Nancy Monteiro-Riviere

Dr. Monteiro-Riviere's research interests include nanotoxicology, percutaneous absorption of topically applied drugs, chemicals and nanoparticles, dermal absorption and cutaneous toxicology of chemical mixtures, and transdermal drug delivery. Most recent interests are the impact of engineered nanomaterials on human health and the environment. This research begins to assess the nature of interaction between manufactured/engineered nanoparticles and the skin; including dermal absorption, cutaneous toxicity as well as the ability to distribute to the skin after systemic exposure. These studies include cadmium selenide quantum dots, fullerenes, single and multi-walled carbon nanotubes, silver, aluminum, titanium dioxide, zinc oxide, different formulations of sunscreens, and other nanoparticles that are representative of the broad spectrum of nanoparticles presently being used by industry and the consumer. Our laboratory will provide boundaries of a dermal risk assessment for manufactured nanomaterials (MNM) exposure. Another interest along with colleagues is to develop a biologically-relevant metric of the potential for MN to interact with biological systems. We term this the Biological Surface Adsorption Index (BSAI). Our hypothesis is that different degrees of particle agglomeration or interactions with proteins in exposure media will result in markedly different BSAI that will correlate to altered cellular uptake or biodistribution under similar exposure conditions. We will characterize and identify proteins that nanomaterials interact with through proteomic analysis, and determine any material-specific patterns. Currently, we are studying the biological effects and cellular uptake processes of MNM using a well-characterized in vitro cell line, the human epidermal keratinocyte (HEK). Knowledge of biodistribution of nanomaterials in an isolated perfused skin model will provide data that could be used to predict tissue distribution after systemic exposure. A capstone analysis will be conducted correlating the relationship between the parameters defined from the conditions above. Specifically, the relation of different BSAI of the MNM studied relative to HEK or uptake in perfused skin will shed light on the usefulness of this parameter as compared to traditional methods of characterization (concentration, charge density, particle number distributions, and hydrophobicity).

Narayan RJ, Boehm RD, Monteiro-Riviere NA. Cell and Protein Interactions with Diamond. In Handbook of Clinical Medicine-Law, Business, Regulation, Safety and Risk, (Eds. Bawa R, Audette G, Reese BE), Vol.11, Section III-Health, Safety, Risk and Biological Interactions, Pan Stafford Publishing, Singapore, Chapter 33, pp.809-822, 2016.

Monteiro-Riviere NA. Safety of Nanoparticle Skin Penetration. In Percutaneous Penetration Enhancers-Chemical Methods in Penetration Enhancement-Nanocarriers Series(Eds. Dragicevic N and Maibach HI), Springer-Verlag Publishers, Heidelberg, Germany, Vol. 2, Chapter 24, pp. 363-376, 2016.

Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Toxicological effect of pet food ingredients on canine bone marrow derived mesenchymal stem cells and enterocyte-like cells. Journal Applied Toxicology 36 (2): 189-198, 2016.

Lin Z, Monteiro-Riviere NA, Kannan R, Riviere JE. A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles. Nanomedicine 11(2):107-119, 2016.

Choi K, Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Oxidative stress response in canine in vitro liver, kidney, and intestinal models with seven potential dietary ingredients. Toxicology Letters 241:49-59, 2016.

Choi K, Koci J, Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Mechanistic toxicity assessment of hexahydroisohumulone in canine hepatocytes, renal proximal tubules, bone marrow-derived mesenchymal stem cells and enterocyte-like cells. International Journal of Veterinary Health Science and Research (IJVHSTR) 4 (2): 88-103, 2016.

Lin Z, Monteiro-Riviere NA, Riviere JE. A physiologically based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice. Nanotoxicology 10 (2): 162-172, 2016.

Williams FM, Rothe H, Barrett G, Chiodini A, Whyte J, Cronin MT, Monteiro-Riviere NA, Plautz J, Roper C, Westerhout J, Yang C, Guy RH. Assessing the safety of cosmetic chemicals: consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral Threshold of Toxicological Concern (TTC). Regulatory Toxicology and Pharmacology 76:174-186, 2016.

Chen D, Monteiro-Riviere NA, Zhang LW. Intracellular imaging of metallic nanoparticles with associated endocytic pathways. WIREs Nanomedicine and Nanobiotechnology doi: 10.1002/wnan.1419

Chen R, Zhang Y, Monteiro-Riviere NA, Riviere JE. Quantification of nanoparticle pesticide absorption: computational approaches based on experimental data. Nanotoxicology 10 (8):1118-1128, 2016.

Sasidharan A, Chandran P, Monteiro-Riviere NA. Biocorona bound gold nanoparticles augments their hematocompatibility irrespective of size or surface charge. ACS Biomaterials Science and Engineering 2 (90), 1608-1618, 2016.

Sahneh FD, Scoglio CM, Monteiro-Riviere NA, Riviere JE. Predicting the impact of biocorona formation kinetics on interspecies extrapolations of nanoparticle biodistribution modeling. Nanomedicine (Lond.) 10:25-33, 2015.

Monteiro-Riviere NA, Riviere JE. Dermatotoxicity of Nanomaterials. In Handbook of Safety Assessment of Nanomaterials: From Toxicological Testing to Personalized Medicine. (Ed. Fadeel B.), Pan Stamford Press, Chapter 15, pp. 439-459, 2015.

