College of Veterinary Medicine

John Bates

John BatesResearch Assistant Professor

Degrees

1998 B.S. Biochemistry, Mississippi State University
2005 Ph.D. Microbiology, The University of Alabama at Birmingham

Contact

208 Coles Hall
785-532-4527
jtbates @vet.k-state.edu

Research Interests

I am working on developing vaccines to protect against human pathogens and economically important animal pathogens. My interests include understanding the biological mechanisms of how adjuvants work as well as designing and developing novel live and subunit vaccine platforms.

Publications

Dulek DE, Newcomb DC, Toki S, Goliniewska K, Cephus J, Reiss S, Bates JT, Crowe JE Jr., Boyd KL, Moore ML, Zhou W, Peebles RS Jr. 2014. Stat4-deficiency Fails to Induce Th2 or Th17 Immunity with Primary or Secondary Respiratory Syncytial Virus Challenge but Enhances the RSV-specific Lung CD8+ T cell Immune Response to Secondary Challenge. Journal of Virology. 88(17):9655-72.

Bates JT, Keefer CJ, Kulp DW, Slaughter JC, Schief WR, Crowe JE Jr. 2014. Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein. Virology. 454-455:139-44.

Correia BE, Bates JT, Loomis R, Baneyx G, Jardine JG, Rupert P, Carrico C, Correnti C, Kalyuzhniy O, Vittal V, Li Y, Connel MJ, Stevens E, Schroeter A, MacPherson S, Serra AM, Adachi Y, Klevit RE, Wyatt RT, Baker D, Strong RK, Crowe JE Jr, Johnson PR, Schief WR. 2014. Proof of principle for epitope-focused vaccine design. Nature. 507(7491): 201-6.

Bates JT, Keefer JC, Utley TJ, Correia BE, Schief WR, Crowe JE Jr. 2013. Reversion of somatic mutations of the respiratory syncytial virus-specific human monoclonal antibody Fab19 reveal a direct relationship between association rate and neutralizing potency. The Journal of Immunology. 190: 3732-3739.

Zeitlin L, Bohorov O, Bohorova N, Hiatt A, Kim DH, Pauly MH, Velasco J, Whaley KJ, Barnard DL, Bates JT, Crowe JE Jr, Piedra PA, Gilbert BE. 2013. Prophylactic and therapeutic testing of Nicotiana-derived anti-RSV human monoclonal antibodies in the cotton rat model. m Abs 5: 263-269.

Bates JT, Graff AH, Phipps JP, Grayson J, Mizel SB. 2011. Enhanced antigen processing of flagellin fusion proteins promotes the antigen-specific CD8+ T cell response independently of TLR5 and MyD88. The Journal of Immunology 186: 6255-6262.

Mizel S Band Bates JT. 2010. Flagellin as an adjuvant: cellular mechanisms and potential. The Journal of Immunology 185: 5677-5682.

Bates JT, Uematsu S, Akira S, Mizel SB. 2009. Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin. The Journal of Immunology 182: 7539-7547.

Bates JT, Honko AN, Graff AH, Kock ND, Mizel SB. 2008. Mucosal adjuvant activity of flagellin in aged mice. Mechanisms of Ageing and Development 129: 271-281.

Zhang Z, Swindle CS, Bates JT, Ko R, Cotta CV, Klug CK. 2007. Expression of a non-DNA-binding isoform of Helios induces T cell lymphoma in mice. Blood 109: 2190-2197.

Bates JT and Bucy RP. 2005. Enhanced responsiveness to antigen contributes more to immunological memory in CD4 T cells than increases in the number of cells. Immunology 116: 318-327.