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College of Veterinary Medicine

Anatomy & Physiology
College of Veterinary Medicine
Kansas State University

1620 Denison Avenue
228 Coles Hall
Manhattan, KS 66506-5802

Phone: 785-532-5666
Fax: 785-532-4557



Dr. Lin teaches an online course in Physiologically Based Pharmacokinetic Modeling (AP 873) for graduate students every Spring semester. This course is also available as continuing education for scientists in the pharmaceutical industry and governmental agencies, as well as for other non-traditional students through K-State Global Campus.


Register this course

Students can enroll in this course through KSIS or K-State Global Campus. On-campus students should select session “AP 873-A”. Distance students should select session “AP 873-ZA”. Individuals not enrolled at KSU can enroll in this course as “Nondegree-seeking Graduate Students”. Click here for detailed instructions.

Course description

This modeling course is designed for students with an interest in computational toxicology and pharmacology. Development of physiologically based pharmacokinetic (PBPK) models for environmental chemicals, drugs, and nanomaterials in laboratory animals, food-producing animals, companion animals, and/or humans will be introduced. Applications of PBPK models in food safety, toxicology, risk assessment, and pharmaceutical industry will be discussed. This course will cover theory, application software, experimental design, model development, optimization, validation, evaluation, and extrapolation. The expected outcome is that the student will have PBPK modeling knowledge and skills to develop a PBPK model with some mentoring from an experienced PBPK modeler. Course objectives: (1) To provide the student with working knowledge of physiologically based pharmacokinetic models and their applications in toxicology; (2) To provide students with the technical ability to develop PBPK models for use in their research and careers. The format will include both lectures and hands-on computer lab exercises. Each week the student is expected to: (1) Read any assigned textbook chapters, articles, and/or supplementary materials, (2) Listen/watch any posted lectures/podcasts, (3) Do any lab assignments, which must be submitted by Sunday of that week. Each student is expected to work on a PBPK modeling project with the instructor throughout the semester and complete the project by the end of the course. Course evaluation: Grades will be determined from computer lab simulation exercises/assignments (25%), participation in online discussions (25%), and two project presentations which demonstrate the development of a PBPK model and the application of the PBPK model in toxicology (50%).

Click here for the course syllabus for 2017 Spring semester (new content will be added to the 2018 Spring syllabus)

Guest lecturers

Dr. Jeffrey W. Fisher, Research Toxicologist, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, AR 72079


Dr. Raymond S. H. Yang, Professor Emeritus, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80526