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College of Veterinary Medicine

Jürgen A. Richt

 Regents Distinguished Professor & KBA Eminent Scholar

Director
Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD),  www.ceezad.org 

Director
NIH COBRE Center on Emerging and Zoonotic Infectious Diseases (CEZID) www.k-state.edu/cezid

DVM (1985), University of München, Germany
PhD Virology (1988), University of Giessen, Germany

Kansas State University, Manhattan, KS
Regents Distinguished Professor, Diagnostic Medicine Pathobiology
Office: Mosier Hall K-224-B
Phone: (785) 532 -2793 
Fax: (785) 532 3373
Email: jricht@vet.k-state.edu

Research

During my 25+ year scientific career, I have studied pathogen-host interactions in various infectious disease models including Avian and Swine Influenza viruses (AIV, SIV), African Swine Fever virus (ASFV), Rift Valley Fever virus (RVFV), Vesicular Stomatitis virus (VSV), Schmallenberg virus (SBV), animal prion diseases and Borna Disease Virus (BDV). On these topics, I have published more than 250 peer-reviewed scientific manuscripts. I am an editor for Virus Genes and serve on editorial boards for other scientific journals. Currently, I am the Director of the Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD) and the NIH COBRE Center on Emerging and Zoonotic Infectious Diseases (CEZID). I hold the prestigious Regents Distinguished and University Distinguished Professor appointments at Kansas State University.

The overall goal of my research is to investigate zoonotic, emerging and transboundary diseases of livestock focusing mainly on viral diseases. My lab established the first reverse genetics system for SIVs, made seminal contributions to the development of a modified live SIV vaccine (sold in the U.S. as Ingelvac Provenza™), and contributed to understanding the virulence of the reconstructed 1918 "Spanish Flu" virus in livestock. We also worked on the isolation and characterization of novel swine influenza virus subtypes including the H2N3 reassortant virus and the 2009 pandemic H1N1 virus, and studied their zoonotic potential using nonhuman primate models. We identified an atypical BSE case with a causative mutation ("genetic BSE"), used gene-editing approaches to develop the first prion protein knock-out cattle that are resistant to prion infection, and provided valuable information on host range of animal prions essential for risk analysis.

Our RVFV work led to the development of novel domestic and wild ruminant models for RVF and a safe, efficacious, and DIVA-compatible subunit RVF vaccine. For ASFV, we are developing subunit and modified live virus vaccine candidates as well as point-of-need diagnostic tools (PenCheckTM) to protect swine from this devastating disease. Our recent work focuses on the establishment of preclinical animal models for SARS-CoV-2 in pigs, cats, hamsters and ferrets in order to evaluate the efficacy of COVID-19 vaccines and therapeutics. As founding Director of the DHS CEEZAD and the NIH CEZID Centers, our laboratory is supporting NIH, DHS and USDA in protecting U.S. public health and agricultural systems from devastating animal and zoonotic diseases

Selected Publications

Complete List of Published work in MyBibliography: http://www.ncbi.nlm.nih.gov/sites/myncbi/1zK1knbx3FQkC/bibliography/47960468/public/?sort=date&direction=ascending

