Jodi L. McGill
Assistant Professor of Immunology
B.S. in Microbiology, 2005, Iowa State University
M.S. in Pathology, 2007, University of Iowa
Ph.D in Immunology, 2010, University of Iowa
My laboratory focuses on the innate and adaptive immune response to respiratory pathogens in cattle.
One of my main areas of interest is the role of the immune system in defense against bovine respiratory disease complex (BRDC). BRDC is a multifactorial disease complex that is initiated by a primary viral infection, followed by secondary bacterial pneumonia. My research focuses on the role of innate immune populations, in particular γδ T cells and alveolar macrophages, in the response to infection with pathogens of BRDC including bovine respiratory syncytial virus, Mannheimia haemolytica and Pasturella multocida. We also focus on the development of novel vaccine strategies, including polyanhydride nanoparticle-based vaccines, to protect young animals against pathogens of BRDC.
My other main area of interest is the immune response to Mycobacterium bovis infection in cattle. I am particularly interested in the antigen-specific γδ T cell response and the role it plays in vivo at the site of M. bovis infection. I am also focused on defining the antigen and costimulation requirements for efficient γδ T cell activation during M. bovis infection and applying this knowledge to a more comprehensive vaccination strategy.
I coordinate and teach DMP 862, Applied Immunology of Domestic Animals. This course is a 2 credit hour course for clinical scientists and mid-program Ph.D students. It is a paper-based course designed to provide updated information on advances in innate and adaptive immune responses relevant to the diagnosis, prevention and treatment of diseases of domestic animals.
Nonnecke, B.J.; McGill, J.L.; Ridpath, J.F.; Sacco, R.E.; Lippolis, J.D.; Reinhardt, T.A. 2014. Acute phase response elicited by experimental bovine diarrhea virus (BVDV) infection is associated with decreased vitamin D and E status of vitamin-replete preruminant calves. J. Dairy Sci. 97: 5566-5579.
McGill, J.; Sacco, R.E.; Baldwin, C.L.; Telfer, J.C.; Palmer, M.V.; Waters, W.R. 2014. Specific recognition of mycobacterial protein and peptide antigens by gamma-delta T cell subsets following infection with virulent Mycobacterium bovis. J Immunol. 192: 2756-69.
Smirnova, N.P.; Webb, B.T.; McGill, J.L.; Schaut, R.G.; Bielefeldt-Ohmann, H.B.; Van Campen, H.; Sacco, R.E.; Hansen, T.R. 2014. Induction of interferon-gamma response during establishment of fetal persistent infection with bovine viral diarrhea virus. Virus Res. 183: 95-106.
Baldwin, C.L.; Hsu, H.; Chen, C.; Palmer, M.; McGill, J.; Waters, W.R.; Telfer, J.C. 2014. The role of bovine gamma-delta T cells and their WC1 co-receptor in response to bacterial pathogens and promoting vaccine efficacy: A model for cattle and humans. Vet Immunol Immunopathol. 159: 144-55.
McGill, J.; Sacco, R.E.; Baldwin, C.L.; Telfer, J.C.; Palmer, M.V.; Waters, W.R. 2014. The role of gamma-delta T cells in immunity to Mycobacterium bovis infection in cattle. Vet Immunol Immunopathol. 159: 133-43.
Waters, W.R.; Maggioli, M.R.; McGill, J.L.; Lyashchenko, K.; Palmer, M.V. 2014. Relevance of bovine tuberculosis research to the understanding of human disease: Historical perspectives, approaches, and immunologic mechanisms. Vet Immunol Immunopathol. 159: 113-32.
Derscheid, R.J.; van Geelen, A.; McGill, J.L.; Gallup, J.M.; Cihlar, T.; Sacco, R.E.; Ackermann, M.R. 2013. Human respiratory syncytial virus Memphis 37 grown in HEp-2 cells causes more severe disease in lambs than virus grown in Vero cells. Viruses. 5: 2881-97.
Sacco, R.E.; McGill, J.L.; Pillatzki, A.E.; Palmer, M.V.; Ackermann, M.R. 2014. Respiratory syncytial virus infection in cattle. Vet. Pathol. 51: 427-436.
McGill, J.; Nonnecke, B.J.; Lippolis, J.D.; Reinhardt, T.J.; Sacco, R.E. 2013. Differential chemokine and cytokine production by neonatal bovine γδ T cell subsets in response to viral toll-like receptor agonists and in vivo BRSV infection. Immunology. 139: 227-244.
Sacco, R.E.; McGill, J.; Palmer, M.V.; Lippolis, J.D.; Reinhardt, T.J.; Nonnecke, B.J. 2012. Neonatal calf infection with respiratory syncytial virus: drawing parallels to the disease in human infants. Viruses. 4: 3731-3753.