Yufang Ding
Research Assistant Professor
Education
- Ph.D. Biomedical Engineering, Texas A&M University
- M.S. Cell Biology, University of Science and Technology of China
- B.S. Bioengineering, South China University of Technology
Office: 333 Coles Hall
Email
Research Interests
- Microbiota–host interactions, with a focus on how microbiota-derived small molecules regulate immune responses and host metabolism.
- Host–pathogen interactions across mammalian systems, with emphasis on mechanisms that influence viral infection, replication, and host susceptibility.
- Translational virology and vaccine development, particularly approaches that enhance rational design of attenuated and effective vaccines through mechanistic understanding of host and viral factors.
- Application of functional genomics tools, including CRISPR-based perturbation strategies, to dissect host determinants of infection and immune modulation.
- Development of genomic and systems-level technologies for viral characterization, including high-throughput sequencing and integrative analysis frameworks to support vaccine design and pathogen surveillance.
Oral supplementation of gut microbial metabolites indole-3-acetate alleviates diet-induced steatosis and inflammation in mice.
Ding Y, Yanagi K, Yang F, Callaway E, Cheng C, Hensel M, Menon R, Alaniz RC, Lee K, Jayaraman A
ELife. 2024 Feb 27:12:RP87458.
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors.
Replogle JM, Bonnar JL, Pogson AN, Liem CR, Maier NK, Ding Y, Russell BJ, Wang X, Leng K, Guna A, Norman TM, Pak RA, Ramos DM, Ward ME, Gilbert LA, Kampmann M, Weissman JS, Jost M Elife. 2022 Dec 28;11:e81856.
Modeling inter-kingdom regulation of inflammatory signaling in human intestinal epithelial cells.
Maiti S, Grivas G, Choi K, Dai W, Ding Y, Acosta DP, Hahn J, Jayaraman A
Comput Chem Eng. Sep 2;140:106954. 2020
Interactions between gut microbiota and non-alcoholic liver disease: the role of microbiota-derived metabolites.
Ding Y, Yanagi K, Cheng C, Alaniz RC, Lee K, Jayaraman A
Pharmacol Res. 2019 Mar;141:521-529.
Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages.
Krishnan S*, Ding Y*, Saedi N, Choi M, Sridharan GV, Sherr DH, Yarmush ML, Alaniz RC, Jayaraman A, Lee K
Cell Reports 23, 1099–1111, April 24, 2018.
Mathematical Modeling and Parameter Estimation of Intracellular Signaling Pathway: Application to LPS-induced NFκB Activation and TNFα Production in Macrophages.
Lee D, Ding Y, Jayaraman A, Kwon JS
Processes 2018, 6(3), 21.
Embedding synthetic microvascular networks in poly(lactic acid) substrates with rounded cross-sections for cell culture applications.
Huang JH, Kim J, Ding Y, Jayaraman A, Ugaz VM
PLoS One. 2013 Sep 2;8(9):e73188.