David C. Poole

David PooleUniversity Distinguished Professor of Kinesiology and Physiology

PhD, UCLA, 1986
DSc, Liverpool John Moores University, 2000
Curriculum Vitae

Coles Hall 131
Phone: 785-532-4529
Email: poole@vet.k-state.edu

Research Interests

David Poole is recognized internationally for his contributions to the fields of pulmonary gas exchange and skeletal muscle structure/function relationships. He has published over 350 peer reviewed papers and reviews in journals such as Circulation Research, Journal of Clinical Investigation, American Journal of Physiology, Journal of Physiology, Journal of Applied Physiology, FUNCTION and the British Medical Journal. Dr. Poole regularly presents his work before national and international scientific audiences. As Principal Investigator he has received over $6 million in funding with $31 million as Co-Investigator to examine the limitations to oxygen transport from lungs to mitochondria. This work has provided unique insights into healthy function and the pathophysiology associated with major disease conditions such as emphysema, diabetes, chronic heart failure and potentially cancer.

Dr. Poole's laboratory is currently funded by grants from the National Institutes of Health and the K-State Johnson Cancer Research Center and encourages a vibrant scientific atmosphere which stimulates productive interactions among faculty and students. Foremost among his collaborators at K-State, Dr. Poole wishes to acknowledge the significant contributions of Dr. Thomas J. Barstow, Dr. Timothy I. Musch, Dr. Howard H. Erickson, Dr. M. Roger Fedde, Dr. Casey A. Kindig and Dr. Brad J. Behnke.

Dr. Poole holds the Coffman Chair for Distinguished University Undergraduate Teaching Scholars. He is a Fellow of the American College of Sports Medicine (ACSM) and the American Physiological Society (APS). Dr. Poole won the ACSM’s Citation Award in 2019 and his distinguished lectureships include: E.F. Adolph (APS 2018), J.B. Wolffe (ACSM 2021), Historical Lecture (APS 2022). His current h-index is 84 with over 26,000 citations.

In collaboration with Professor Andrew M. Jones of Manchester Metropolitan University in England, Dr. Poole has published a textbook entitled: "Oxygen Uptake Kinetics in Sport, Exercise and Medicine": Routledge, London and New York, 2005, ISBN #-0-415-30560-8 (hardback) and 0-415-30561-6 (softback).

See: https://en.wikipedia.org/wiki/David_C._Poole


Selected Publications

Colburn, T.D., R.E. Weber, K.S. Hageman, J.T. Caldwell, K.M. Schulze, C.J. Ade, B.J. Behnke, D.C. Poole, and T.I. Musch. Vascular ATP-sensitive K+ channels support maximal aerobic capacity and critical speed via convective and diffusive O2 transport. J. Physiol. 598(21):4843-4858, 2020.

Ikegami, R., H. Eshima, T. Nakajima, S. Toyoda, D.C.Poole, and Y. Kano. Type I diabetes suppresses intracellular calcium ion increase normally evoked by heat stress in rat skeletal muscle. Am. J. Physiol. Reg. 320: R384-392, 2021.

Butenas, A., T.D. Colburn, D. Baumfalk, C.A., Ade, K.S. Hageman, S.W. Copp, D.C. Poole and T.I. Musch. Angiotensin converting enzyme inhibition improves cerebrovascular control during exercise in rats with heart failure. Respir Physiol Neurobiol. 286:103613, 2021.

Hirai, D.M., A. Tabuchi, J.C. Craig, T.D. Colburn, T.I. Musch, and D.C. Poole. Regulation of capillary hemodynamics by KATP channels in resting skeletal muscle. Physiol. Rep. 9(8): e14803, 2021.

Zamani, P., E.A. Proto, N. Wilson, D.C. Poole, et al. Multimodality assessment of the skeletal muscle in HFpEF reveals anatomic differences in the machinery of energy metabolism and exercise. Euro Soc. Cardiol.: Heart Failure, doi: 10.1002/ehf2.13329, 2021.

Colburn, T.D., R.E. Weber, K.M. Schulze, K.S. Hageman, A.G. Horn, B.J. Behnke, D.C. Poole, and T.I. Musch. Sexual dimorphism in vascular ATP-sensitive K+ channel function supporting interstitial PO2 via convective and/or diffusive O2 transport. J. Physiol. 599: 3279-3293, 2021.

Shimotsu, R., K. Hotta, R. Ikegami, T. Asamura, A. Tabuchi, K. Masamoto, K. Yagishita, D.C. Poole, and Y. Kano. Vascular permeability of skeletal muscle microvessels in rat arterial ligation model: in vivo analysis using two-photon laser scanning microscopy. Am. J. Physiol. Reg. 320: R972-R983, 2021.

Smith, J.R., D.M. Hirai, S.W. Copp, S.K. Ferguson, C.T. Holdsworth, K.S. Hageman,D.C. Poole, and T.I. Musch. Exercise training decreases intercostal and transversus abdominis muscle blood flows in heart failure rats during submaximal exercise. Respir. Physiol. Neurobiol. 292:103710, 2021.

