Anatomy and Physiology

Cell & Molecular Biology Department - St. Jude Children's Research Hospital

“Disturbance of RNA-protein assemblies underlies ALS and related diseases”
February 20th, 2018 at 4:00 p.m.
Mara Conference Center, Trotter Hall

J. Paul Taylor, M.D., Ph.D. is an Investigator of the Howard Hughes Medical Institute and the Edward F. Barry Endowed Chair in Cell and Molecular Biology at St. Jude Children’s Research Hospital. He received his M.D. and Ph.D. degrees from Jefferson Medical College, trained as a resident in Neurology at the University of Pennsylvania and as a Postdoctoral Fellow in Neurogenetics at NINDS/NIH. Dr. Taylor is a longstanding member and current Chair of the NIH study section in Cellular and Molecular Neurodegeneration. He serves as a reviewing editor for eLife and Deputy Editor-in-Chief of Brain Research. Dr. Taylor co-organized the RNA Metabolism in Neurological Disease meetings in 2011, 2013, 2015, 2016 and 2018, as well as the Gordon Research Conference on ALS and related diseases that will take place in July 2019. His research program focuses on the molecular basis of inherited neurological disorders with current emphasis on the multisystem proteinopathies ALS, FTD and IBM. Dr. Taylor is pursuing the hypothesis that these diseases are driven by a disturbance in the dynamics and material properties of liquid cellular assemblies built from low complexity sequence domains.

Theodore F. Hubbard Professor of Cardiovascular Research, University of Nebraska Medical Center

“Targeting Dorsal Root Ganglia in Cardiovascular Disease”
October 3, 2016 at 4:30 p.m.
Mara Conference Center, Trotter Hall

Irving H. Zucker, Ph.D. is the Theodore F. Hubbard Professor of Cardiovascular Research and Chairman of the Department of Cellular and Integrative Physiology at the University of Nebraska Medical Center in Omaha, Nebraska. He has been Chairman since 1989. Dr. Zucker received his Ph.D. from New York Medical College in 1972. He continued his post doctoral training at the University of Nebraska Medical Center where he became a faculty member in 1973.

Keck School of Medicine, University of Southern California

“Salt Transporters in the Kidney During Hypertension: Matching Na Output to Na Intake”
May 4, 2015 at 4:30 p.m.
Mara Conference Center, Trotter Hall

Dr. Alicia McDonough is Professor of Cell and Neurobiology at the University of Southern California, Keck School of Medicine. The McDonough laboratory examines, at the cellular level, how the kidneys respond to hypertension to bring blood pressure and fluid volume back to normal, and why this response does not occur in chronic hypertension. For this body of work, Dr. McDonough was awarded the Ernest H. Starling Distinguished Lectureship from the American Physiological Society. Her lab also examines how the gut, muscles, and kidneys work together to maintain potassium balance, which affects blood pressure and kidney health.

The McDonough lab initiated studies to determining the renal mechanisms responsible for regulation of sodium, blood pressure, and potassium balance, and how homeostasis is disrupted in disease states and corrected therapeutically. By investigating ion transporters’ phosphorylation, abundance, subcellular distribution and activity, the lab has more recently defined how stimuli such as dietary sodium and potassium, AngII, injury, and cytokines increase renal sodium transport, and how the resultant hypertension provokes intrarenal responses to decrease sodium reabsorption (via pressure natriuresis).

Dr. McDonough earned an A.B. in Physiology at the University of California Berkeley, a Ph.D. in Physiology at the University of Hawaii, and was a Postdoctoral Scholar at the University of California San Francisco Cardiovascular Research Institute and at Columbia University under the mentorships PS Timiras, SK Hong and IS Edelman, respectively.

Dr. McDonough was an American Heart Association Established Investigator recipient and is active in the Kidney and Cardiovascular Disease Council. She has received two Outstanding Teacher awards for instructing first- and second-year Keck Medical students in renal physiology.

We appreciate that Dr. McDonough will present the Dr. Rudolf Clarenburg Lectureship in the College of Veterinary Medicine at Kansas State University. We hope that you will attend her lecture.

