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College of Veterinary Medicine

Megan C. Niederwerder

megan

Assistant Professor

B.S. Northwest Missouri State University
D.V.M. Kansas State University
Ph.D. Kansas State University
Office: L-227 Mosier Hall
Phone: 785-532-4663
Email: mniederwerder@vet.k-state.edu

Teaching

Dr. Niederwerder serves as Course Coordinator and Instructor in the DMP822 Veterinary Virology course (3 credit hours) for second year veterinary professional students and graduate students. She is responsible for almost 40% of the lectures in the course and covers viral diseases in swine, equine, avian, bovine and canine species. Dr. Niederwerder also serves as a mentor to veterinary, graduate and undergraduate students. 

Research

Dr. Niederwerder’s research investigates control strategies for endemic and foreign animal diseases of swine. She is internationally recognized for her expertise in two primary areas of research, including 1) the role of the gut microbiome on outcome following viral respiratory infections and 2) the risk and mitigation of foreign animal disease introduction and transmission through feed and feed ingredients. Projects have focused primarily on African swine fever virus (ASFV) in feed and respiratory disease following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2). Additional research has been conducted on porcine epidemic diarrhea virus (PEDV), classical swine fever virus (CSFV), and pseudorabies virus (PRV).    

Peer-Reviewed Publications (*Indicates corresponding author) 

  1. *Patterson, G., M.C. Niederwerder, S.A. Dee. 2019. Risks to animal health associated with imported feed ingredients. J Am Vet Med Assoc. 254(7): 790-791. DOI: 10.2460/javma.254.7.790.

  2. *Niederwerder, M.C., A.M.M. Stoian, R.R.R. Rowland, S.S. Dritz, V. Petrovan, L.A. Constance, J.T. Gebhardt, M. Olcha, C.K. Jones, J.C. Woodworth, Y. Fang, J. Liang, T.J. Hefley. 2019. Infectious dose of African swine fever virus when consumed naturally in liquid or feed. Emerging Infectious Diseases. 25(5): 891-897. https://doi.org/10.3201/eid2505.181495.

  3. *Niederwerder, M.C. 2018. Fecal microbiota transplantation as a tool to treat and reduce susceptibility to disease in animals. Invited review. Veterinary Immunology and Immunopathology. 206:65-72. DOI: 10.1016/j.vetimm.2018.11.002.

  4. Guo, R., P. Shang, C.A. Carrillo, Z. Sun, Y.S. Lakshmanappa, X. Yan, G.J. Renukaradhya, J. McGill, C.J. Jaing, M.C. Niederwerder, R.R.R. Rowland,*Y. Fang. 2018. Double-stranded viral RNA persists in vitro and in vivo during prolonged infection of porcine reproductive and respiratory syndrome virus. Virology. 524: 78-89. doi: 10.1016/j.virol.2018.08.006.

  5. *Niederwerder, M.C., L.A. Constance, R.R.R. Rowland, W. Abbas, S.C. Fernando, M.L. Potter, M.A. Sheahan, T.E. Burkey, R.A. Hesse, A.G. Cino-Ozuna. 2018. Fecal Microbiota Transplantation is Associated with Reduced Morbidity and Mortality in Porcine Circovirus Associated Disease. Front Microbiol. 9:1631. doi: 10.3389/fmicb.2018.01631.

  6. Gebhardt, J.T., R.C. Cochrane, J.C. Woodworth, C.K. Jones, M.C. Niederwerder, M.B. Muckey, C.R. Stark, M.D. Tokach, J.M. DeRouchey, R.D. Goodband, J. Bai, P.C. Gauger, Q. Chen, J. Zhang, R.G. Main, *S.S. Dritz. 2018. Evaluation of the effects of flushing feed manufacturing equipment with chemically treated rice hulls on porcine epidemic diarrhea virus (PEDV) cross contamination during feed manufacturing. J Anim Sci. 96(10):4149-4158. https://doi.org/10.1093/jas/sky295.

  7. *Dee, S.A., F.V. Bauermann, M.C. Niederwerder, A. Singrey, T. Clement, M. de Lima, C. Long, G. Patterson, M.A. Sheahan, A.M.M. Stoian, V. Petrovan, C.K. Jones, J. De Jong, J. Ji, G.D. Spronk, L. Minion, J. Christopher-Hennings, J.J. Zimmerman, R.R.R. Rowland, E. Nelson, P. Sundberg, and D.G. Diel. 2018. Survival of viral pathogens in animal feed ingredients under transboundary shipment models. PLoS One. 13(3): e0194509. doi: 10.1371/journal.pone.0194509.  