Shirwaiker RA, Samberg ME, Cohen PH, Wysk RA, Monteiro-Riviere NA. Nanomaterials and synergistic low intensity direct (LIDC) stimulation technology for orthopaedic implantable medical devices. Wires Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology5(3): 191-204, 2013.

Monteiro-Riviere NA, Samberg ME, Oldenburg SJ, Riviere. Protein binding modulates the cellular uptake of silver nanoparticles into human cells: Implications for in vitro to in vivo extrapolations. Toxicology Letters220(3):286-293, 2013

Koci J, Jeffery B, Riviere JE, Monteiro-Riviere NA. In vitro safety assessment of food ingredients in canine renal proximal tubule cells. Toxicology In Vitro 29:289-298, 2015.

Sasidharan A, Riviere JE, Monteiro-Riviere NA. Gold and silver nanoparticle interaction with human proteins: Impact and implications in biocorona formation. Journal of Materials Chemistry B 3:2075-2082, 2015.

Lin Z, Monteiro-Riviere NA, Riviere JE. Pharmacokinetics of metallic nanoparticles. WIREsNanomedicine and Nanobiotechnology 7:189-217, 2015.

Zhang LW, Koci J, Jeffery B, Riviere JE, Monteiro-Riviere NA. Safety assessment of potential food ingredients in canine hepatocytes. Food and Chemical Toxicology 78:105-115, 2015.

Sasidharan A, Monteiro-Riviere NA. Biomedical applications of gold nanomaterials: opportunities and challenges. WIREs Nanomedicine and Nanobiotechnology 7:779-796, 2015.

Monteiro-Riviere NA, Ortega MT, Choi K, Koci J, Lin Z, Jeffery B, Riviere JE. Comparative in vitro cytotoxicity of 20 potential food ingredients in canine liver, kidney, bone marrow-derived mesenchymal stem cells and enterocyte-like cells. Applied in Vitro Toxicology 1(4): 276-288, 2015.

Samberg ME, Monteiro-Riviere NA. In Vitro and In Vivo Toxicity and Pharmacokinetics of Silver Nanoparticles. In Encyclopedia of Nanotechnology (Ed. Bhushan, B.). Springer Science and Business Media, Dordrecht, pp.1-14, 2015.

Samberg ME, Mente P, He T, King MW, Monteiro-Riviere NA. In vitro biocompatibility and antibacterial efficacy of degradable poly (L-lactide-co-epsilon-caprolactone) copolymer incorporated with silver nanoparticles. Annals of Biomedical Engineering 42(7): 1482-1493, 2014

Monteiro-Riviere NA and Tran CL (Editors). Second Edition. Nanotoxicology: Progress toward Nanomedicine, CRC Press, Boca Raton, Florida. March 2014. BOOK

Hall RA, George SM, Kim YE, Hwang W, Samberg ME, Monteiro-Riviere NA, Narayan RJ. Growth of zircone on nanoporous alumina using molecular layer deposition. JOM: The Journal of the Minerals, Metals & Materials Society. 66:649-654, 2014.

Riviere JE, Monteiro-Riviere NA. Dermal Exposure and Absorption of Chemicals and Nanomaterials. In Reference Module in Biomedical Sciences.(Ed. Caplan, M.), Elsevier Reference Module in Biomedical Sciences, Waltham, MA. 2014 (In Press).

Samberg ME, Tan Z, Monteiro-Riviere NA, Orndorff PE, Shirwaiker RA. Biocompatibility analysis of an electrically-activated silver-based antibacterial surface system for medical device applications. Journal of Materials Science: Materials in Medicine 24 (3):755-760, 2013.

Zhang L and Monteiro-Riviere NA. Confocal Microscopy: Implications for Nanoparticle Drug Delivery through Skin. Journal of Biomedical Optics 2013 June; 18(6):061214.

Narayan RJ, Boehm RD, Monteiro-Riviere NA. Cell and Protein Interactions with Small-Scale Diamond Materials. In The Handbook of Clinical Medicine: From Bench to Bedside (Eds. Bawa R, Audette GF, Rubinstein I), Vol.1. Chapter 15, Pan Stafford Publishing, Singapore, 2013.

Shirwaiker RA, Samberg ME, Cohen PH, Wysk RA, Monteiro-Riviere NA. Nanomaterials and synergistic low intensity direct (LIDC) stimulation technology for orthopaedic implantable medical devices. Wires Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology5(3): 191-204, 2013.

Monteiro-Riviere NA, Samberg ME, Oldenburg SJ, Riviere. Protein binding modulates the cellular uptake of silver nanoparticles into human cells: Implications for in vitro to in vivo extrapolations. Toxicology Letters 220(3):286-293, 2013

Gittard SD, Chen B, Xu H, Ovsianikov A, Chichkov BN, Monteiro-Riviere NA, Narayan RJ. The effects of geometry on skin penetration and failure of polymer microneedles. Journal of Adhesion Science and Technology27(3) 227-243, 2013.

