Dana L. Vanlandingham
Assistant Professor, Virology
PhD (2006), Liverpool School of Tropical Medicine, Liverpool UK
MS (1996), Colorado State University
BS (1993), Colorado State University
Office: 1039 BRI
My research is focused on zoonotic arboviruses which require high containment facilities. Some current projects are:
1) Assessment of Risk and Development of Countermeasures for a Japanese Encephalitis Introduction in the United States. Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic flavivirus that can cause fatal infections in animals and humans. The purpose of this project is to evaluate the potential for JEV establishment in the US.
2) Biology of Mosquito Vectors of Arbovirus Transmission Associated with Emerging Disease Threats of Livestock. The purpose of this project is to facilitate research to enhance the understanding of arbovirus maintenance, transmission and infection/disease in mosquitoes, swine, and sheep. The overall goals of this research program will be to understand how arboviruses adapt to insect and animal hosts and how this knowledge can be used to break the cycle of transmission and to develop better countermeasures to prevent the transmission of zoonotic diseases to human hosts.
3) Control of Emerging Bunyaviruses. Arboviruses in the family of Bunyaviridae utilize a wide range of arthropod vectors, e.g. mosquitoes, midges or ticks to transmit pathogens that have a high impact on human and veterinary public health. The overall goal of this project is to establish and evaluate a vaccine platform for the rapid generation of new vaccines to protect livestock against emerging bunyaviruses.
We have developed three courses (DMP690 Essential Practices for BSL-3, DMP691 Introduction to High Containment Research Topics and Techniques, and DMP846 Foundations in Biosecurity) which enabled us to successfully compete for a Department of Homeland Security (DHS) contract to develop new courses focused on High Containment Transboundary Animal Disease (TAD) research. In addition to these classes, I also team- teach DMP722 Veterinary Virology to second year DVM students. Additional courses include DMP 893 Principles of Biosafety and Biocontainment and organization of the seminars for DMP 970 Pathobiology Seminar.
Transboundary Animal Diseases Fellowship Training Program Goals
The contract with the Department of Homeland Security aims to foster the development of research scientists to safely plan and execute research on transboundary animal diseases (TAD) in BSL-3, BSL-3Ag, and BSL-4 environments. The academic and research experience we will develop through this training program will help address the critical need for a skilled workforce that will be required when the National Bio and Agro-Defense Facility (NBAF) opens in Manhattan, Kansas. We will build on our current training collaboration between the CVM, BRI, Plum Island Animal Disease Center, and a new agreement with the National Emerging Infectious Diseases Laboratory (BSL-4 training) in Boston. This agreement was initiated specifically to train next generation PhD, DVM, and post-doctoral researchers to work in high and maximum-containment environments on a variety of TADs. Fellows in the program will have the opportunity to work with any of the PIs that are currently studying TADs in the BRI.
- DMP690 Essential Practices for BSL-3
- DMP691 Introduction to High Containment Research Topics and Techniques
- DMP846 Foundations in Biosecurity
- DMP722 Veterinary Virology
I am the director for the BRI high containment insectary (ACL-3) and the ACL-1 laboratory. I am also the coordinator for the DMP Seminar Series since the fall of 2014. As the coordinator, we invite and host K-State, regional, national, and international speakers.
At the State and National levels, I assisted in the organization of the Kansas City Area Life Sciences Institute’s Animal Health Research Symposium entitled “The Growing Risk of Zoonotic & Vector-Borne Diseases” (http://www.kclifesciences.org/events/animal-health-symposium/) which was held in Kansas City in 2015. I recently was a Symposium Organizer for the XXV International Congress of Entomology (ICE 2016). The International Congress of Entomology symposium was held in September 2016 in Orlando, Florida. My symposium, “Arboviruses and One Health”, was focused on zoonotic arboviruses that impact the health and wellbeing of both animals and humans.
Additional non-directed service includes reviewing for numerous peer-reviewed journals and national and international grant proposals. I also serve on several PhD student committees and other institutional committees.
Professional Honors and Activities
- Fellow, Royal Entomological Society of London
- Fellow, Marty Vanier and Bob Krause Biosecurity Research Institute Research Fellow
- Director, ACL-1 and ACL-3 Insectaries, Biosecurity Research Institute
- Coordinator, Diagnostic Medicine and Pathobiology Weekly Seminar Series
- Organizer, 2016 International Congress of Entomology, “Arboviruses and One Health”
- Co-organizer, 2015 Kansas City Area Life Sciences Institute’s Animal Health Research Symposium, “The Growing Risk of Zoonotic and Vector-Borne Diseases”
Link to NCBI
for a complete list of published work
Nuckols J.T., Huang Y.J., Higgs S., Miller A.L., Pyles R.B., Spratt H., Horne K.M., Vanlandingham D.L. 2015. Evaluation of Simultaneous Transmission of Chikungunya Virus and Dengue Virus Type 2 in Infected Aedes aegypti and Aedes albopictus (Diptera: Culicidae). J. Med. Entomol. 52: 447-51. PMID 26334820 PMCID: PMC4581484
Vega-Rúa A., Lourenço-de-Oliveira R., Mousson L., Vazeille M., Fuchs S., Yébakima A., Gustave J., Girod R., Rousset D., Leparc-Goffart I., Vanlandingham D.L., Huang Y.J., Lounibos L.P., Nougairede A., de Lamballerie X., Failloux A. 2015. Chikungunya virus transmission potential by local Aedes mosquitoes in the Americas and Europe. PLoS Neglected Trop. Dis. 9(5): 30003780 PMID: 25993633 PMCID: PMC4439146
Lani R., Hassandarvish P., Chiam C.W., Moghaddam E., Chu J.J., Rausalu K., Merits A., Higgs S., Vanlandingham D., Abu Bakar, S., Zandi, K. 2015. Antiviral activity of silymarin against chikungunya virus. Sci. Reports. 5:11421. PMID: 26078201 PMCID: PMC4468427
Londono-Renteria, B., Troupin, A., Conway, M. J., Vesely, D., Ledizet, M., Roundy, C.M., Cloherty, E., Jameson, S., Vanlandingham, D., Higgs, S., Fikrig, E., Colpitts, T.M. 2015.
