Dana L. Vanlandingham, Ph.D., M.S., F.R.E.S.
Associate Professor, Arbovirology
PhD, Liverpool School of Tropical Medicine, Liverpool UK
MS, Colorado State University
BS, Colorado State University
Office: 1041 Pat Roberts Hall
My research is focused on zoonotic arboviruses most of which require high containment facilities. Some current projects are:
1) Assessment of Risk and Development of Countermeasures for a Japanese Encephalitis Introduction in the United States. Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic flavivirus that can cause fatal infections in animals and humans. The purpose of this project is to evaluate the potential for JEV establishment in the US.
2) Biology of Mosquito Vectors of Arbovirus Transmission Associated with Emerging Disease Threats of Livestock. The purpose of this project is to facilitate research to enhance the understanding of arbovirus maintenance, transmission, and infection/disease in mosquitoes, swine, and sheep. The overall goals of this research program will be to understand how arboviruses adapt to insect and animal hosts and how this knowledge can be used to break the cycle of transmission and to develop better countermeasures to prevent the transmission of zoonotic diseases to human hosts.
3) Control of Emerging Bunyaviruses. Arboviruses in the family of Bunyaviridae utilize a wide range of arthropod vectors, e.g. mosquitoes, midges, or ticks to transmit pathogens that have a high impact on human and veterinary public health. The overall goal of this project is to establish and evaluate a vaccine platform for the rapid generation of new vaccines to protect livestock against emerging bunyaviruses.
Currently funded projects:
1) State of Kansas - “Assessment of Risk and Development of Countermeasures for a Japanese Encephalitis Introduction in the United States” PI: D. Vanlandingham
2) US Department of Agriculture (Agricultural Research Service) “Biology of Mosquito Vectors of Arbovirus Transmission Associated with Emerging Disease Threats of Livestock” PI: D. Vanlandingham
3) US Department of Agriculture (NIFA) “US UK Collaborative Control of Emerging Bunyaviruses” PI: S. Higgs, Co-PI: D Vanlandingham
4) DHS Science and Technology (S&T) National Bio- and Agro-Defense Facility Transition Research Project - “Transboundary Animal Disease Workforce Development: Fellowship Training Program” PI: D. Vanlandingham
5) State of Kansas – NBAF transition funds to support “Transboundary Animal Disease Workforce Development: Fellowship Training Program” PI: D. Vanlandingham
6) Swine Health Information Center – Disease Matrix Research – “Detection of Japanese encephalitis virus in swine” PI: D. Vanlandingham
7) NIH R21 – “The role of African Green Monkeys in the epidemiology of Dengue and Chikungunya on St Kitts, West Indies” PI: Patrick Kelly; Co-I: D. Vanlandingham
I am very active in teaching graduate students and veterinary students. I team-teach DMP822 Veterinary Virology to second year DVM students. I am also developing new courses focused on High Containment Transboundary Animal Disease (TAD) research (DMP690, 691, 846, 893, 895, and 995). I also organize the seminars for the DMP 970 Pathobiology Seminar course.
Transboundary Animal Diseases Fellowship Training Program
Our contract with the Department of Homeland Security aims to foster the development of research scientists to safely plan and execute research on transboundary animal diseases (TAD) in BSL-3, BSL-3Ag, and BSL-4 environments. The academic and research experience we have developed through this training program will help address the critical need for a skilled workforce that will be required when the National Bio and Agro-Defense Facility (NBAF) opens in Manhattan, Kansas. This training is housed at the BRI but relies on collaborations between the CVM and the National Emerging Infectious Diseases Laboratory (BSL-4 training) in Boston. This program focuses on training the next generation M.S., PhD, DVM, and post-doctoral researchers to work in high and maximum-containment environments on a variety of TADs. A Certificate Program associated with this program will hopefully be offered though the CVM in the fall semester of 2018.