Riviere JE, Scoglio C, Sahneh FD, Monteiro-Riviere NA. Computational approaches and metrics needed for formulating biologically realistic nanomaterials pharmacokinetic models. Computational Science & Discovery6 (2013) 014005, 2013.

Monteiro-Riviere NA, Riviere JE. Dermatotoxicity of Nanomaterials. In Handbook of Safety Assessment of Nanomaterials: From Toxicological Testing to Personalized Medicine. (Ed. Fadeel, B.), Pan Stamford Press, Chapter 14, (In Press).

Murray AR, Kisin E, Inman AO, Young SH, Muhammed M, Burks T, Uheida A, Tkach A, Waltz M, Castranova V, Fadeel B, Kagan VE, Riviere JE, Monteiro-Riviere, NA, Shvedova AA. Oxidative stress and dermal toxicity of iron oxide nanoparticles. Cell Biochemistry and Biophysics67(2): 461-476, 2013.

Monteiro-Riviere NA. Nanoparticle penetration and biological interactions with skin. In Nanotechnology in Dermatology. (Eds. A. Nasir, A Friedman and S Wang), Springer, New York, NY, Chapter 6, 51-61, 2013.

Monteiro-Riviere NA, Linder KE, Inman AO, Saathoff JG, Xia XR, Riviere JE. Lack of hydroxylated fullerene toxicity after intravenous administration to female Sprague-Dawley rats. Journal of Toxicology and Environmental Health A. 75(7): 367-373, 2012

Baynes R, Riviere J,Franz T, Monteiro-Riviere N, Lehman P, Peyrou M, Toutain P. Challenges obtaining a biowaiver for topical veterinary dosage forms. Journal of Veterinary Pharmacology and Therapeutics. 35:103-114, 2012.

Boehm RD, Chen B, Gittard SD, Chichkov BN, Monteiro-Riviere NA, Nasir A, Narayan RJ.Two-photon polymerization/micromolding of microscale barbs for medical applications. Journal of Adhesion Science and Technology.1-12, 2012

Skoog SA, Sumant A, Monteiro-Riviere NA, Narayan RJ. Ultrananocrystalline diamond-coated microporous silicon nitride membranes for medical applications. JOM: Journal of the Minerals, Metals & Materials Society 64 (4): 520-525, 2012.

Riviere JE Leavens TL, Brooks JD, Monteiro-Riviere NA. Acute vascular effects of nanoparticle infusion in isolated perfused skin. Nanomedicine: Nanotechnology, Biology and Medicine 8:428-431, 2012.

Leavens TL, Monteiro-Riviere NA, Inman AO, Brooks JB, Oldenburg, Riviere JE. In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps. Journal of Applied Toxicology 32 (11) 913-919, 2012

Boehm R, Narayan RJ, Aggarwal R, Monteiro-Riviere NA, Lacour SP.Stretchable diamond-like carbon microstructures for biomedical applications. JOM: Journal of the Minerals, Metals & Materials Society. 61 (9)53-58, 2012.

Samberg ME, Loboa EG, Oldenburg SJ, Monteiro-Riviere NA. Silver nanoparticles do not influence stem cell differentiation but cause minimal toxicity. Nanomedicine 7(8): 1197-1209, 2012.

Gittard SD, Chen B, Xu H, Ovsianikov A, Chichkov BN, Monteiro-Riviere NA, Narayan RJ. The effects of geometry on skin penetration and failure of polymer microneedles. Journal of Adhesion Science and Technology: 27(3), 227-243, 2012.

Baynes R, Riviere J,Franz T, Monteiro-Riviere N, Lehman P, Peyrou M, Toutain P. Challenges obtaining a biowaiver for topical veterinary dosage forms. J Veterinary Pharmacology and Therapeutics. 35:103-114, 2012.

Riviere JE Leavens TL, Brooks JD, Monteiro-Riviere NA. Acute vascular effects of nanoparticle infusion in isolated perfused skin. Nanomedicine: Nanotechnology, Biology and Medicine 8:428-431, 2012.

Monteiro-Riviere NA, Linder KE, Inman AO, Saathoff JG, Xia XR, Riviere JE. Lack of hydroxylated fullerene toxicity after intravenous administration to female Sprague-Dawley rats. Journal of Toxicology and Environmental Health A. 75(7): 367-3673.

Skoog SA, Sumant A, Monteiro-Riviere NA, Narayan RJ. Ultrananocrystalline diamond-coated microporous silicon nitride membranes. JOM 64 (4): 520-525, 2012.

Monteiro-Riviere NA and Larese Filon F. Effects of Engineered Nanomaterials on Skin. In Adverse Effects of Engineered Nanomaterials (Eds. B Fadeel, A. Pietroiusti, and A Shvedova), Elsevier, NY, Chapter 11, 185- 207, 2012.

Prow TW, Monteiro-Riviere NA, Inman AO. Grice JE, Chen X, Zhao X, Sanchez WH, Gierden A, Kendall MA, Zvyagin AV, Erdmann D, Riviere JE, Roberts MS. Quantum dot penetration into viable human skin. Nanotoxicology 6:173-185, 2012.

Xia XR, Monteiro-Riviere NA, Mathur S, Xuefeng S, Xiao L, Oldernburg S, Fadeel S, Riviere JE. Mapping the surface adsorption forces of nanomaterials in biological systems. ACS Nano 5: 9074-9081, 2011.

