Dr. Rahul Nandre, postdoctoral research associate received a Travel Grant Award from the Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference. This conference will be held at Washington, D.C. June 28-30. The VASE conference is organized by PATH, an international nonprofit organization that drives transformative innovation to save lives and improve health, is convening a new biennial scientific conference focused on making vaccines for Shigella and enterotoxigenic Escherichia coli (ETEC) in the developing world. Dr. Nandre would like to thank to his superviser Dr. Weiping Zhang, professor in DMP, who guided him for post-doctoral research.

Fourth-year student Caroline Meyer received a KSU Extraordinary Student Award designed to recognize and honor students who have shown extraordinary courage and persistence in the pursuit of their education. Caroline finishes all DVM requirements on May 1.

The Exotic Companion Mammal Symposium was held at the College of Veterinary Medicine. The conference was organized by and sponsored by Oxbow Animal Health. Dr. James W. Carpenter and Ashley McCowan were the local hosts and organizers. More than 90 veterinarians, technicians and veterinary students attended. Speakers included Drs. Natalie Antinoff (Keynote Speaker; Gulf Coast Veterinary Specialists, Houston), Micah Kohles (KSU DVM ’01, Oxbow), James W. Carpenter, and David Eshar. The symposium was RACE approved.

Dr. Anne Sally Davis, diagnostic medicine/pathobiology department, received $3,000 from the Kansas State University Office of International Programs in its spring 2016 Incentive Grant awards. Grant awards can be used by faculty to develop international collaborations, research, teaching and study abroad opportunities, as well as elevate international global learning opportunities and experimental short term co-teaching grants. Dr. Davis was awarded for a Rift Valley Fever Virus research collaboration with the University of Pretoria. Dr. Davis also reports a recent first-author publication, "1918 Influenza receptor binding domain variants bind and replicate in primary human airway cells regardless of receptor specificity."

Dr. Roman Ganta will serve as the chair for the National Institutes of Health special emphasis panel for reviewing R15 Academic Research Enhancement Award applications. Application topics include virology, bacteriology, parasitology, vector biology and drug discovery. Ganta will serve in July and November 2016.

Dr. Bob Larson presented at the National Institute for Animal Agriculture in Kansas City, Missouri, on BVD consult.

Dr. Mike Apley met with veterinarians in the swine executive veterinarian program at the University of Illinois. His topics were the veterinary feed directive, antibiotic resistance, upcoming changes in regulations, and antibiotic stewardship. He also spoke at the Colorado Livestock meeting in Loveland. He was on a panel on consumer communications regarding major issues involving beef production.

Dr. Walter Renberg presented at the WVC Oquendo Center in Las Vegas. He presented topics in hind-limb orthopedic surgery.

Dr. David Biller presented at the Federation of Asian small animal veterinarians meeting in Kuala Lampur, Malaysia. His topics were on interpretation of a normal thorax; abnormal pulmonary patterns; radiographic techniques; and understanding contrast studies.

Dr. David Eshar presented at the Paris University. Topic: GI-stasis in rabbits. He also attended the European College of Zoo Medicine Meeting in Mons, Belgium. Topic: Evaluation of the effects of body position on trends of selected physiological parameters during isoflurane anesthesia in black-tailed prairie dogs.

Amy Brusk presented at the Region IV National Council of University Research Administrators in Kansas City on Monday, May 2. Her presentation title was: “Today’s Research Environment: Implications for Research Administrators”

Kristin Loving gave a presentation on Willie's Pet of the Week and "Bringing Your Brand to Life Through Social Media" at the University Communicators conference at the Harvard Faculty Club in Cambridge, Massachusetts, held April 12-13.

Class of 2018 surprises Dr. Steve Stockham

The class of 2018 surprised Dr. Steve Stockham, who is retiring this summer. Dustin Renken announced the class is going to have a stone installed in honor of Dr. Steve Stockham in the Centennial Plaza – it will be placed in about the location he usually stands when he lectures outdoors on the plaza. A video of the presentation is posted at this Facebook link.

CORE program hosts special seminar by Dr. Stuart Reid

Dr. Stuart Reid, dean of the University of London Royal Veterinary College, presented a K-State Distinguished Lecture on April 25, in Frick Auditorium. His lecture was titled "One Health, antimicrobial wars and the resistance movement." Dr. Reid is world renowned as a population health specialist and leader in the development of interdisciplinary programs that advance the mission of academic institutions while positively impacting the local and global communities. He was hosted by CORE, the Center for Outcomes and Research Education in the College of Veterinary Medicine.

