from bovine adrenal glands.  Eds. Banberg, E. and Schoner, W. The Sodium pump: Structure mechanism, hormonal control and its role in disease.  pp763-766, 1994. 

4.     Tamura, M., and Matsuzuka, T.: Encyclopedia of Cancer 2nd Ed., section for angiotensin II signaling, Springer, 2007 

5.    Tamura, M., Troyer, D., Maurya,D.K.,Kawabata, A., and Rachakatla, R.: Modern Insights Into Disease From Molecules to Man: Cytokines, Ed Preedy, V.R. Chapter for Cytokine and Lung cancer, Science publishers,pp1-27, 2010 

6.   Kawabata, A., Ohta, N., Uppalapati, D., Ishiguro, S., Pyle, M., Troyer, D., and  Tamura, M.: Rats in cancer research: naïve rat umbilical cord matrix stem cells exhibit strong tumoricidal activity in multiple organ type cancers. Chapter for The Rat in Cancer Research: A Crucial Tool for all Aspects of Translational Studies, pp1-27, Editor: Daniel L. Pouliquen, Research Signpost,2012 

7.   Ohta, N., Kawabata, A., Uppalapati, D., Ishiguro, S., Troyer, D., and Tamura, M.: Cytotherapy for breast cancer by umbilical cord matrix stem cells. Stem Cell Therapeutics for Cancer, Editor: Khalid Shah, Wiley publisher,pp111-126, 2013 Print ISBN: 9781118282427, Online ISBN: 9781118660423