Boehm RD, Miller PR, Hayes SL, Monteiro-Riviere NA, Narayan RJ. Modification of microneedles using inkjet printing. American Institute of Physics Advances 1(2):22139, 2011

Saathoff JG, Inman AO, Xia XR, Riviere JE, Monteiro-Riviere NA. In vitro toxicity assessment of three hydroxylated fullerenes in human skin cells. Toxicology In Vitro 25:2105-2112.

Monteiro-Riviere NA, Wiench K, Landsiedel R, Schulte S, Inman AO, Riviere JE. Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: an in vitro and in vivo study. Toxicological Sciences 123 (1) 264-280, 2011.

Monteiro-Riviere NA. Commentary on transcutaneous delivery. WIREs Nanomedicine and Nanobiotechnology3: 439-440, 2011.

Zhang LW, Bäumer W, Monteiro-Riviere NA. Cellular uptake mechanisms and toxicity of quantum dots in dendritic cells. Nanomedicine 6 (5) 777-791, 2011.

Miller PR, Gittard SD, Edwards TL, Lopez DM, Xiao X, Wheeler DR, Monteiro-Riviere NA, Brozik SM, Polsky R, Narayan RJ. Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing. Biomicrofluidics 5:13415, 2011.

Hyde GK, Stewart SM, Scarel G, Parsons GN, Shih CC, Shih CM, Lin SJ, SU YY, Monteiro-Riviere NA, Narayan RJ. Atomic layer deposition of titanium dioxide on cellulose acetate for enhanced hemostasis. Biotechnology Journal 6: 213-123, 2011.

Gittard SD, Miller PR, Boehm RD, Ovianikov A, Chichkov BN, Heisner J, Gordon J, Monteiro-Riviere NA, Narayan RJ. Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles. Faraday Discussions 149: 171-185, 2011.

Samberg ME, Orndorff PE, Monteiro-Riviere NA. Antibacterial efficacy of silver nanoparticles of different sizes, surface conditions and synthesis methods. Nanotoxicology 5:244-253, 2011.

Riviere JE, Inman AO, Monteiro-Riviere NA. Absorption, Penetration and Cutaneous Toxicity of Jet Fuels and Hydrocarbons Components. In Witten ML, Zeiger E, Ritchie GD (eds.) Jet Fuel Toxicology, CRC Press, Boca Raton, Fl, Chapter 7, 119-134, 2010.

Xia XR, Monteiro-Riviere NA, Riviere JE. An index for characterization of nanomaterials in biological systems. Nature Nanotechnology 5: 671-675, 2010.

Basak SC, Gute BD, Monteiro-Riviere NA, Witzmann FA. Characterization of Toxicoproteomics Maps for Chemical Mixtures using Information Theoretic Approach. In Principles and Practice of Mixtures Toxicity. (Mumtaz MM, ed). Wiley-VCH Weinheim, Chapter 8, pp.215-234, 2010.

Doraiswany A, Ovsianikov A, Gittard SD, Monteiro-Riviere NA, Crombez R, Montalvo E, Shen W, Cichkov BN, Narayan RJ. Fabrication of microneedles using two-photon polymerization for transdermal delivery of nanomaterials. J Nanoscience and Nanotechnology 10:6305-6312, 2010.

Narayan RJ, Adiga SP, Pellin MJ, Curtiss LA, Stafslien S, Chisholm B, Monteiro-Riviere NA, Brigmon RL, Elam JW. Atomic layer deposition of nanoporous biomaterials. Materials Today 13:60-64, 2010.

Gittard SD, Ovsianikov A, Akar H, Chichkov BN, Monteiro-Riviere NA, Stafslien S, Chilsholm B, Shih CC, Shih CM, LinSJ, SuYY, Narayan RJ. Two-photon polymerization-micromolding of polyethylene glycol-gentamicin sulfate microneedles. Advanced Engineering Biomaterials 12 (4), B77-B82, 2010.

Riviere JE, Monteiro-Riviere NA. Toxicokinetics: Dermal Exposure and Absorption of Chemicals and Nanomaterials. In Comprehensive Toxicology, 2nd Ed. (McQueen C, ed). Elsevier, NY, Vol. 1. Chapter 1.05: 111-122, 2010.

Xia XR, Monteiro-Riviere NA, Riviere JE. Intrinsic biological property of colloidal fullerene nanoparticle (nC60): Lack of lethality after high dose exposure to human epidermal and bacterial cells. Toxicology Letters 197: 128-134, 2010.

Leavens TL, Xia XR, Lee HA, Monteiro-Riviere NA, Brooks JD, Riviere JE. Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles. Toxicology Letters 197:1-6, 2010.

Haslauer CM, Springer J, Harrysson OLA, Loboa EG, Monteiro-Riviere NA, Marcellin-Little DJ. In vitro biocompatibility of titanium alloy discs made using direct metal fabrication. Medical Engineering and Physics32:645-652, 2010.

Monteiro-Riviere NA, Oldenburg SJ, Inman AO. Interactions of aluminum nanoparticles with human epidermal keratinocytes. Journal of Applied Toxicology 30:276-285, 2010.