- DMP690 Essential Practices for BSL-3 (1 credit) (Fall 2014, 2016, 2017)
- DMP691 Introduction to High Containment Research Topics and Techniques (2 credits) (Fall 2014, 2016, 2017)
- DMP846 Foundations in Biosecurity (3 credits) (Fall 2016, 2017)
- DMP893 Principles of Biosafety and Biocontainment (3 credits) (Spring 2017, 2018)
- DMP822 Veterinary Virology (6 lectures) (Spring 2015 - Present)
- DMP970 Pathobiology Seminar (Fall 2014 - Present)
- DMP895 Select Agent Studies (3 credits) (Spring 2017, 2018)
- DMP895/995 Transboundary Animal Diseases (3 credits) (Summer 2017, 2018)
I am the director for the BRI high containment insectary (ACL-3) and the ACL-1 laboratory. I am also the coordinator for the DMP Seminar Series since the fall of 2014. As the coordinator, we invite and host K-State, regional, national, and international speakers.
At the State and National levels, I assisted in the organization of the Kansas City Area Life Sciences Institute’s Animal Health Research Symposium entitled “The Growing Risk of Zoonotic & Vector-Borne Diseases” (http://www.kclifesciences.org/events/animal-health-symposium/) which was held in Kansas City in 2015. I recently was a Symposium Organizer for the XXV International Congress of Entomology (ICE 2016). The International Congress of Entomology symposium was held in September 2016 in Orlando, Florida. My symposium, “Arboviruses and One Health”, was focused on zoonotic arboviruses that impact the health and wellbeing of both animals and humans.
Additional non-directed service includes reviewing for numerous peer-reviewed journals and national and international grant proposals. I also serve on several PhD student committees and other institutional committees.
Professional Honors and Activities
- Fellow, Royal Entomological Society of London
- Fellow, Marty Vanier and Bob Krause Biosecurity Research Institute Research Fellow
- Director, ACL-1 and ACL-3 Insectaries, Biosecurity Research Institute
- Coordinator, Diagnostic Medicine and Pathobiology Weekly Seminar Series
- Organizer, 2016 International Congress of Entomology, “Arboviruses and One Health”
- Co-organizer, 2015 Kansas City Area Life Sciences Institute’s Animal Health Research Symposium, “The Growing Risk of Zoonotic and Vector-Borne Diseases”
Link to NCBI
for a complete list of published work
Selected publications (12 most recent from a total of 73)
Park, S.L., Huang, Y-J.S., Hsu, W-W., Hettenbach, S.M., Higgs, S., and Vanlandingham, D.L. 2016. Virus-specific thermostability and heat inactivation profiles of alphaviruses. J. Virol. Methods. 234: 152-155. PMID: 27079828.
Vanlandingham, D.L., Higgs, S., Huang, Y-J.S. 2016. Aedes albopictus (Diptera: Culicidae) and mosquito-borne viruses in the United States. J. Med. Entomol. 53: 1024-1028. DOI: 10.1093/jme/tjw025. PMID: 27113107.
Troupin A., Londono-Renteria, B., Conway, M.J., Cloherty, E., Jameson, S., Higgs, S., Vanlandingham, D.L., Fikrig, E., Colpitts, T.M. 2016. A novel mosquito ubiquitin targets viral envelope protein for degradation and reduces virion production during dengue virus infection of mosquitoes. BBA General Subjects. Elsevier Publishing. Biochem. Biophys. Acta. 1860: 1898-1909. PMID: 27241849. PMCID: PMC4949077.
Lani, R., Hassandarvish, P., Shu, M. H., Phoon, W. H., Chu, J. J., Higgs, S., Vanlandingham, D., Abu Bakar, S., Zandi, K. 2016. Antiviral activity of selected flavonoids against Chikungunya virus. Antiviral Res. 133: 50-61. PMID: 27460167.
Huang, Y. S., Ayers, V. B., Lyons, A. C., Unlu, I., Alto, B. W., Cohnstaedt, L. W., Higgs, S., Vanlandingham, D. L. 2016. Culex Species Mosquitoes and Zika Virus. Vector-Borne Zoonotic Dis. 16(10): 673-76. DOI: 10.1089/vbz.2016.2058. PMID: 27556838.