Dengue virus infection of Aedes aegypti requires a putative cysteine rich venom protein. PLOS Pathogens. 11:e1005202. PMID: 26491875 PMCID: PMC4619585
Huang, Y-J.S., Harbin, J.N., Hettenbach, S.M., Maki, E., Cohnstaedt, L.W., Barrett, A.D.T., Higgs, S., Vanlandingham, D.L. 2015. Susceptibility of a North American Culex quinquefasciatus to Japanese encephalitis virus. Vector-Borne Zoonotic Dis. 15: 709-11, PMID: 26565775
Huang, Y-J.S., Hettenbach, S.M., Higgs, S., Vanlandingham, D.L. 2015. Temperature tolerance and inactivation of chikungunya virus. Vector-Borne Zoonotic Dis. 15: 674-7. PMID: 26565772
Park, S.L., Huang, Y-J.S., Hsu, W-W., Hettenbach, S.M., Higgs, S., and Vanlandingham, D.L.2016. Virus-specific thermostability and heat inactivation profiles of alphaviruses. J. Virol. Methods. 234: 152-155. PMID: 27079828.
Vanlandingham, D.L., Higgs, S., Huang, Y-J.S. 2016. Aedes albopictus and mosquito-borne viruses in the United States. J. Med. Entomol. In Press Special Edition.
Troupin A., Londono-Renteria, B., Conway, M.J., Cloherty, E., Jameson, S., Higgs, S., Vanlandingham, D.L., Fikrig, E., Colpitts, T.M. 2016. A novel mosquito ubiquitin targets viral envelope protein for degradation and reduces virion production during dengue virus infection of mosquitoes. BBA General Subjects. Elsevier Publishing. Biochem. Biophys. Acta. 1860: 1898-1909. PMID: 27241849.
Lani, R., Hassandarvish, P., Shu, M. H., Phoon, W. H., Chu, J. J., Higgs, S., Vanlandingham, D., Abu Bakar, S., Zandi, K. 2016. Antiviral activity of selected flavonoids against Chikungunya virus. Antiviral Res. 133: 50-61. PMID: 27460167
Huang, Y. S., Ayers, V. B., Lyons, A. C., Unlu, I., Alto, B. W., Cohnstaedt, L. W., Higgs, S., Vanlandingham, D. L. 2016. Culex Species Mosquitoes and Zika Virus. Vector-Borne Zoonotic Dis. Epub ahead of print. PMID: 27556838.
Osuna, C. E., Lim, S. Y., Deleage, C., Griffin, B. D., Stein, D., Schroeder, L. T., Omage, R., Best, K., Luo, M., Hraber, P. T., Andersen-Elyard, H., Ojeda, E. F., Huang, S., Vanlandingham, D. L., Higgs, S., Perelson, A. S., Estes, J. D., Safronetz, D., Lewis, M. G., Whitney, J. B. 2016. Zika viral dynamics and shedding in rhesus and cynomolgus macaques. Nature medicine. doi: 10.1038/nm.4206. PMID: 27694931.
Dowd, K.A., Ko, S.Y., Morabito, K.M., Yang, E.S., Pelc, R.S., DeMaso, C.R., Castilho, L.R., Abbink, P., Boyd, M., Nityanandam, R., Gordon, D.N., Gallagher, J.R., Chen, X., Todd, J-P., Tsybovsky, Y., Harris, A., Huang, Y-J. S., Higgs, S., Vanlandingham, D.L., Andersen, H., Lewis, M.G., Barrera, R.D.L., Eckels, K.H., Jarman, R.G., Nason, M.C., Barouch, D.H., Roederer, M., Kong, W-P., Mascola, J-R., Pierson, T.C., Graham, B.S. 2016. Rapid development of a DNA vaccine for Zika virus. Science. 22 Sep 2016: DOI: 10.1126/science.aai9137.
Huang, Y.J.S., Hettenbach, S.M., Park, S.L., Higgs, S., Barrett, A.D.T., Hsu, W.W., Harbin, J.N., Cohnstaedt, L.W., Vanlandingham, D.L. 2016. Infectivity in mosquitoes contributes to the emergence of the genotype-I clade-b strain of Japanese encephalitis virus. PLoS Neglected Tropical Diseases. In Print.