Butch KuKanich
Professor of Pharmacology
DVM, VA-MD Regional College of Veterinary Medicine, Virginia Tech, 1997
PhD, Comparative Biomedical Sciences, NC State University, 2005
Diplomate, ACVCP
Phone: 785-532-4554
Email: kukanich@ksu.edu
Google Scholar page: Butch KuKanich - Google Scholar
Research Interests
The focus of the KuKanich Clinical Pharmacology Research Program at Kansas State University is the evaluation, design, and optimization of drug dosages through the use of clinical trials, pharmacokinetic, pharmacodynamic, and pharmacokinetic-pharmacodynamic studies. The evaluation of analgesics and analgesic adjuncts in companion animals is an area of emphasis for the research program. Collaborative studies in all areas of pharmacology are supported by the laboratory through analytical methodology, study design, pharmacokinetic, and pharmacokinetic-pharmacodynamic modeling.
Selected Publications
Bieberly, ZD, KuKanich B, KuKanich, KS, Berke, KA, Klocke, EE, Upchurch, DA, Comroe, AJ, Jugan, MC, Mason, DE, Orchard, RJ, Klutzke, JB, Fitzgerald, AH, Woodruff, K. Long-acting injectable methadone (methadone-fluconazole) provides safe and effective postoperative analgesia in a randomized clinical trial for dogs undergoing soft tissue surgery. Am J Vet Res. 2022, 83(8), ajvr.22.01.0014.
KuKanich B, KuKanich K, Locuson CW, Rankin DC, Fitzgerald AH, Cho P, Komp MS. Multiple-dose pharmacokinetics and opioid effects of a novel analgesic with a deterrent to human opioid abuse (methadone-fluconazole-naltrexone) after oral administration in dogs. Mar;82(3):171-180. doi: 10.2460/ajvr.82.3.171. PMID: 33629900.
KuKanich K, Woodruff K, Bieberly Z, Papich MG, KuKanich B. Evaluation of urine concentrations of amoxicillin and clavulanate in cats. J Vet Intern Med. 2021 Jan;35(1):456-461. doi: 10.1111/jvim.15991. Epub 2020 Dec 6. PMID: 33280171; PMCID: PMC7848311.
KuKanich KS, Bagladi-Swanson M, KuKanich B. Pseudomonas aeruginosa susceptibility, antibiogram and clinical interpretation, and antimicrobial prescribing behaviors for dogs with otitis in the Midwestern United States. J Vet Pharmacol Ther. 2022 Jun 13. doi: 10.1111/jvp.13077. Epub ahead of print. PMID: 35698441.
KuKanich B, KuKanich K, Rankin DC, Upchurch DA, Comroe A, Crauer B, Berke K, Klocke EE, Gonzalez SE, Mason D, Jensen G, Orchard R, Fitzgerald AH, Cho P, Komp M. Perioperative analgesia associated with oral administration of a novel methadone-fluconazole-naltrexone formulation in dogs undergoing routine ovariohysterectomy. Am J Vet Res. 2020 Sep;81(9):699-707. doi:10.2460/ajvr.81.9.699. PMID: 33112167.
KuKanich B, KuKanich K, Rankin DC, Locuson CW, Joo H. Pharmacokinetics and pharmacodynamics of a novel analgesic with a deterrent to human opioid abuse (methadone-fluconazole-naltrexone) after oral administration in dogs. Am J Vet Res. 2020 Aug;81(8):656-664. doi: 10.2460/ajvr.81.8.656. PMID: 32700999.
KuKanich K, KuKanich B, Lin Z, Rankin AJ, Hanzlicek AS, Palerme JS, Bach J, Cook AK, Juracek A, Joo H. Clinical pharmacokinetics and outcomes of oral fluconazole therapy in dogs and cats with naturally occurring fungal disease. J Vet Pharmacol Ther. 2020 Nov;43(6):547-556. doi: 10.1111/jvp.12888. Epub 2020 Jul 12. PMID: 32656792.
Berke K, KuKanich B, Orchard R, Rankin D, Joo H. Clinical and pharmacokinetic interactions between oral fluconazole and intravenous ketamine and midazolam in dogs. Vet Anaesth Analg. 2019 Nov;46(6):745-752. doi: 10.1016/j.vaa.2019.06.007. Epub 2019 Jul 17. PMID: 31401049.