University of Pennsylvania School of Medicine

“Emergent Properties of Single Cells: Dynamical Systems Analysis”
December 9, 2013 at 3:30 p.m.
Mara Conference Center, Trotter Hall

Dr. Eberwine is the Elmer Holmes Bobst Professor of Pharmacology at the University of Pennsylvania where he also serves as Co-Director of the PENN Genome Frontiers Institute. Dr. Eberwine coined the phrase “expression profile” to describe the relative abundances of RNAs. Further he and his colleagues were the first to identify the large complexity of RNAs that are targeted to neuronal dendrites; directly demonstrate protein synthesis in dendrites; prove that membrane proteins could be synthesized in dendrites and inserted into the membrane to form functional receptors; identify the largest verified lists of in vivo RNA cargoes for specific RNA binding proteins; to demonstrate the capacity for and functional requirement for dendritic splicing of RNAs and to show that RNA expression profiles could be transferred between cells carrying their phenotypic memory with them. These research accomplishments were possible because of technology developed by Dr. Eberwine including: single cell PCR, the aRNA procedure, the phototransfection methodology, the PAIR procedure and the functional genomics TIPeR methodology as well as other single cell analysis technologies. Dr. Eberwine is an inventor on over sixty patents and has founded three biotech companies while serving on the Scientific Advisory Board for three additional companies. Dr. Eberwine has served as a member of the Board of Scientific Counselors for NIDA and is a member of the Scientific Advisory Board for the EP Abraham Trust Fund of Sir William Dunn School of Pathology, Oxford University.

Dr. Eberwine originated and directed the Cold Spring Harbor Summer Course formerly entitled “Cloning of Neural Genes” and now called “Advanced Techniques in Neuroscience”. Dr. Eberwine has directed or taught in this course 19 times over its’ 24year history. In 2012, he developed and Co-Directed the first Cold Spring Harbor Course on “Single Cell Techniques”. Dr. Eberwine has taught molecular biology in courses around the World including in Mexico, Germany, England and Brazil.

Dr. Eberwine has given many named lectureships and received various awards for his scientific accomplishments including a NARSAD Distinguished Investigator Award, a MERIT award from NIH, the NIH Pioneer Award, an Ellison Foundation Senior Scholar Award and the McKnight Technological Innovations in Neuroscience Award.

We appreciate that Dr. Eberwine will present the Dr. Rudolf Clarenburg Lectureship in the College of Veterinary Medicine at Kansas State University. We hope that you will attend his lecture.

Professor of Medicine and Microbiology
University of Alabama at Birmingham

“Maintaining Immunologic Peace with Microbiota”
September 20, 2012 at 3:30 p.m.
Mara Conference Center, Trotter Hall

Dr. Charles O. Elson, M.D., is the Basil I. Hirschowitz Chair of Gastroenterology, Professor of Medicine in the Division of Gastroenterology and a professor in the Department of Microbiology at the University of Alabama at Birmingham. He received his M.D. from Washington University in St. Louis, trained in Internal Medicine at New York Hospital/Cornell, then did his Gastroenterology fellowship at the University of Chicago. After doing full-time research in immunology at N.I.H., he joined the Faculty of the Division of Gastroenterology at the Medical College of Virginia. He moved to the University of Alabama at Birmingham to become the Director of the Division of Gastroenterology and Hepatology, and subsequently served as Vice-Chair for Research in the Department of Medicine. He holds the Basil I. Hirschowitz Chair in Gastroenterology and is an active consultant in immune-mediated intestinal disorders.

The author of numerous peer-reviewed manuscripts, reviews, and book chapters, Dr. Elson has held major positions in national organizations, and has served on a number of advisory boards, including the Advisory Council of the National Institute of Diabetes and Digestive and Kidney Diseases.

He has been elected to many of the most outstanding professional societies in the field of academic medicine, and has a long history of service to the Society for Mucosal Immunology for which he is a co-founder and past president.

