College of Veterinary Medicine

Schedule

Objective

To explore how quantitative in silico models can improve pharmacokinetic and pharmacodynamic data analyses, leading to increased efficiency and higher success rates in veterinary drug research and development.

Specific Aims

  • To introduce the participants to the history, philosophy and applications of computational methods in medicine.

  • To introduce the participants to quantitative methods in the assessment of kinetic/dynamic data (Chapters 3 and 4 in textbook by Gabrielsson and Hjorth, 1st edition 2012)

  • To review basic concepts on instantaneous and time-delays observed in pharmacological response

  • To integrate concentration-response relationships with factors causing time-delays and how this affects the response-time course

  • To learn about exploratory (graphical) data analysis

  • To learn about pattern recognition in pharmacokinetic responses

  • To learn about pattern recognition of pharmacodynamic responses

  • To demonstrate practical applications of PKPD modeling for veterinary drugs

Schedule

Monday
Time Title Lecturer
8:30 -
8:45 a.m.		 Welcome Dr. Ronette Gehring
8:45 -
9:45 a.m.		 An Introduction to the histroy, philosophy and applications of computational methods in medicine Dr. Jim Riviere
9:45 -
10:00 a.m.		 Coffee Break
10:00 -
11:00 a.m.		 Martha's Table or Occam's razor? - An overview of different approaches to data analysis and quantitative models, and how we can choose between them. Dr. Ronette Gehring
11:00 -
12:00 p.m.		 Pharmacokinetics from a pharmacodynamics point of view Dr. Ronette Gehring
12:00 -
1:00 p.m.		 Lunch
1:00 -
2:00 p.m.

Pharmacodynamics I – Rapid equilibria

  • Time course of response, Pattern recognition
  • The PD gallery
  • Design Issues and Case Studies
 Dr. Johan Gabrielsson
2:00 -
2:30 p.m.		 Coffee Break
2:30 -
3:30 p.m.

Pharmacodynamics II – Link models

  • What is causing a distributional delay?
  • Recap of basic rate processes
  • Pattern recognition
  • Discussion about terminology and concepts
 Dr. Johan Gabrielsson
3:30 -
4:30 p.m.

Hands on Exercises and Examples

Tuesday
Time Title Lecturer
8:30 -
8:45 a.m.		 Welcome and Review of Previous Day Dr. Ronette Gehring
8:45 -
9:45 a.m.

The current veterinary drug approval process and how quantitative models can help

  • Intra/interindividual variability
  • Interspecies scaling
  • Study design
  • Data extrapolation
 Dr. Jim Riviere
9:45 -
10:00 a.m.		 Coffee Break
10:00 -
11:00 a.m.

Pharmacodynamics III - Turnover

  • Turnover rate, Fractional turnover rate, Turnover time
  • Rate equations
  • Drug mechanism functions
  • Equilibrium concentration-response relationships
  • Design Issues and Case Studies
 Dr. Johan Gabrielsson
11:00 -
12:00 p.m.

Understand the response-time course

  • Understand C-R and time delays
 Dr. Johan Gabrielsson
12:00 -
1:00 p.m.		 Lunch
1:00 -
2:00 p.m.

Pattern recognition exercise II

  • Baseline, onset, time-delay, peak-shift, saturation
  • Discrimination between distributional-, on/off- and turnover-driven delays?
  • Discussion about terminology and new concepts
 Dr. Johan Gabrielsson
2:00 -
2:30 p.m.		 Coffee Break
2;30 -
3:30 p.m.		 Hands-on Exercises and Examples
3:30 -
4:30 p.m.

Time for discussion and debate with participants

  • How can these approaches be applied in practice
  • Challenges and obstacles to applying these methods
  • Veterinary specific challenges
  • Veterinary specific opportunities