Narayan RJ, Adiga SP, Pellin MJ, Curtiss LA, Hryn AJ, Stafslien S, Chisholm B, Shih CC, Shih CM, Lin SJ, Su YY, Jin C, Zhang J, Monteiro-Riviere NA, Elam JW. Atomic layer deposition-based functionalization of materials for medical and environmental health applications. Philosophical Transactions of The Royal Society A Mathematical, Physical & Engineering Sciences 368:2033-2064, 2010.

Grissom RE, Abernathy CO, Monteiro-Riviere NA. Potential Arsenic Exposure Through Dermal Penetration. In Toxicology of the Skin-Target Organ Series. (Ed. NA Monteiro-Riviere). Informa Healthcare, New York, NY, Vol. 29, Chapter 23, 347-360, 2010.

Monteiro-Riviere NA and Baroli B. Nanomaterial Penetration. In Toxicology of the Skin-Target Organ Series. (Ed. NA Monteiro-Riviere). Informa Healthcare, New York, NY, Vol. 29, Chapter 22, 333-346, 2010.

Monteiro-Riviere NA. Structure and Function of Skin. In Toxicology of the Skin-Target Organ Series. (Ed. NA Monteiro-Riviere). Informa Healthcare, New York, NY, Vol. 29, Chapter 1, 1-18, 2010.

Samberg ME, Oldenburg SJ, Monteiro-Riviere NA. Evaluation of silver nanoparticle toxicity in vivo skin and in vitro keratinocytes. Environmental Health Perspectives 118, 407-413, 2010.

Zhang LW, Monteiro-Riviere NA. Lectins modulate multi-walled carbon nanotubes cellular uptake in human epidermal keratinocytes. Toxicology In Vitro 24: 546-551, 2010.

Xia XR, Monteiro-Riviere NA, Riviere JE. Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents. Toxicology and Applied Pharmacology 242: 29-37, 2010.

Gittard SD, Narayan RJ, Jic C, Ovsianikov A, Chichkov BN, Monteiro-Riviere NA, Stafslien S, Chisholm B. Pulsed laser deposition of antimicrobial silver coating on Ormocer microneedles. Biofabrication 1:041001, 2009.

Gittard SD, Ovsianikov A, Monteiro-Riviere NA, Lusk J, Morel P, Minghetti P,Lenardi C,Chichkov BN, Narayan RJ. Fabrication of microneedles using a two-photon polymerization and micromolding process. Journal of Diabetes Science and Technology 3: 304-311, 2009.

Zhang LW, Yang J, Barron AR, Monteiro-Riviere NA. Endocytic mechanisms and toxicity of a functionalized fullerene in human cells. Toxicology Letters 191: 149-157, 2009.

Adiga S, Jin C, Curtiss LA, Monteiro-Riviere NA, Narayan RJ. Nanoporous membranes for medical and biological applications. WIRES Nanomedicine and Nanobiotechnology 1:568-581, 2009.

Riviere JE, Monteiro-Riviere NA. Cutaneous Toxicology. In General and Applied Toxicology, (Eds. B. Ballentyne, T. Marrs, and T. 3rd Ed. Wiley: West Sussex, UK, Chapter 44, 1003-1015, 2009.

Monteiro-Riviere NA and Riviere JE. Interaction of nanomaterials with skin: Aspects of absorption and biodistribution. Nanotoxicology 3(3):188-193, 2009.

Thomas K, Monteiro-Riviere N, Warheit D, Savage N. Evaluating the risks associated with nanomaterials. In The Oxford Handbook of Nanoscience and Technology, Frontiers and Advances. (Eds. AV Narlikar and YY Du). Vol, III, Oxford University Press, Oxford, UK. Chapter 25, 888-906, 2009.

Boehm R, Narayan RJ, Aggarwal R, Monteiro-Riviere NA, Lacour S. Stretchable diamond-like carbon microstructures for biomedical applications. JOM 61: 46-51, 2009.

Zhang LW, Monteiro-Riviere NA. Mechanisms of quantum dot nanoparticle cellular uptake. Toxicological Sciences 110: 138-155, 2009.

Gittard SD, Narayan RJ, Lusk J, Morel P Stockmans F, Ramsey M, Laverde C, Phillips J, Monteiro-Riviere NA, Ovsianikov A, Chichkov BN. Rapid prototyping of scaphoid and lunate bones. Biotechnology Journal 4:129-134, 2009.

Sumanasinghe RD, Monteiro-Riviere NA, Loboa EG. Expression of proinflammatory cytokines by human mesenchymal stem cells under cyclic tensile strain. Journal of Cellular Physiology 219:77-83, 2009.

Lee HA, Leavens TL, Mason SE, Monteiro-Riviere NA, Riviere JE. Comparison of. quantum dot biodistribution with a blood-flow-limited physiologically based pharmacokinetic model. Nano Letters 794-799, 2009.

Monteiro-Riviere NA, Inman AO, Zhang LW. Limitations and relative utility of screening assays to asses engineered nanoparticle toxicity in a human cell line. Toxicology and Applied Pharmacology 234: 222-235, 2009.

