Charan K. Ganta
BVSc & AH 2001, ANGR Agricultural University, India
PhD 2006, Kansas State University
Post-doctoral Fellow 2007, Kansas State University
Diplomate 2011, American College of Veterinary Pathologists
Anatomic Pathology & Stem Cell and Exosome Biotechnology
Stem Cell and Exosome Biotechnolgy Laboratory
The primary focus of our laboratory is to understand the therapeutic applications of platelet rich plasma, mesenchymal stem cells and exosomes for various inflammatory diseases in animal models of disease with animal and human health implications. Specific goals include.
- Fetal bovine serum alternatives for mesenchymal stem cell cultures
- Immunomodulatory properties of mesenchymal stem cell derived exosomes to micro-environmental alterations
- Therapeutic intervention of inflammatory diseases using PRP, mesenchymal stem cells and exosomes (clinical collaborations)
I provide pathology service to clinicians. In addition, I also provide comparative pathology services to investigators within the college and university, as well as similar services to national and international investigators.
AP711: Stem Cells and Comparative Biomedicine
DMP 785: Diagnostic pathology clinical rotation
Ganta CK, Blecha F, Ganta RR, Helwig BG, Parimi S, Lu N, Fels RJ, Musch TI and Kenney MJ. Hyperthermia-enhanced splenic cytokine gene expression is mediated by the sympathetic nervous system. Physiol Genomics19: 175-183, 2004.
Ganta CK, Lu N, Helwig BG, Blecha F, Ganta RR, Zheng L, Ross CR, Musch TI, Fels RJ and Kenney MJ. Central angiotensin II-enhanced splenic cytokine gene expression is mediated by the sympathetic nervous system. Am J Physiol Heart Circ Physiol 289: H1683-H1691, 2005.
Ganta CK, Helwig BG, Blecha F, Ganta RR, Cober R, Parimi S, Musch TI, Fels RJ and Kenney MJ. Hypothermia-enhanced splenic cytokine gene expression is independent of the sympathetic nervous system. Am J Physiol Regul Integr Comp Physiol 291: R558-R565, 2006.
Ganta CK. Central Activation of Sympathetic Neural Circuits Alters Splenic Cytokine Gene Expression. 2006. K-state Research Exchange.
Ganta C, Shi A, Battina SK, Pyle M, Rana S, Hua HD, Tamura M and Troyer DL. Combination of nanogel polyethylene glycol-polyethylenimine and 6-(hydroxymethyl)-1,4-anthracenedione as an anticancer nanomedicine. J Nanosci Nanotechnol. 2008 May;8(5):2334-40.
Perchellet EM, Perchellet JP, Ganta CK, Troyer DL, Shi A, and Hua D. Synthesis, molecular targets, and antitumor activities of substituted tetrahydro-1-oxopyrano[4,3-b]benzopyrans and nanogels for drug delivery. Anticancer Agents Med Chem.2009 Oct;9(8):864-76
Ganta C, Ayuzawa R, Chiyo D, Pyle M, Rachakatla RS, Andrews G, Weiss ML, Tamura M and Troyer DL. Rat Umbilical Cord Stem Cells Completely Abolish Rat Mammary Carcinomas with No Evidence of Metastasis or Recurrence 100 Days Post-Tumor Cell Inoculation. Cancer Res 2009;69(5):1815–20.
Kenney MJ, Ganta CK. Autonomic Nervous System and Immune System Interactions. Compr Physiol. 2014 Jul;4(3):1177-200.
Basel MT, Narayanan S, Ganta CK, Shreshta TB, Dezhang L, Pyle M, Hill J, Bossmann SH, Yankee T, Troyer DL. Developing a Xenograft Human Tumor Model in Immunocompetent Mice. Cancer Letters 2018.