Ade, C.A., Turpin V-R.G., Parr, S.K., Hammond, S.T., White, Z., Weber, R.E., Schulze, K.M., Colburn, T.D., Poole, D.C. Does wearing a facemask decrease arterial blood oxygenation and impair exercise tolerance? Respir. Physiol. Neurobiol. Dec; 294:103765, 2021.

Horn, AG., O.N. Kunkel, D.R. Baumfalk, M.E. Simon, K.M. Schulze, W-W. Hsu, J. Muller-Delp, D.C. Poole, and B.J. Behnke. Prolonged mechanical ventilation increases diaphragm arteriole circumferential stretch without changes in stress/stretch: Implications for the pathogenesis of ventilator-induced diaphragm dysfunction. Microcirculation, e12727, 2021.

Goulding, R., S. Marwood, T-H. Lei, D. Okushima, D.C. Poole, T.J. Barstow, N. Kondo, and S. Koga. Dissociation between exercise intensity thresholds: mechanistic insights from supine exercise. Am. J. Physiol. Reg. 321(5):R712-R722, 2021.

Schulze, K.M., R.E. Weber, T.D. Colburn, A.G. Horn, C.J. Ade, W-W. Hsu, D.C. Poole, and T.I. Musch. The effects of pulmonary hypertension on skeletal muscle oxygen pressures in contracting rat spinotrapezius muscle. Exp. Physiol. 106: 2070-2082, 2021.

Tabuchi, A., Y. Tanaka, R. Takagi, H. Shirakawa, T. Shibaguchi, T. Sugiura, D.C. Poole, Y. Kano. Ryanodine receptors mediate high intracellular Ca2+ and some myocyte damage following eccentric contractions in rat fast twitch skeletal muscle. Am. J. Physiol. Reg. 322(1):R14-R27, 2022.

Horn, A.G., K.M. Schulze, R.E. Weber, T.J. Barstow, T.I. Musch, D.C. Poole, B.J. Behnke. Post-occlusive reactive hyperemia and skeletal muscle capillary hemodynamics. Microvasc. Res. 140:104283, 2022.

Weber, R.E., K.M. Schulze, T.D. Colburn, A.G. Horn, K. Sue Hageman, C.J. Ade, S.E. Hall, P. Sandner, T.I. Musch, and D.C. Poole. Capillary hemodynamics and contracting skeletal muscle oxygen pressures in rats with heart failure: Impact of soluble guanylyl cyclase activator. Nitric Oxide, 119:1-8, 2022.

Schulze, K.M., R.E. Weber, A.G. Horn, T.D. Colburn, C.J. Ade, D.C. Poole, and T.I. Musch. Effects of pulmonary hypertension on microcirculatory hemodynamics in rat skeletal muscle. Microvasc. Res. 141: 104334, 2022.

Horn, A.G., O.N. Kunkel, K.M. Schulze, D.R. Baumfalk, R.E. Weber, D.C. Poole, B.J. Behnke. Supplemental oxygen administration during mechanical ventilation reduces diaphragm blood flow and oxygen delivery. J. Appl. Physiol. 132:1190-1200, 2022.

Rose, G.A., R.G. Davies, I.R. Appadurai, I.M. Williams, M. Bashir, R.M. Berg, D.C. Poole, and D.M. Bailey. ‘Fit for surgery’: the relationship between cardiorespiratory fitness and postoperative outcomes. Exp. Physiol., 107: 787-799, 2022.

Gaesser, G.A., Poole, D.C., and Angadi, A.S. Quantifying the benefits of inefficient walking: Monty Python inspired laboratory based experimental study. British Medical Journal, 379:e072833, 2022. Altmetrics score >1390 – Top 0.03%, >99th percentile.

Gaesser, G.A., Poole, D.C., and Angadi, A.S. Fast Facts: Measuring human energy expenditure: public health application to counter inactivity. British Medical Journal, 379:o2937, 2022.

Poole, D.C., Copp, S.W., and Musch, T.I. A straightforward graphical/statistical approach to help substantiate cheating on multiple choice

examinations. Adv. Physiol. Edu., 47: 37-41, 2023.

Butenas, A.L.E., Copp, S.W., Hageman, K. Sue, Poole, D.C., and Musch, T.I. Effects of co-morbid Type II Diabetes Mellitus and Heart

Failure on Rat Hindlimb and Respiratory Muscle Blood Flow during Treadmill Exercise. J. Appl. Physiol. 134(4):846-857, 2023.

Rose, G.A., Davies, R.G., Torkington, J., Berg, R.M.G., Appadurai, I.R., Poole, D.C., and Bailey, D.M. Assessing cardiorespiratory fitness relative to sex improves surgical risk stratification. Europ J Clin Invest. Mar 13:e13981, 2023.