KuKanich B, KuKanich K, Rankin D, Locuson CW. The effect of fluconazole on oral methadone in dogs. Vet Anaesth Analg. 2019 Jul;46(4):501-509. doi: 10.1016/j.vaa.2019.02.003. Epub 2019 Feb 19. PMID: 30982709.
KuKanich K, KuKanich B, Slead T, Warner M. Evaluation of drug content (potency) for compounded and FDA-approved formulations of doxycycline on receipt and after 21 days of storage. J Am Vet Med Assoc. 2017 Oct 1;251(7):835-842. doi: 10.2460/javma.251.7.835. PMID: 28967825.
KuKanich B, KuKanich K, Black J. The effects of ketoconazole and cimetidine on the pharmacokinetics of oral tramadol in greyhound dogs. J Vet Pharmacol Ther. 2017 Dec;40(6):e54-e61. doi: 10.1111/jvp.12424. Epub 2017 Jun 11. Erratum in: J Vet Pharmacol Ther. 2018 Apr;41(2):354. PMID: 28603935.
KuKanich B. Pharmacokinetics and pharmacodynamics of oral acetaminophen in combination with codeine in healthy Greyhound dogs. J Vet Pharmacol Ther. 2016 Oct;39(5):514-7. doi: 10.1111/jvp.12299. Epub 2016 Feb 20. PMID: 26896302.
KuKanich K, KuKanich B, Guess S, Heinrich E. Effect of Sucralfate on the Relative Bioavailability of Enrofloxacin and Ciprofloxacin in Healthy Fed Dogs. J Vet Intern Med. 2016 Jan-Feb;30(1):108-15. doi: 10.1111/jvim.13796. Epub 2015 Dec 9. PMID: 26651022; PMCID: PMC4913628.
Benitez ME, Roush JK, KuKanich B, McMurphy R. Pharmacokinetics of hydrocodone and tramadol administered for control of postoperative pain in dogs following tibial plateau leveling osteotomy. Am J Vet Res. 2015 Sep;76(9):763-70. doi: 10.2460/ajvr.76.9.763. PMID: 26309104.
Benitez ME, Roush JK, McMurphy R, KuKanich B, Legallet C. Clinical efficacy of hydrocodone-acetaminophen and tramadol for control of postoperative pain in dogs following tibial plateau leveling osteotomy. Am J Vet Res. 2015 Sep;76(9):755-62. doi: 10.2460/ajvr.76.9.755. PMID: 26309103.
Norkus C, Rankin D, KuKanich B. Evaluation of the pharmacokinetics of oral amitriptyline and its active metabolite nortriptyline in fed and fasted Greyhound dogs. J Vet Pharmacol Ther. 2015 Dec;38(6):619-22. doi: 10.1111/jvp.12237. Epub 2015 May 18. PMID: 25989225.
KuKanich B, KuKanich K. Chloramphenicol significantly affects the pharmacokinetics of oral methadone in Greyhound dogs. Vet Anaesth Analg. 2015 Nov;42(6):597-607. doi: 10.1111/vaa.12257. Epub 2015 Mar 2. PMID: 25733012.
Norkus C, Rankin D, KuKanich B. Pharmacokinetics of intravenous and oral amitriptyline and its active metabolite nortriptyline in Greyhound dogs. Vet Anaesth Analg. 2015 Nov;42(6):580-9. doi: 10.1111/vaa.12248. Epub 2015 Feb 14. PMID: 25683584.
Norkus C, Rankin D, Warner M, KuKanich B. Pharmacokinetics of oral amantadine in greyhound dogs. J Vet Pharmacol Ther. 2015 Jun;38(3):305-8. doi: 10.1111/jvp.12190. Epub 2014 Nov 27. PMID: 25427541.
KuKanich K, KuKanich B. The effect of sucralfate tablets vs. suspension on oral doxycycline absorption in dogs. J Vet Pharmacol Ther. 2015 Apr;38(2):169-73. doi: 10.1111/jvp.12165. Epub 2014 Sep 18. PMID: 25233871.