Huang, Y.J.S., Hettenbach, S.M., Park, S.L., Higgs, S., Barrett, A.D.T., Hsu, W.W., Harbin, J.N., Cohnstaedt, L.W., Vanlandingham, D.L. 2016. Differential Infectivities among Different Japanese Encephalitis Virus Genotypes in Culex quinquefasciatus Mosquitoes. PLoS Negl. Trop. Dis. 10: e0005038. DOI: 10.1371/journal.pntd.0005038. PMID: 27706157. PMCID: PMC5051684.
Dowd, K.A., Ko, S.Y., Morabito, K.M., Yang, E.S., Pelc, R.S., DeMaso, C.R., Castilho, L.R., Abbink, P., Boyd, M., Nityanandam, R., Gordon, D.N., Gallagher, J.R., Chen, X., Todd, J-P., Tsybovsky, Y., Harris, A., Huang, Y-J. S., Higgs, S., Vanlandingham, D.L., Andersen, H., Lewis, M.G., Barrera, R.D.L., Eckels, K.H., Jarman, R.G., Nason, M.C., Barouch, D.H., Roederer, M., Kong, W-P., Mascola, J-R., Pierson, T.C., Graham, B.S. 2016. Rapid development of a DNA vaccine for Zika virus. Science. 22 Sep 2016. DOI: 10.1126/science.aai9137. PMID: 27708058. PMCID: PMC5304212.
Osuna, C. E., Lim, S. Y., Deleage, C., Griffin, B. D., Stein, D., Schroeder, L. T., Omage, R., Best, K., Luo, M., Hraber, P. T., Andersen-Elyard, H., Ojeda, E. F., Huang, S., Vanlandingham, D. L., Higgs, S., Perelson, A. S., Estes, J. D., Safronetz, D., Lewis, M. G., Whitney, J. B. 2016. Zika viral dynamics and shedding in rhesus and cynomolgus macaques. Nature medicine. DOI: 10.1038/nm.4206. PMID: 27694931. PMCID: PMC5293594.
Huang, Y.J.S., Lyons, A.C., Hsu, W.W., Park, S.L., Higgs, S., Vanlandingham, D.L. 2017. Differential outcomes of Zika virus infection in Aedes aegypti orally challenged with infectious blood meals and infectious protein meals. PLoS One. 12(8): e0182386. DOI: 10.1371/journal.pone.0182386. PMID: 28796799.
Huang, Y.-J.S., Higgs, S., Vanlandingham, D.L. 2017. Biological Control Strategies for Mosquito Vectors of Arboviruses. Insects. 8: 21. DOI: 10.3390/insects8010021. PMID: 28208639.
Pardi, N., Hogan, M.J., Pelc, R.S., Muramatsu, H., Andersen, H., Demaso, C.R., Dowd, K.A., Sutherland, L.L., Scearce, R.M., Parks, R., Wagner, W., Granados, A., Greenhouse, J., Walker, M., Willis, E., Yu, J-S., McGee, C.E., Sempowski, G.D., Mui, B.L., Tam, Y.K., Huang, Y-J., Vanlandingham, D., Holmes, V.M., Balachandran, H., Sahu, S., Lifton, M., Higgs, S., Hensley, S.E., Madden, T.D., Hope, M.J., Kariko, K., Santra, S., Graham, B.S., Lewis, M.G., Pierson, T.C., Haynes, B.F., Weissman, D. 2017 Zika virus protection by a single low dose nucleoside modified mRNA vaccination. Nature. 543(7644): 248-251 DOI: 10.1038/nature21428. PMID: 27694931. PMCID: PMC5293594.
George J., Valiant W.G., Mattapallil M.J., Walker M., Huang Y.S., Vanlandingham D.L., Misamore J., Greenhouse J., Weiss D.E., Verthelyi D., Higgs S., Andersen H., Lewis M.G., Mattapallil J.J. 2017. Prior Exposure to Zika Virus Significantly Enhances Peak Dengue-2 Viremia in Rhesus Macaques. Sci Rep. 2017 Sep 5;7(1):10498. DOI: 10.1038/s41598-017-10901-1. PMCID: PMC5585353.