Elder A, Lynch I, Grieger K, Chan-Remillard S, Gatti A,Gnewuch H, Kenawy E, Korenstein R, Kuhlbusch T, Linker F, Matias S, Monteiro-Riviere NA, Pinto V, Rudnitsky R, Savolainen K, Shvedova A. Human Health Risks of Engineered Nanomaterials. In Linkov I, Steevens J (eds.): Nanomaterials: Risks and Benefits. Springer, Dordrecht, Netherlands, 1-28, 2008.

Monteiro-Riviere NA, Zhang LW. Assessment of Quantum Dot Penetration into Skin in Different Species Under Different Mechanical Actions. In Linkov I, Steevens J (eds.): Nanomaterials: Risks and Benefits. Springer, Dordrecht, Netherlands, pp. 41-52, 2008.

Narayan RJ, Aggarwal R, Wei W, Jin C, Monteiro-Riviere NA, Crombez R, Shen W. Mechanical and biological properties of nanoporous carbon membranes. Biomedical Materials 3: 034107, 2008.

Monteiro-Riviere NA: Dermatotoxicology. In Molecular and Biochemical Toxicology. (Eds. RC Smart and E Hodgson). 4th ed, Wiley &Sons, NJ, Chapter 35, 851-880, 2008.

O'Neill AT, Monteiro-Riviere NA, Walker GM: Characterization of microfluidic human epidermal keratinocyte culture. Cytotechnology 56:197-207, 2008.

Karakoti AS, Monteiro-Riviere NA, Aggarwal R, Davis JP, Narayan RJ, Self WT, McGinnis J, Seal S. Nanoceria as antioxidant: synthesis and biomedical applications. Journal of Material Sciences 60: 33-37, 2008.

Zhang LW, and Monteiro-Riviere NA. Assessment of quantum dot penetration into intact, tape stripped, abraded and flexed rat skin. Skin Pharmacology and Physiology 21:166-180, 2008.

Inman AO, Monteiro-Riviere NA, Riviere JE. Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes. Journal of Applied Toxicology 28: 543-553, 2008.

Zhang LW, Yu WW, Colvin VL, Monteiro-Riviere NA: Biological Interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes. Toxicology and Applied Pharmacology 228:200-211, 2008.

Lin JY, Tournas JA, Burch JA, Selim MA, Monteiro-Riviere NA, Zielinski J: Topical isoflavones provide effective photoprotection to skin. Photodermatology, Photoimmunology and Photomedicine 24:61-66, 2008.

Karakoti AS, Monteiro-Riviere NA, Aggarwal R, Davis JP, Narayan RJ, Self WT, McGinnis J, Seal S: Nanoceria as antioxidant: synthesis and biomedical applications. Journal of Material Sciences 60: 33-37, 2008.

Rouse JG, Haslauer CM, Loboa EG, Monteiro-Riviere NA: Cyclic tensile strain increases interactions between human epidermal keratinocytes and quantum dot nanoparticles. Toxicology in Vitro: 22:491-497, 2008.

Roberts MS, Gierden A, Riviere JE, Monteiro-Riviere NA: Solvent and Vehicle Effects on the Skin. In Dermal Absorption and Toxicity Assessment. (Eds. MS Roberts and KA Walters). 2nd ed, Informa Healthcare, New York, NY, Chapter 24, 433-447, 2008.

Monteiro-Riviere NA, Baynes RE, Riviere JE: Animal Skin Morphology and Dermal Absorption. In Dermal Absorption and Toxicity Assessment. (Eds. MS Roberts and KA Walters). 2nd ed, Informa Healthcare, New York, NY, Chapter 2, 17-35, 2008.

Monteiro-Riviere NA: Anatomical Factors that Affect Barrier Function. In Dermatotoxicology. (Eds. H Zhai, KP Wilhelm, HI Maibach), 7th ed, CRC Press, New York, NY, Chapter 4, pp.39-50, 2008.

McCullen SD, Stano KL, Stevens DR, Roberts WA, Monteiro-Riviere NA, Clarke LI, Gorga RE: Development, optimization and characterization of electrospun poly (lactic) nanofibers containing multi-walled carbon nanotubes. Journal of Applied Polymer Science 105: 1668-1678, 2007.

Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE: A system coefficient approach for quantitative assessment of the solvent effects on membrane absorption from chemical mixtures. SAR QSAR Environmental Research18(5): 579-593, 2007.

Balbus JM, Maynard AD, Colvin VL, Castranova V, Daston GP, Denison RA, Dreher KL, Goering PL, Goldberg AM, Kulinowski KM, Monteiro-Riviere NA, Oberdorster G, Omenn GS, Pinkerton KE, Ramos KS, Rest KM, Sass JB, Silbergeld EK, and Wong BA: Meeting Report: Hazard Assessment for Nanoparticles-Report from an Interdisciplinary Workshop. Environmental Health Perspectives 115: 1654-1659, 2007.

Lee HA, Imran M, Monteiro-Riviere NA, Colvin VL, Yu WW, Riviere JE: Biodistribution of quantum dot nanoparticles in perfused skin: evidence of coating-dependency and periodicity in arterial extraction. Nano Letters 7:2865-2870, 2007.