  1. Jingjiao Ma, Jinhwa Lee, Haixia Liu, Ignacio Mena, A. Sally Davis, Sun Young Sunwoo, Yuekun Lang, Michael Duff, Igor Morozov, Yuhao Li, Jianmei Yang, Adolfo García-Sastre, Juergen A. Richt, Wenjun Ma. Newcastle disease virus-based H5 influenza vaccine protects chickens from lethal challenge with a highly pathogenic H5N2 avian influenza virus. NPJ Vaccines, in press.
  2. Yolanda Revilla, Daniel Pérez-Núñez and Juergen A. Richt. ASFV biology and vaccine approaches. Adv. Virus Res., in press.
  3. Haley NJ, Rielinger R, Davenport KA, O'Rourke K, Mitchell G, Richt JA. Estimating chronic wasting disease susceptibility in cervids using real-time quaking-induced conversion. J Gen Virol. 2017 Nov;98(11):2882-2892.
  4. Faburay B, LaBeaud AD, McVey DS, Wilson WC, Richt JA. Current Status of Rift Valley Fever Vaccine Development. Vaccines (Basel). 2017 Sep 19;5(3).
  5. Sánchez EG, Riera E, Nogal M, Gallardo C, Fernández P, Bello-Morales R, López-Guerrero JA, Chitko-McKown CG, Richt JA, Revilla Y. Phenotyping and susceptibility of established porcine cells lines to African Swine Fever Virus infection and viral production. Sci Rep. 2017 Sep 4;7(1):10369.
  6. Yilmaz H, Karakullukcu A, Turan N, Cizmecigil UY, Yilmaz A, Ozkul AA, Aydin O, Gunduz A, Mete M, Zeyrek FY, Kirazoglu TT, Richt JA, Kocazeybek B. Genotypes of hepatitis a virus in Turkey: first report and clinical profile of children infected with sub-genotypes IA and IIIA. BMC Infect Dis. 2017 Aug 11;17(1):561.
  7. Haley NJ, Richt JA. Evolution of Diagnostic Tests for Chronic Wasting Disease, a Naturally Occurring Prion Disease of Cervids. Pathogens. 2017 Aug 5;6(3).
  8. Danqi B, Li Z, Liu Q, Richt JA. H7N9 avian influenza A virus in China: a short report on its circulation, drug resistant mutants and novel antiviral drugs. Expert Rev Anti Infect Ther. 2017 Aug;15(8):723-727.
  9. Mancera Gracia JC, Van den Hoecke S, Richt JA, Ma W, Saelens X, Van Reeth K. A reassortant H9N2 influenza virus containing 2009 pandemic H1N1 internal-protein genes acquired enhanced pig-to-pig transmission after serial passages in swine.Sci Rep. 2017 May 2;7(1):1323.
  10. Lee J, Yu H, Li Y, Ma J, Lang Y, Duff M, Henningson J, Liu Q, Li Y, Nagy A, Bawa B, Li Z, Tong G, Richt JA, Ma W. Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses.Virology. 2017 Apr; 504:25-35.
  11. Yilmaz H, Tekelioglu BK, Gurel A, Bamac OE, Ozturk GY, Cizmecigil UY, Altan E, Aydin O, Yilmaz A, Berriatua E, Helps CR, Richt JA, Turan N. Frequency, clinicopathological features and phylogenetic analysis of feline morbillivirus in cats in Istanbul, Turkey. J Feline Med Surg. 2017 Dec;19(12):1206-1214.
  12. Yang J, Lee J, Ma J, Lang Y, Nietfeld J, Li Y, Duff M, Li Y, Yang Y, Liu H, Zhou B, Wentworth DE, Richt JA, Li Z, Ma W. Pathogenicity of modified bat influenza virus with different M genes and its reassortment potential with swine influenza A virus. J Gen Virol. 2017 Apr;98(4):577-584.
  13. Bian J, Khaychuk V, Angers RC, Fernández-Borges N, Vidal E, Meyerett-Reid C, Kim S, Calvi CL, Bartz JC, Hoover EA, Agrimi U, Richt JA, Castilla J, Telling GC. Prion replication without host adaptation during interspecies transmissions. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1141-1146.