The central focus of the Elson laboratory is on the regulation of mucosal immune responses, particularly the mucosal immune response to the microbiota, which represent the largest mass of antigen encountered by the immune system. The cellular and molecular mechanisms that maintain mucosal immune homeostasis are being defined. When these mechanisms fail, pathogenic effector T cells are generated that result in colitis. Dr Elson and co-workers have cloned a set of immunodominant antigens of the microbiota that stimulate such pathogenic T cells and result in inflammatory bowel disease. Among these cloned antigens, previously unknown bacterial flagellins have emerged as a major cluster. Seroreactivity to these flagellins is found in multiple experimental models of colitis in mice and in half of patients with Crohn’s disease. These antigens drive a newly described CD4 T cell effector subset making IL-17 (Th17) which appears to be responsible for disease progression. A T cell receptor transgenic mouse reactive to the flagellins has been generated and is being used to study the innate and adaptive immune response to microbiota antigens. A second major effort is in the identification of T reg cells in the intestine that recognize microbial antigens and maintain homeostasis. The mechanisms whereby such cells are induced are being defined and the application of these cells to prevent or treat intestinal inflammation are being tested.

We appreciate that Dr. Elson will present the Dr. Rudolf Clarenburg Lectureship in the College of Veterinary Medicine at Kansas State University. We hope that you will attend his lecture.

Wyatt and Susan Haskell Endowed Professor in Medical Excellence
School of Medicine, University of Alabama at Birmingham

“The Emergence of the Th17 Pathway; Implications for Host Protection and Autoimmunity”
November 9, 2009 at 3:30 p.m.
Practice Management Center – Trotter Hall

Dr. Weaver received his M.D. with honors in 1984 from the University of Florida in Gainesville and his board certification from the American Board of Pathology in Anatomic Pathology in 1993.

The goal of Dr. Weaver’s research is advancement in understanding mechanisms by which CD4 T cells develop into distinct functional subsets and how these subsets control immune responses. Dr. Weaver’s group has pioneered methods for defining and tracking CD4 T cell development and modeling of inflammatory bowel disease (IBD).

Additional research efforts are focused on three interrelated themes: the molecular mechanisms that controls developmental decisions that specify Th17 and Treg development; delineation of mechanisms by which innate immune cells respond to pathogenic and commensal bacteria to shape Th17 versus Treg development; and a dissection of contributions of cis regulatory elements in controlling key cytokines produced by CD4 T cells – all with a view towards defining novel interventions to better prevent or treat immune-mediated diseases.

We are grateful that Dr. Weaver will present The Dr. Rudolf Clarenburg Lectureship in the College of Veterinary Medicine at Kansas State University. We hope that you will attend his lectures.

Washington University School of Medicine

Two Lectures:
“The Molecular Basis of Potassium ATP Channel Activity”
October 27, 2008 at 3:30 p.m.

“Electrical Signaling: from Molecules to Malaise”
October 28, 2008 at 10:00 a.m.
Practice Management Center – Trotter Hall

Colin G. Nichols, Ph.D., is the Carl Cori Professor in the Department of Cell Biology and Physiology at Washington University School of Medicine. He received a BSc in Biochemistry and Physiology, and a Ph.D. in Physiology, from Leeds University in England. He then completed a post-doctoral fellowship in the Department of Physiology at the University of Maryland and joined the Washington University School of Medicine faculty in 1991.

Dr. Nichols’ research focuses on the biology of ion channels, and their role in linking cellular metabolism to electrical activity in various tissues. His major discoveries have included the molecular mechanism of inward rectification, and the electrical basis of neonatal diabetes. Supported by grants from the National Institutes of Health and the American Diabetes Association, he was also an Established Investigator of the American Heart Association, and an inaugural honoree as a Fellow of the American Heart Association. He has served on the editorial boards of Biophysical Journal, Circulation Research, Journal of General Physiology and Channels. He has also served as Chair of the Membrane Biophysics Sub-Group of the Biophysical Society, and as President of the Society of General Physiologists.

For more information about Dr. Nichols please visit his webpage at http://www.nicholslab.wustl.edu/

We are grateful that Dr. Nichols will present The Dr. Rudolf Clarenburg Lectureship in the College of Veterinary Medicine at Kansas State University. We hope that you will attend his lectures.

