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  7. »Dr. Victoriya Volkova

College of Veterinary Medicine

Dana L. Vanlandingham


Assistant Professor, Virology

PhD (2006), Liverpool School of Tropical Medicine, Liverpool UK
MS (1996), Colorado State University
BS (1993), Colorado State University

Office: 1039 BRI
Phone: 785-532-1369
Email: dlvanlan@vet.k-state.edu


My research is focused on the interactions between arboviruses, the mosquito vector, and the vertebrate host. We are investigating the molecular signatures associated with in vitro propagation verses a natural mosquito-vertebrate transmission cycle for Rift valley fever virus. We are also using infectious clone technology to identify the molecular determinants of infection of alphaviruses and flaviviruses. Our current work is focused on the yellow fever virus and the 17D vaccine to develop chimeric flavivirus infectious clones to examine the basis of viral dissemination of yellow fever virus in Ae. aegypti mosquitoes. Identification of the viral genes which inhibit infection and transmission of the vaccine strain will aid in the development of vaccines for other flaviviruses such as Japanese encephalitis. Additionally, I work on various projects involving arboviruses in collaboration with biotechnology companies; most recently I have assessed virus inactivation to ensure blood transfusion safety.


My teaching responsibilities involve mentoring graduate students in molecular arbovirology and entomology and assisting as a future instructor for Pathogenic Mechanisms of Viruses (DMP 910).

Selected publications

Rider, M., Zou, J., Vanlandingham, D.L., Nuckols, J., Higgs, S., Zhang, Q., Lacey, M., Kim, J., Wang, G., Hong, YS. 2013. Quantitative proteomic analysis of the Anopheles gambiae (Diptera: Culicidae) midgut infected with o’nyong-nyong virus. Journal of Medical Entomology. In press.

Tsetsarkin, K.A., Sampson-Johannes, A., Sawyer, L., Kinsey, J., Higgs, S. & Vanlandingham, D.L. 2013. Photochemical inactivation of chikungunya virus in human apheresis platelet components by amotosalen and UVA light.  American Journal of Tropical Medicine and Hygiene. In press.

Nuckols, J.T., Ziegler, S.A., Huang, Y-S.S., McAuley, A., Vanlandingham, D.L., Spratt, H., Davey, R.A., Higgs, S. 2012. Infection of Aedes albopictus with Chikungunya Virus Rectally Administered by Enema. Vector-Borne & Zoonotic Diseases 13(2):103-110.

Colpitts, T.M., Cox, J., Vanlandingham, D.L., Feitosa, F., Cheng, Kurscheid, S. Wang,P, Krishnan, M.N., Higgs, S., Fikrig, E Colpitts. 2011. Alterations in the Aedes aegypti transcriptome during infection with West Nile, dengue and yellow fever viruses.  PLoS Pathogens 7(9): e1002189. doi:10.1371/journal.ppat.1002189.

van den Hurk, A., Horne, K., McGee, C., Hall-Mendelin, S., Day, A., Ryan, P., Ritchie, S.,        Vanlandingham, D.L. & Higgs, S. 2011. Vector competence of Australian mosquitoes for yellow fever virus. American Journal of Tropical Medicine and Hygiene. 85: 446-451.

Fros, J.J., Liu, W.J., Prow, N.A., Geertsema, C., Ligtenberg, M., Vanlandingham, D.L., Schnettler, E., Vlak, J.M., Khromykh, A.A., Pijlman, G.P.  2010. Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling. Journal of Virology. 84:10877-10887.

Skalsky, R.L., Vanlandingham, D.L., Scholle, F., Higgs, S., Cullen, B.R. 2010. Identification of microRNAs expressed in two mosquito vectors, Aedes albopictus and Culex quinquefasciatus.
 BMC Genomics 11:119.

Tsetsarkin, K., McGee, C., Volk, S., Vanlandingham, D.L, Weaver, S., Higgs, S. 2009. Epistatic roles of E2 glycoprotein mutations in adaptation of chikungunya virus to Aedes albopictus and Ae. aegypti mosquitoes. PloS.ONE 31:e6835.

Vanlandingham, D.L., McGee, C.E., Klingler, K, Galbraith, S.A., Barrett, A.D.T., Higgs, S. 2008. Comparison of oral infectious dose of West Nile virus isolates representing three distinct genotypes in Culex pipiens quinquefasciatus.  American Journal of Tropical Medicine and Hygiene. 79:951-954.

Tsetsarkin, K.A., Vanlandingham, D.L., McGee, C.E., Higgs, S. 2007. A single mutation in Chikungunya virus effects vector specificity and epidemic potential. PLoS. 7;3(12):e201.

Vanlandingham, D.L., McGee, C.E., Klingler, K, Higgs, S. 2007. Relative susceptibilities of South Texas mosquitoes to infection with West Nile Virus. American Journal of Tropical Medicine and Hygiene. 77 :925-928.

Tsetsarkin, K.A., Higgs, S., McGee, C.E., de Lamballerie, X., Charrel, R.N., Vanlandingham, D.L. 2006. Infectious clones of Chikungunya virus (La Reunion isolate) for vector competence studies. Vector-borne and Zoonotic Diseases. 4: 325-337.

Vanlandingham, D.L., Tsetsarkin, K., Klingler, K.A., Hong, C., McElroy, K.L., Lehane, M.J., Higgs, S. 2006. Determinants of vector specificity of O’nyong nyong and Chikungunya viruses in Anopheles and Aedes mosquitoes. American Journal of Tropical Medicine and Hygiene. 74: 663-669.

Abraham, E.G., Pinto, S., Ghonsh, A., Vanlandingham, D.L., Budd, A., Higgs, S., Kafatos, F.C.,   Jacobs-Lorena, M., Michel, K. 2005. An immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites. Proceedings of the National Academy of Science. 102: 16327-16332.

Vanlandingham, D.L., Tsetsarkin, K., Hong, C., Klingler, K., McElroy, K.L., Lehane, M.J., Higgs, S. 2005. Development and characterization of a double subgenomic chikungunya virus infectious clone to express heterologous genes in Aedes aegypti mosquitoes. Insect Biochemistry and Molecular Biology 35: 1162-1170.

Vanlandingham, D.L., Hong, C., Tsetsarkin, K., McElroy, K.L., Powers, A.M., Lehane, M.J., Higgs, S. 2005. Differential infectivities of Chikungunya and O’nyong-nyong virus isolates in An. gambiae and Aedes aegypti mosquitoes. American Journal of Tropical Medicine and Hygiene. 72: 616-621.

Vanlandingham, D.L., Schneider, B.S., Klingler, K., Fair, J., Beasley, D., Huang, J., Hamilton, P., Higgs, S. 2004. Real-time reverse transcriptase-polymerase chain reaction quantification of West Nile virus transmitted by Cx. pipiens quinquefasciatus. American Journal of Tropical Medicine and Hygiene. 71: 120-123.

Attardo, G.M., Higgs, S., Klingler, K.A., Vanlandingham, D.L., Raikhel, A.S. 2003. RNA interference-mediated knockdown of a GATA factor reveals a link to anautogeny in the mosquito Aedes aegypti. Proceedings of the National Academy of Science. 100: 13374-13379.

Vanlandingham, D.L., Davis, B.S., Lvov, D.K., Samokhvalov, E., Lvov, S.D., Black, W.C., Higgs, S., Beaty, B.J. 2002. Molecular characterization of California serogroup viruses isolated in Russia. American Journal of Tropical Medicine and Hygiene. 67: 306-309.