  14. van Doremalen N, Hijazeen ZS, Holloway P, Al Omari B, McDowell C, Adney D, Talafha HA, Guitian J, Steel J, Amarin N, Tibbo M, Abu-Basha E, Al-Majali AM, Munster VJ, Richt JA. High Prevalence of Middle East Respiratory Coronavirus in Young Dromedary Camels in Jordan. Vector Borne Zoonotic Dis. 2017 Feb;17(2):155-159.
  15. Faburay B, Wilson WC, Gaudreault NN, Davis AS, Shivanna V, Bawa B, Sunwoo SY, Ma W, Drolet BS, Morozov I, McVey DS, Richt JA. 2016. A Recombinant Rift Valley Fever Virus Glycoprotein Subunit Vaccine Confers Full Protection against Rift Valley Fever Challenge in Sheep. Sci Rep. 6: 27719. doi: 10.1038/srep27719.  PMID:27296136
  16. Wilson WC, Davis AS, Gaudreault NN, Faburay B, Trujillo JD, Shivanna V, Sunwoo SY, Balogh A, Endalew A, Ma W, Drolet BS, Ruder MG, Morozov I, McVey DS, Richt JA. 2016. Experimental Infection of Calves by Two Genetically-Distinct Strains of Rift Valley Fever Virus. Viruses. 8(5). pii: E145. doi: 10.3390/v8050145. PMID: 27223298.
  17. Nagy A, Lee J, Mena I, Henningson J, Li Y, Ma J, Duff M, Li Y, Lang Y, Yang J, Abdallah F, Richt J, Ali A, García-Sastre A, Ma W. 2016. Recombinant Newcastle disease virus expressing H9 HA protects chickens against heterologous avian influenza H9N2 virus challenge. Vaccine 34:2537-45.
  18. Rao QRicht JAHsieh YP. 2016.  Immunoassay for the Detection of Animal Central Nervous Tissue in Processed Meat and Feed Products. J. Agric. Food. Chem. 64: 3661-68.
  19. Haley NSiepker CGreenlee JRicht JA. 2016. Limited amplification of chronic wasting disease prions in the peripheral tissues of intracerebrally inoculated cattle. J. Gen. Virol. doi: 10.1099/jgv.0.000438.[Epub ahead of print]. PMID:27031704
  20. Balzli CLager K, Vincent A, Gauger PBrockmeier SMiller LRicht JAMa WSuarez DSwayne DE. 2016. Susceptibility of swine to H5 and H7 low pathogenic avian influenza viruses. Influenza Other Respir. Viruses 10:346-52.
  21. Moore SJSmith JDGreenlee MHNicholson EMRicht JAGreenlee JJ. 2016. Comparison of Two US Sheep Scrapie Isolates Supports Identification as Separate Strains. Vet. Pathol. pii: 0300985816629712. [Epub ahead of print]. PMID: 26936223
  22. Artiaga BLYang GHackmann TJLiu QRicht JASalek-Ardakani SCastleman WLLednicky JADriver JP. 2016. α-Galactosylceramide protects swine against influenza infection when administered as a vaccine adjuvant. Sci. Rep. 6:23593.
  23. Haley NJSiepker CHoon-Hanks LLMitchell GWalter WDManca MMonello RJPowers JGWild MAHoover EACaughey BRicht JA. 2016. Seeded Amplification of Chronic Wasting Disease Prions in Nasal Brushings and Recto-anal Mucosa-Associated Lymphoid Tissues from Elk by Real-Time Quaking-Induced Conversion. J. Clin. Microbiol. 54:1117-1126.
  24. Haley NJSiepker CWalter WDThomsen BVGreenlee JJLehmkuhl ADRicht JA. 2016. Antemortem Detection of Chronic Wasting Disease Prions in Nasal Brush Collections and Rectal Biopsy Specimens from White-Tailed Deer by Real-Time Quaking-Induced Conversion. J. Clin. Microbiol. 54: 1108-1116.
  25. Faburay, B, Gaudreault, NN, Liu, Q., Davis, AS, Shivanna, V, Sunwoo, SY, Lang, Y, Morozov, I, Ruder, M, Drolet, B, McVey, DS, Ma, W, Wilson, W, Richt, JA. 2016. Development of a sheep challenge model for Rift Valley fever. Virology 489:128-140.