Developing Scholars Research Symposium features several CVM participants

Undergraduate research took enter stage at Kansas State University's 16th annual Developing Scholars Program Research Poster Symposium on April 17 in the K-State Student Union's Ballroom.

The Developing Scholars Program is an undergraduate research program that provides opportunities for highly motivated students from diverse backgrounds to participate in research projects with a faculty mentor. Students receive academic, social and financial support while participating in the discovery and creation of new knowledge at Kansas State University. Developing Scholars is housed in the university's Office of Undergraduate Research & Creative Inquiry.

"The Developing Scholars Symposium has become an anticipated spring tradition at K-State where the campus and community come together to celebrate the diverse contributions of Kansas State undergraduates and their faculty research mentors," said Anita Cortez, director of the Office of Undergraduate Research & Creative Inquiry. "Their research ranges from cutting edge cancer research to prison reform to food insecurity in Kansas to marketing of toys to girls. We encourage all undergraduates to seek out research opportunities while they are at K-State surrounded by so many gifted faculty. K-State's faculty are well known for their generous support of undergraduates in research."

Below is a list of student participating at the CVM and their mentors:

Eric Charboneau, Michael Zuniga and Jake Jimenez: Dr. Mark Weiss (our longest serving mentor)

Patrick Guvele: Nancy Monteiro-Riviere

Mya Masterson: Dr Sally Davis

Tera Brandt: Dr. Tom Schermerhorn

Carolina Garcia: Dr. Weiping Zhang

Melissa Riley: Dr. Bruce Schultz

Maira Cotton-Caballero: Dr. Bonto Faburay

Jennifer Delzeit: Dr. Masaaki Tamura

Delia Hernandez: Dr. Peying Fong

Miriam Macedo: Dr. Deryl Troyer

Arisa Yamashita: Dr. John Gonzalez (ASI)

Mya Masterson has worked with Dr. Sally Davis, who said, "Mya is a wonderful addition to our lab. She has a great attitude and energy level. I’m particularly proud of her ability to pick-up complex immunohistochemical techniques at the bench and her flexibility and perseverance with her project which suffered interruptions unrelated to her laboratory work. She put together a wonderful poster summarizing her work to date on her project. I look forward to her continuing this work and other projects in the fall.”

Patrick Guvele, an undergraduate student working in Dr. Nancy Monteiro-Riviere’s lab at the NICKS Center, receives an Honorable Mention Award at the Developing Scholars ceremony.

Maira Cotton-Caballero works in Dr. Bonto Faburay's lab on "Expression of Recombinant Nucleocapsid (N) and Spike (S1) Proteins of Avian Infectious Bronchitis Virus and Their Assessment as Diagnostic and Subunit Vaccine Antigens."

CVM holds annual White Coat Ceremony - Congrats and Good Luck to class of 2017

The Nanotechnology Innovation Center and the Institute of Computational Comparative Medicine Faculty and Postdoctoral Awards, Grants, Book Chapters and Publications from January 2016 - April 2016

Honors and Awards:

1. Dr. Nancy Monteiro-Riviere was selected as an “Eminent Toxicologist” because of her major contribution to the science of toxicology and engaging ability as a public speaker. Her lecture on “Frontiers in Nanotoxicology of the Skin” was videotaped and archived in the Eminent Toxicologist Series to incorporate prominent toxicologists who have created history.
2. Dr. Butch KuKanich served on the KSU’s Mentoring Fellowship program for Dr. David Eshar on the grant: “Pharmacokinetics of one antibiotic drug (enrofloxacin) and one analgesic/anti-inflammatory drug (meloxicam) in zoo-kept black-tailed prairie dogs”.
3. Dr. Aryal, Graduate Student Summer Stipend for $ 4807.00 for T.Nguyen. Ms. Nguyen also received the Phi Lambda Upsilon award.
4. Dr. A. Pitchaimani, a postdoctoral fellow under Dr. Aryal received a $1000 travel award.
5. Dr. Nancy Monteiro-Riviere was Chairperson of the Alternative In Vitro Toxicity Models Session at The 55^th Annual Meeting of the National Society of Toxicology, New Orleans, LA. March 16, 2016.
6. Dr. Parwathy Chandran, a postdoctoral fellow under Dr. Nancy Monteiro-Riviere received the Outstanding Postdoctoral Award at the Nanotoxicology Specialty Section at the 55^th National Society of Toxicology, New Orleans, LA, March16, 2016.
7. Drs. Lin, Monteiro-Riviere NA, Riviere JE received an Honorable Mention for best paper from the Biological Modeling Specialty Section of the National Society of Toxicology entitled “A physiologically based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice”. Nanotoxicology 10(2):162-172, 2016.
8. Drs. Lin, Monteiro-Riviere NA, Riviere JE publication “Pharmacokinetics of metallic nanoparticles” in WIREs Nanomedicine and Nanobiotechnology, 7(2):189-217, 2015 was listed in the Top Ten most accessed paper.
9. Dr. Nancy Monteiro-Riviere was Chair of the National Institute of Environmental Health Sciences (NIEHS) Special Emphasis Panel on Engineered Nanomaterials Grant Applications for UO1. April, 2016.
10. Dr. Jim Riviere completed a year-long critical review of the USDA/FSIS National Residue Program for Meat, Poultry and Egg Products (2014-2015) released by the Pew Charitable Trusts on March 8, 2016.
11. Patrick Guvele, an undergraduate student working in Dr. Monteiro-Riviere’s lab at the NICKS Center, received an Honorable Mention at the 16^th Annual Developing Scholars Program Research Symposium at KSU on April 17, 2016.

Grants:

1. Dr. Aryal received a seed grant for from the Johnson Cancer Research Center. "Engineering Biomimetic Theranostic Nanoconstruct for the Treatment and Diagnosis of Breast Carcinoma".$20,000
2. Dr. Lin received a K-State Mentoring Fellowship. “An Integrative In Vitro and In Vivo Dosimetry Model for Engineered Nanomaterials” $6,000. Summer 2016 and 2017.

Research Publications:

1. Lin Z, Monteiro-Riviere NA, Riviere JE. A physiological based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice. Nanotoxicology 10: 162-172, 2016.
2. Lin Z, Monteiro-Riviere NA, Kanan R, Riviere JE. A computational framework for interspecies pharmacokinetics, exposure and risk assessment of gold nanoparticles. Nanomedicine 11: 107-119, 2016.
3. Shelver WL, Smith DJ, Tell LA, Baynes RE, Schroeder JW, Riviere JE. Screening and confirmatory analysis of flunixin in tissues and bodily fluids after intravenous or intramuscular administration of flunixin to cull dairy cows with or without lipopolysaccharide challenge.Journal Agricultural Food Chemistry 64 (1): 336-345, 2016.
4. DeDonder KD, Apley MD, Gehring R, Harhay DM, Lubbers BU, White BJ, Capik SF, KuKanich B, Riviere JE, Tessman RK. Pharmacokinetics and pharmacodynamics of gamithromycin in pulmonary epithelial lining fluid in naturally occurring bovine respiratory disease in multi-source commingled feedlot cattle. Journal of Veterinary Pharmacology Therapeutics 39: 157-166, 2016.
5. DeDonder KD, Gehring R, Riviere JE, Baynes RE, Tell LA, Vickroy TW. Residue concerns following exposure to livestock to oil and petroleum products. Letter. Journal of the American Veterinary Medical Association. 248: 145-146, 2016.
6. Choi K, Koci J, Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Mechanistic toxicity assessment of hexahydroisohumulone in canine hepatocytes, renal proximal tubules, bone marrow-derived mesenchymal stem cells and enterocyte-like cells. International Journal of Veterinary Health Science and Research (IJVHSTR) 4 (2): 88-103, 2016.
7. Williams FM, Rothe H, Barrett G, Chiodini A, Whyte J, Cronin MT, Monteiro-Riviere NA, Plautz J, Roper C, Westerhout J, Yang C, Guy RH. Assessing the safety of cosmetic chemicals: consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral Threshold of Toxicological Concern (TTC). Regulatory Toxicology and Pharmacology 76:174-186, 2016.
8. Baynes RE, Dedonder K, Kissell L, Mzyk D, Marmulak T, Smith G, Tell L, Gehring R, Davis J, Riviere JE. Health concerns and management of select veterinary drug residues. Food Chemical Toxicology 88:112-122, 2016.
9. Park S, Choi SO, Paik SJ, Choi S, Allen M, Prausnitz M. Intracellular delivery of molecules using microfabricated nanoneedle arrays. Biomedical Devices 18: 10-13, 2016.
10. Seeley KE, Wolf KN, Bishop MA, Turnquist M, KuKanich B. Pharmacokinetics of long-acting cefovecin in copper rockfish. American Journal Veterinary Research 77(3):260264, 2016.
11. KuKanich K, KuKanich B, Guess S, Heinrich E. Effect of sucralfate on the relative bioavailability of enrofloxacin and ciprofloxacin in healthy fed dogs. Journal of Veterinary Internal Medicine 30(1):108-115, 2016.
12. Gorden PJ, Kleinhenz MD, Wulf LW, KuKanich B, Lee CJ, Wang C, Coetzee JF. Altered plasma pharmacokinetics of ceftiofur hydrochloride in cows affected with severe clinical mastitis. Journal of Dairy Science 99(1):505-514, 2016.
13. Rankin AJ, Lanuza R, KuKanich B, Crumley WC, Pucket JD, Allbaugh RA, Meekins JM. Measurement of plasma gentamicin concentrations postchemical ciliary body ablation in dogs with chronic glaucoma. Veterinary Ophthalmology 19(1):57-62, 2016.
14. Nguyen T, Pitchaimani A, Koirala M, Muhammad F, Aryal S. Engineered biomimetic nanoabsorbent for cellular detoxification of chemotherapeutics. RSC Advances, 6: 33003-33008, 2016.
15. Poblete H, Agarwal A, Thomas S, Bohne C, Ravichandran R, Phospase J, Comer J, Alarcon EI. New insights into peptide-silver nanoparticle interaction: deciphering the role of cysteine and lysine in the peptide sequence. Langmuir 32:265-273, 2016.
16. Chen R, Wang B, Chen L, Cai D, Li B, Chen C, Huang E, Liu C, Lin Z, Xie WB, Wang H. DNA damage-inducible transcript 4 (DDIT4) mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes. Toxicology and Applied Pharmacology 295: 1-11, 2016.
17. Chen C, Qincao L, Xu J, Du S, Huang E, Liu C, Lin Z, Xie WB, Wang H. Role of PUMA in methamphetamine-induced neuronal apoptosis. Toxicology Letters 240: 149-160, 2016.
18. Cai D, Huang E, Luo B, Yang Y, Zhang F, Liu C, Lin Z, Xie WB, Wang H. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell Death and Disease 7: 1-14, 2016.
19. Krishna S, Lin Z, de La Serre CB, Wagner JJ, Harn DH, Pepples LM, Djani DM, Weber MT, Srivastava L, Filipov NM. Time-dependent behavioral, neurochemical, and metabolic dysregulation in female C57BL/6 mice caused by chronic high-fat diet intake. Physiology and Behavior157:196-208, 2016.
20. Pitchaimani A, Ngugyen T, Wang H, Bossman SH, Aryal S. Design and characterization of gadolinium infused theranostic liposomes. Royal Society of Chemistry Advances 6: 36898-36905, 2016.
21. Choi K, Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Oxidative stress response in canine in vitro liver, kidney, and intestinal models with seven potential dietary ingredients. Toxicology Letters 241: 49-59, 2016.
22. Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Toxicological effect of pet food ingredients on canine bone marrow derived mesenchymal stem cells and enterocyte-like cells. Journal Applied Toxicology 36 (2): 189-198, 2016.

Abstracts:

1. Choi K, Koci J, Ortega MT, Jeffery B, Riviere JE, Monteiro-Riviere NA. Mechanistic toxicity assessment of hexahydroisohumulone incanine hepatocytes, renal proximal tubules, and enterocyte like-cells. The Toxicologist 150, p.487, #3078, 2016.
2. Monteiro-Riviere NA, Ortega MT, Koci J, Lin Z, Jeffery B, Riviere JE. Comparative in vitro cytotoxicity of 20 potential food ingredients in canine liver, kidney, bone marrow-derived mesenchymal stem cells and enterocyte-like cells. The Toxicologist 150, p.487-488, #3079, 2016.
3. Sasidharan A, Monteiro-Riviere NA. Impact of the protein corona on the blood compatibility profile of gold nanoparticles. The Toxicologist 150, p.415, #2766, 2016.
4. Chandran P, Monteiro-Riviere NA. The effect of protein corona formation on the intracellular uptake profiles of gold nanoparticles in human primary vascular endothelial cells. The Toxicologist 150, p.413-414, #2760, 2016.
5. Zhang LO, Li J, He X, Lv X, Chen D, Li L, Chen C, Zhao Y, Wang F, Monteiro-Riviere NA, Guo Z. Mitochondria-targeted platinum coordination compounds may increase cell adhesion and inhibit migration. The Toxicologist 150, p.154, #1656, 2016.
6. Lin Z, Monteiro-Riviere NA, Kannan R, Riviere JE. A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles. The Toxicologist 150, p.117, #1504, 2016.
7. Muhammad F, Jaberi-Douraki M, de Souza D, Riviere JE. modulation of chemical dermal absorption by 14 natural products: a quantitative structure permeation (QSPR) analysis of components often found in topical cosmeceuticals. The Toxicologist 150, p. 590, #3512, 2016.
8. Nguyen T, Pitchaimani A, Koirala M, Aryal S. Engineering Biomimetic Nanoabsorbent for Detoxification of Chemotherapeutics. Capitol Graduate Research Summit, Topeka, KS, February 2, 2016.
9. Sridibhatla S, Nguyen T, Pitchaimani A, Koirala M, Aryal S. Bisphosphonate functionalized nanomedicine for targeting bone microenvironment. Capitol Graduate Research Summit, Topeka, KS, February 2, 2016.
10. Nguyen T, Pitchaimani A, Wang H, Bossmann S, Aryal S. Bone microenvironment targeted magnetic nanomedicine. K-State Graduate Research, Arts, and Discovery(GRAD) Forum, KSU, Manhattan, KS, March 2016.
11. Inchun N, Curtis C, Thomas S, Marroquin S, Hurst M, DeLong RK. Characterization of the interactions between model RNA, protein, and bio-relevant nanoparticles. ERN-Emerging Researchers National Conference in STEM, Washington, DC, 274:A239, 2016.
12. Ramani M and DeLong RK.Absorption mechanisms of poly I: c RNA onto zinc oxide nanoparticles:maximizing the payload. Experimental Biology 823.4: 261, 2016.
13. Thomas S, Marroquin S, DeLong RK. Elucidating the dynamics of nanoparticle-protein interaction at a biomolecular level: structural and functional studies using firefly luciferase. Experimental Biology 969.34: 323, 2016.
14. Wang H, Chen R, Chen L, Qiu P, Xu J, Huang E, Liu C, Lin Z, Xie W. DNA damage-inducible transcript 4 (DDIT4) mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes. The Toxicologist, 150, p. 433, #2843, 2016.
15. Xie W, Cai D, Qiao D, Yue X, Wang Q, Li D, Lin Z, Wang H. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. The Toxicologist, 150, p. 78, #1329, 2016.

Book Chapters:

1. Samberg ME, Lin Z, Monteiro-Riviere NA. In Vitro and In Vivo Toxicity and Pharmacokinetics of Silver Nanoparticles. In Encyclopedia of Nanotechnology (Ed. Bhushan, B.). Springer Science and Business Media, Dordrecht, pp.1-14, 2015. DOI: 10.1007/978-94-007-6178-0_331-2
2. Narayan RJ, Boehm RD, Monteiro-Riviere NA. Cell and Protein Interactions with Diamond. In Handbook of Clinical Medicine-Law, Business, Regulation, Safety and Risk, (Eds. Bawa R, Audette G, Reese BE), Vol.11, Section III-Health, Safety, Risk and Biological Interactions, Pan Stafford Publishing, Singapore, Chapter 33, pp.809-822, 2016.
3. Monteiro-Riviere NA. Safety of Nanoparticle Skin Penetration. In Percutaneous Penetration Enhancers-Chemical Methods in Penetration Enhancement-Nanocarriers Series (Eds. Dragicevic N and Maibach HI), Springer-Verlag Publishers, Heidelberg, Germany, Vol. 2, Chapter 24, pp. 363-376, 2016.

Invited Presentations:

1. Dr. Aryal “Rational Design of Polymeric Nanoparticle as a Theranostic Device”, Chonbuk National University, Jeonju, South Korea, April 2, 2016.

2. Dr. Aryal “Polymeric Nanomedicine as a Therapeutic and Diagnostic Modality”, Yonsei University, Wonju, South Korea, April 4, 2016.

3. Dr. Aryal “Polymeric Nanomedicine for Targeting Bone Microenvironment”, Polymer Society of Korea, Daejeon, South Korea, April 8, 2016.