University at Buffalo, State University at New York

Two lectures:
"Oral and Systemic Disease: Crossing the Barriers of Interdisciplinary Research in Academic Health Centers"
April 14, 2008 at 4:00 p.m.

"Transfer of University Discoveries to Society: New Approaches and Early Results at the University at Buffalo"April 15, 2008 at 2:00 p.m.

Practice Management Center - Trotter Hall

Dr. Genco received his D.D.S. cum laude, from the State University of New York at the Buffalo School of Dentistry in 1963. He received his Ph.D. from the University of Pennsylvania, in Microbiology and Immunology in 1967 and completed residency training in periodontology at the University of Pennsylvania in 1967.

Dr. Genco is a Distinguished Professor in the Department of Oral Biology, School of Dental Medicine, and in the Department of Microbiology, School of Medicine and Biomedical Sciences at the State University of New York at Buffalo. He also is a Professor in The Department of Immunology at the Roswell Park Cancer Institute. Dr. Genco has been a member of the Institute of Medicine. National Academy of Sciences since 1988.

Dr. Genco's research and clinical activities focus on studies of oral infections, specifically the role of oral flora in periodontal diseases. Most recently, Dr. Genco has been studying the effects of oral infections on cardiovascular and cerebrovascular disease, as well as the effects of oral infection on glycemic control and complications of diabetes mellitus including cardiovascular and kidney disease.

Dr. Genco is the Vice Provost responsible for the University at Buffalo Office of Science, Technology Transfer, and Economic Outreach (STOR). STOR promotes economic revitalization through transfer and economic outreach activities. and fosters partnerships between the university and the business community.

National Heart, Lung and Blood Institute, NIH
Bethesda, Maryland.

"Aquaporins in Health and Disease"
November 29, 2006 at 4:00 p.m.
Practice Management Center, Trotter Hall

Alumni Endowed Professor of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO.

Research in Dr. Nerbonne’s laboratory is focused primarily on delineating the mechanisms involved in the regulation and modulation of voltage gated ion channels in cardiac myocytes and cortical neurons. In myocytes, her interest is in the Ca++ independent depolarization activated K+ channels that determine the height and the duration of the cardiac action potential. In addition to examining the electrophysiological properties of these channels, she is exploring the molecular basis of the functional diversity of K+ channels found in cardiac cells and the molecular mechanisms controlling the regulation of functional K+ channel expression in the normal as well as the diseased heart. She is also exploring dominant negative strategies to effect the functional knockout of K+ channels in the mouse heart and examining the physiological and pathophysiological consequences of these manipulations.

Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa

"Contrasts in Biomedical Research and Health Care: Sweden and USA."
April 29, 2002 4:00 p.m.
Practice Management Center, Trotter Hall

The Department of Anatomy & Physiology College of Veterinary Medicine present the Rudy Clarenburg Distinguished Lecture Series. This spring's lecture series features Dr. George A. Brooks. Dr. George Brooks will be presenting two lecture series on Monday, March 12 and Tuesday, March 13 at the Practice Management Center, Trotter Hall at 4:00 PM.

March 12: "Fuel Utilization During Exercise: The Crossover Concept."
March 13: "Exercise Substrate Utilization: The Lactate Shuttle."

Dr. George A. Brooks is presently Professor and Director of the Exercise Physiology Laboratory in the Department of Integrative Biology at the University of California at Berkeley. Dr. Brooks received his PhD from the University of Michigan in 1970 and then completed a Post-Doctoral Fellowship at Muscle Biology Research Laboratory located at the University of Wisconsin, Madison. Dr. Brooks is an established, internationally recognized muscle physiologist. He has been continually funded by the NIH for nearly 25 years and has published over 175 manuscripts in top-quality peer-reviewed physiology and biochemistry journals. We are grateful that Dr. Brooks has accepted the invitation to present the Rudy Clarenburg Lecture Series here in the College of Veterinary Medicine at Kansas State University. For more information about Dr. Brooks, you can view his webpage at http://ib.berkeley.edu/labs/brooks/