Monteiro-Riviere NA, Orsiere T: Toxicological Impacts of Nanomaterials. In Environmental Nanotechnology: Applications and Impacts of Nanomaterials. (MR Wiesner and JY Bottero), McGraw-Hill New York, NY, Chapter 11, 395-444,2007.

Witzmann FA and Monteiro-Riviere NA: Effect of Carbon Nanotube Exposure on Keratinocyte Protein Expression. In Nanotoxicology: Characterization, Dosing, and Health Effects. (Eds. NA Monteiro-Riviere and CL Tran), Informa Healthcare, New York, NY, Chapter 13, 197-224, 2007.

Monteiro-Riviere NA, Inman AO, Ryman-Rasmussen JP. Dermal Effects of Nanomaterials: In Nanotoxicology: Characterization, Dosing, and Health Effects. (Eds. NA Monteiro-Riviere and CL Tran), Informa Healthcare, New York, NY, Chapter 19, 317-337, 2007.

Xia XR, Baynes RE, Monteiro-Riviere NA, Riviere JE: An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber array. Toxicology and Applied Pharmacology221: 320-328, 2007.

Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA: Variables Influencing Interactions of Untargeted Quantum Dot Nanoparticles with Skin Cells and Identification of Biochemical Modulators. Nano Letters 7(5): 1344-1348, 2007.

Zhang LW, Zeng L, Barron AR, Monteiro-Riviere NA: Biological Interactions of Functionalized Single-Wall Carbon Nanotubes in Human Epidermal Keratinocytes. International Journal of Toxicology 26:103-113, 2007.

Walker GM, Monteiro-Riviere N A, Rouse J, O'Neill AT: A linear dilution microfluidic device for cytotoxicity assays. Lab Chip 7: 226-232, 2007.

Wei W, Sethuraman A, Jin C, Monteiro-Riviere NA, Narayan RJ: Biological Properties of Carbon Nanotubes. Journal of Nanoscience and Nanotechnology 7:1-14,2007.

Rouse JG, Yang J, Ryman-Rasmussen, Barron AR, Monteiro-Riviere NA: Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin. Nano Letters 7: 155-160, 2007.

Leduc PR, Wong MS, Ferreira PM, Groff RE, Haslinger K, Koonce MP, Lee WY, Love JC, McCammon JA, Monteiro-Riviere NA, Rotello VM, Rubloff GW, Westervelt R, Yoda M: Towards an in vivo biologically inspired nanofactory. Nature Nanotechnology 2: 3-7, 2007.

Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA: Surface coatings determine cytotoxicity and irritation potential of quantum dot nanoparticles in epidermal keratinocytes. Journal of Investigative Dermatology 127: 143-153, 2007.

Wei C, Lyubchencho YL, Ghandehari H, Hanes J, Stebe KL, Mao HQ, Haynie DT, Tomalia DA, Foldvari M, Monteiro-Riviere N, Simeonova P, Nie S, Mori H, Gilbert SP, Needham D.: New technology and clinical applications of nanomedicine: Highlights of the second annual meeting of the American Academy of Nanomedicine (Part1). Nanomedicine: Nanotechnology, Biology and Medicine 2: 253-263, 2006.

Monteiro-Riviere NA, Inman AO, Barlow BM, Baynes RE: Dermatotoxicity of cutting fluid mixtures: In vitro and in vivo studies. Cutaneous and Ocular Toxicology 25: 235-247, 2006.

Rouse JG, Yang J, Barron AR, Monteiro-Riviere NA: Fullerene-based amino acid nanoparticle interactions with human epidermal keratinocytes. Toxicology in Vitro 20: 1313-1320, 2006.

Xia XR, Monteiro-Riviere NA, Riviere JE: Trace analysis of fullerenes in biological samples by simplified liquid-liquid extraction and high-performance liquid chromatography. Journal of Chromatography A 1129: 216-222, 2006.

Witzmann FA and Monteiro-Riviere, NA: Multi-walled carbon nanotube exposure alters protein expression in human keratinocytes. Nanomedicine: Nanotechnology, Biology, and Medicine 2: 158-168, 2006.

Monteiro-Riviere NA, Inman A, Hedgepeth V, Mosteller B, Piedrahita J: Dermatological effects of chronic exposure to 7,12-dimethylbenz[a]anthracene (DMBA) or N-methyl-n-nitrosoguanidine (MNNG) in swine. Cutaneous and Ocular Toxicology 25: 103-119, 2006.

Monteiro-Riviere NA: The Integument. In Dellman's Textbook of Veterinary Histology (Eds. JA Eurell, BL Frappier, 6th Edition) Blackwell Publishing, Ames, Iowa. Chapter 16, pp.320-349, 2006.

Yang J-H, Lee C-H, Monteiro-Riviere NA, Riviere JE, Tsang C-L, Chou C-C: Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal Keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release. Archives of Toxicology 80: 508-523, 2006.

Chou CC, Yang JH, Chen SD, Monteiro-Riviere NA, Li HN, Chen JJW: Expression profiling of human epidermal keratinocyte response following 1-minute JP-8 exposure. Journal of Cutaneous and Ocular Toxicology 25: 141-153, 2006.