  8. *Niederwerder, M.C. and R.A. Hesse. 2018. Swine enteric coronavirus disease: A review of 4 years with porcine epidemic diarrhoea virus and porcine deltacoronavirus in the United States and Canada. Transbound Emerg Dis. 65(3):660-675. doi: 10.1111/tbed.12823.   

  9. Dunkelberger, J.R., N.V.L. Serão, Z. Weng, E.H. Waide, M.C. Niederwerder, M.A. Kerrigan, J.K. Lunney, R.R.R. Rowland, *J.C.M. Dekkers. 2017. Genomic regions associated with host response to porcine reproductive and respiratory syndrome vaccination and co-infection in nursery pigs. BMC Genomics. 18(1):865. doi: 10.1186/s12864-017-4182-8. 

  10. Ober, R.A., J.B. Thissen, C.J. Jaing, A.G. Cino-Ozuna, R.R.R. Rowland, and *M.C. Niederwerder. 2017. Increased microbiome diversity at the time of infection is associated with improved growth rates of pigs after co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2). Vet Microbiol. 208: 203-211. doi: 10.1016/j.vetmic.2017.06.023.

  11. *Niederwerder, M.C. 2017. Invited review. Role of the microbiome in swine respiratory disease. Vet Microbiol. 209: 97-106. doi: 10.1016/j.vetmic.2017.02.017.

  12. Dunkelberger, J.R., N.V. Serão, M.C. Niederwerder, M.A. Kerrigan, J.K. Lunney, R.R. Rowland, and *J.C. Dekkers. 2017. Effect of a major quantitative trait locus for porcine reproductive and respiratory syndrome (PRRS) resistance on response to coinfection with PRRS virus and porcine circovirus type 2b (PCV2b) in commercial pigs, with or without prior vaccination for PRRS. J Anim Sci. 95(2): 584-598. doi: 10.2527/jas.2016.1071.

  13. *Niederwerder, M.C., and R.R.R. Rowland. 2017. Is there a risk for introducing porcine reproductive and respiratory syndrome virus (PRRSV) through the legal importation of pork? Food Environ Virol. 9(1): 1-13. doi: 10.1007/s12560-016-9259-z.

  14. *Niederwerder, M.C., J.C. Nietfeld, J. Bai, L. Peddireddi, B. Breazeale, J. Anderson, M.A. Kerrigan, B. An, R.D. Oberst, K. Crawford, K.M. Lager, D.M. Madson, R.R.R. Rowland, G.A. Anderson, and R.A. Hesse. 2016. Tissue localization, shedding, virus carriage, antibody response and aerosol transmission of Porcine epidemic diarrhea virus (PEDV) following inoculation of 4-week-old feeder pigs. J Vet Diagn Invest. 28(6): 671-678.

  15. *Niederwerder, M.C., C.J. Jaing, J.B. Thissen, A.G. Cino-Ozuna, K.S. McLoughlin, and R.R. Rowland. 2016. Microbiome associations in pigs with the best and worst clinical outcomes following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2). Vet Microbiol. 188: 1-11. doi: 10.1016/j.vetmic.2016.03.008.

  16. *Niederwerder, M.C., B. Bawa, N.V. Serão, B.R. Trible, M.A. Kerrigan, J.K. Lunney, J.C. Dekkers, and R.R. Rowland. 2015. Vaccination with a porcine reproductive and respiratory syndrome (PRRS) modified live virus vaccine followed by challenge with PRRS virus and porcine circovirus type 2 (PCV2) protects against PRRS but enhances PCV2 replication and pathogenesis compared to results for nonvaccinated cochallenged controls. Clin Vaccine Immunol. 22(12): 1244-54. doi: 10.1128/CVI.00434-15.

  17. *Jaing, C.J., J.B. Thissen, S.N. Gardner, K.S. McLoughlin, P.J. Hullinger, N.A. Monday, M.C. Niederwerder, and R.R. Rowland. 2015. Application of a pathogen microarray for the analysis of viruses and bacteria in clinical diagnostic samples from pigs. J Vet Diagn Invest. 27(3): 313-325. doi: 10.1177/1040638715578484.

  18. *Niederwerder, M.C., I.H. Stalis, G.A. Campbell, and K.A. Backues. 2013. Gastric pneumatosis with associated eosinophilic gastritis in four black and white ruffed lemurs (Varecia variegata variegata). J Zoo Wildl Med. 44(1): 79-86.

  19. *Niederwerder, M.C., S. Crochik, M.C. Rochat, and K.A. Backues. 2011. Clinical Challenge: Diskospondylitis of L6-L7 in a snow leopard cub (Uncia uncia). J Zoo Wildl Med. 42(4): 774-777.