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Veterinary Health Center

Clinical Trials Office
Phone: 785-532-3046

Veterinary Health Center
1800 Denison Ave.
Manhattan, KS 66506

For appointments or emergencies call:

Small Animal Desk
785-532-4309 fax

Large Animal Desk
785-532-4989 fax


Stem Cell Therapy For Feline CKD


Adipose tissue (fat) derived mesenchymal stromal cells (aMSCs) for treating feline chronic kidney disease: a pilot study  

Purpose and Brief Study Description:

Chronic kidney disease (CKD) in cats is a progressive, degenerative disease that has poor prognosis even in the face of extensive therapeutic intervention. In the last few years, stem cell therapy has shown significant promise in treating chronic diseases. Recent studies have shown that the immunomodulatory properties of stem cells play a critical role in slowing kidney disease progression. This study proposes the use of adipose tissue derived stromal and stem cells population, called SVF, to treat cats with CKD.

Inclusion Criteria: --ENROLLMENT CLOSED--

Cats with chronic kidney disease (IRIS stage 2, 3 or 4)

Cats must be good candidates for surgery to collect a small amount of abdominal fat

Exclusion Criteria:

Cats will be excluded from the study if any of the following conditions are identified at initial evaluation: hyperthyroidism, diabetes mellitus, neoplasia, systolic hypertension (> 180 mmHg), and urinary tract infections.

What does enrollment into this trial involve?

Enrolled cats will be anesthetized for surgery to remove a small amount of falciform fat (abdominal fat). While the cat is recovering from surgery, the fat will be processed for SVF isolation.

The stem cells will be administered via IV injection on study day 0, 15, 30. All cats will be re-evaluated at 14 day intervals post SVF injection (i.e., the day prior to the next SVF injection) by physical exam, blood work for CBC, profile, and urinalysis and glomerular filtration rate (GFR). Similar evaluations will be performed for each cat on days 30, 45, 60 and 120. Further follow-up evaluations may be scheduled to monitor clinical progress at 2-3 month interval for a total period of 1 year post SVF injection.

Client Compensation:

Once enrolled, all costs associated with surgery for fat removal, hospitalization, follow-up visits along with laboratory testing will be paid by study funds.


Contact Information:

For more information, please contact Misty Bear, Clinical Trials Coordinator:

E-mail: ClinicalTrials@vet.k-state.edu, phone: (785)532-3046