DVM – Seoul National University
MS – Veterinary Pathology, Seoul National University
PhD – Veterinary Preventive Medicine, The Ohio State University
Post-Doctoral training – National Institutes of Health
Diplomate, American College of Veterinary Microbiologists (Immunology)
Main research interests
My research interests include pathogenesis of human and animal viral diseases and the development of screening assay platforms for antiviral drugs and animal models of virus infections with the aim of developing antiviral drugs. In particular, human and animal coronaviruses, such as feline infectious peritonitis and MERS, human norovirus and influenza virus are the focus of my research.
I teach feline viral diseases in the Veterinary Virology course (DMP 822) for second year veterinary students. I also teach antivirals and resistance in Pathogenic mechanism of viruses course (DMP 910) for graduate students.
A complete list of publication from PubMed
1. Antiviral drug development for feline infectious peritonitis (FIP). FIP is a fatal systemic coronavirus infection and a leading cause of death in young cats for which no effective preventive or treatment is available. Over the years, we have developed antiviral compounds for FIP and demonstrated their effectiveness in cats with experimentally-infected or naturally-occurring FIP.
Pedersen, N.C., Kim, Y., Liu, H., Kankanamalage, A.C.G., Eckstrand, C., Groutas, W.C., Bannasch, M., Meadows, J.M and Chang, K.O. (2017). Efficacy of a 3c-like Protease Inhibitor in Treating Various Forms of Acquired Feline Infectious Peritonitis. Journal of Feline Medicine and Surgery. https://doi.org/10.1177/1098612X17729626.
Kim, Y., Liu, H., Galasiti Kankanamalage, A.C., Weerasekara, S., Hua, D.H., Groutas, W.C., Chang, K.O., and Pedersen, N.C. (2016). Reversal of the progression of fatal coronavirus infection in cats by a broad-spectrum coronavirus protease inhibitor. PLOS Pathogen, 12(3), e1005531. doi:10.1371/journal.ppat.1005531.
Kim, Y., Shivanna, V., Narayanan, S., Prior, A.M., Weerasekara, S., Hua, D.H., Galasiti Kankanamalage, A.C., Groutas, W.C., and Chang, K.O. (2015). Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses. J Virol, 89(9), 4942-4950. PMCID: PMC4403489.
Kim, Y., Mandadapu, S.R., Groutas, W.C., and Chang K.O. (2013). Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease. Antiviral Res, 97(2), 161-168.
2. Antiviral drug development for human norovirus, coronavirus and influenza virus. Coronavirus, picornavirus and caliciviruses have highly conserved viral proteases that may serve as targets for developing broad-spectrum antiviral drugs. We have been focusing on developing protease inhibitors for these viral diseases and elucidating resistance mechanisms associated with antiviral drugs.
Damalanka, V., Kim, Y., Galasiti Kankanamalage, A., Lushington, G., Mehzabeen, N., Battaile, K., Lovell, S., Chang, K.O., and Groutas, W. (2017). Design, Synthesis, and Evaluation of a Novel Series of Macrocyclic Inhibitors of Norovirus 3CL Protease. Eur J Med Chem, 127, 41-61.
Damalanka, V., Kim, Y., Alliston, K., Weerawarna, P., Galasiti Kankanamalage, A., Lushington, G., Mehzabeen, N., Battaile, K., Lovell, S., Chang, K.O., and Groutas, W. (2016). Oxadiazole-based cell permeable macrocyclic transition state inhibitors of norovirus 3CL protease. Eur J Med Chem, 59(5), 1899-1913.
Kim, Y., Galasiti Kankanamalage, A.C., Damalanka, V. C., Weerawarna, P.M., Groutas, W.C. and Chang, K.O. (2016). Potent inhibition of enterovirus D68 and human rhinoviruses by dipeptidyl aldehydes and α-ketoamides. Antiviral Research, 125. 84-91.
Kim, Y., Lovell, S., Tiew K.C., Mandadapu, S.R., Alliston, K.R., Battaile, K.P., Groutas, W.C., and Chang K.O. (2012). Broad-spectrum antivirals against 3C or 3C-Like proteases of picornaviruses, noroviruses, and coronaviruses. J Virol, 86(21), 11754-11762.
3. Virus entry and cellular factors important for virus replication. Understanding viral entry and replication steps offers important insights into viral pathogenesis and may provide potential targets for antiviral drug development. We have been investigating cellular pathways or factors that are important for the replication of viruses in in vitro and/or in vivo systems.
Kim, Y., Oh, C., Shivanna, V., Hesse, R., and Chang, K.O. (2017). Trypsin-Independent Porcine Epidemic Diarrhea Virus US Strains with Altered Virus Entry Mechanism. BMC Veterinary Research, 13(1), 356.
Shivanna, V., Kim, Y. and Chang, K.O. (2015). Ceramide formation mediated by acid sphingomyelinase facilitates endosomal escape of caliciviruses. Virology, 483, 218-228.
Shivanna, V., Kim, Y., and Chang, K.O. (2014). Endosomal acidification and cathepsin L activity is required for calicivirus replication. Virology, (464-465), 287-295.
Kim, Y., and Chang, K.O. (2011). Inhibitory effects of bile acids and synthetic farnesoid X receptor agonists on rotavirus replication. J Virol, 85(23), 12570-12577.
Kim, Y., Narayanan, S., and Chang, K.O. (2010). Inhibition of influenza virus replication by plant-derived isoquercetin. Antiviral Res., 88(2), 227-235.