Tournas JA, Lin FH, Burch JA, Selim MA, Monteiro-Riviere NA, Zielinski JE, Pinnell SR: Ubiquinone, idebenone and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acid. Journal of Investigative Dermatology 126: 1185-1187, 2006.

Monteiro-Riviere NA, Ryman-Rasmussen JP: Toxicology of Nanomaterials. In Biological Concepts and Techniques in Toxicology, (Ed. JE Riviere), Taylor and Francis, Chapter 12, pp. 217-233, 2006.

Ryman-Rasmussen JP, Riviere JE, Monteiro-Riviere NA: Penetration of intact skin by quantum dots with diverse physicochemical properties. Toxicological Sciences 91: 159- 165, 2006.

Monteiro-Riviere NA: Structure and Function of the Skin. In Dermal Absorption Models in Toxicology and Pharmacology, (Ed. JE Riviere), CRC Press, Taylor and Francis Group, New York, NY. Chapter 1, pp 1-19, 2006.

Monteiro-Riviere NA, Inman AO: Challenges for assessing carbon nanomaterial toxicity to the skin. Carbon 44: 1070-1078, 2006.

Van der merwe D, Brooks JD, Gehring R, Baynes RE, Monteiro-Riviere NA, Riviere JE: A physiological-based pharmacokinetic model of organophosphate dermal absorption. Toxicological Sciences , 188-204, 2006.

Lin FH, Lin JY, Gupta RD, Tournas JA, Burch JA, Selim MA, Monteiro-Riviere NA, Grichnik JM, Zielinski J, Pinnell SR: Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. Journal of Investigative Dermatology 125: 826-832, 2005.

Baynes RE, Yeatts JL, Brooks JD, Riviere JE: Pre-treatment effects of trichloroethylene on the dermal absorption of the biocide, triazine. Toxicology Letters 159: 252-260, 2005.

Monteiro-Riviere NA, Inman AO, Wang YY, Nemanich RJ: Surfactant effects on carbon nanotube interactions with human epidermal keratinocytes. Nanomedicine: Nanotechnology, Biology and Medicine 1: 293-299, 2005.

Monteiro-Riviere NA, Riviere JE: The Pig as a Model for Human Skin Research. In "Swine in Biomedical Research: Update on Animal Models". (Eds. M Swindle and GF Bouchard) Sinclair Research Center, p.17-22, 2005

Holsapple, MP, Farland WH, Landry TD, Monteiro-Riviere NA, Carter JM, Walker NJ, Thomas KV: Research Strategies for Safety Evaluation of Nanomaterials, Part II: Toxicological and safety evaluation of nanomaterials, current challenges and data needs. Toxicological Sciences 88: 12-17, 2005.

Witzmann FA, Monteiro-Riviere NA, Inman AO, Kimpel MA, Pedrick NM, Ringham HN, Riviere JE: Effect of JP-8 jet fuel exposure on protein expression in human keratinocyte cells in culture. Toxicology Letters 160: 8-21, 2005.

Oberdorster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman, K, Carter J, Karn B, Kreyling W, Lai D, Olin S, Monteiro-Riviere N, Warheit D, Yang H, and A Report from the ILSI Research Foundation/Risk Science Institute Nanomaterial Toxicity Screening Working Group: Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Particle and Fibre Toxicology 2: 8: 1-35, 2005.

Ferreira P, Groff R, Haslinger K, Koonce M, Le Duc P, Lee W, Love C, Mc Gammon A, Monteiro-Riviere N, Rotello V, Rubloff G, Westervelt R, Wong M, Yoda M. An in vivo nanofactory: the medicine of the future. National Academies on Designing Nanostructures at the Interface between Biomedical and Physical Systems. The National Academies Press, Washington, DC, pp. 53-60, 2005

Xia XR, Baynes, RE, Monteiro-Riviere NA, Riviere JE: Membrane uptake kinetics of jet fuel aromatic hydrocarbons from aqueous solutions studied by a membrane-coated fiber technique. Toxicology Mechanisms and Methods 15: 307-316, 2005.

Muhammad F, Monteiro-Riviere NA, Baynes RE, Riviere JE: Effect of in vivo jet fuel exposure on subsequent in vitro dermal absorption of individual aromatic and aliphatic hydrocarbon fuel constituents. Journal of Toxicology and Environmental Health 68:719-737, 2005.

Haskell SR, Payne M, Webb A, Riviere JE, Craigmill AL: Antidotes in food animal practice. Journal of the American Veterinary Medical Association 226:884-887, 2005.

Muhammad, F, Monteiro-Riviere NA, Riviere JE: Comparative in vivo toxicity of topical JP-8 jet fuel and its individual hydrocarbon components: Identification of tridecane and tetradecane as key constituents responsible for dermal irritation. Toxicologic Pathology 33:258-266, 2005.

Monteiro-Riviere NA, Nemanich RJ, Inman AO, Wang YY, Riviere JE: Multi-walled carbon nanotube interactions with human epidermal keratinocytes. Toxicology Letters 155:377-384, 2005.

Xia, XR, Baynes RE, Monteiro-Riviere NA, Riviere JE: Determination of the partition coefficients in a lipophilic membrane/water system by using a membrane-coated fiber technique. European Journal of Pharmaceutical Sciences 24:15-23, 2005.