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College of Veterinary Medicine

Peer Reviewed Articles and Monographs

Miller D, Rathbun T, Boyle D, Troyer D, Davis D.L.: Confocal Imaging of Trans-epithelial Trafficking by Immune and Umbilical Cord Stem Cells in the Neonatal Porcine Intestine. Anatomia Histologica Embryologica, doi:10.1111/j.14390264.2012.01157.x, Epub ahead of print, 2012

Wang H, Shrestha T, Basel M, Dani R, Seo G-M, Balivada S, Pyle M, Prock H, Koper O, Thapa P, Moore D, Li P, Chikan V, Troyer D, Bossmann S: Magnetic Fe/Fe304 nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages. Beilstein Journal of Nanotechnology 3:444-455, 2012.

Basel M, Balivada S, Beck A, Kerrigan M, Pyle M, Dekkers J, Wyatt C, Rowland R, Anderson D, Bossmann S, Troyer D: Human xenografts are not rejected in a naturally occurring immunodeficient porcine line: a human tumor model in pigs. BioResearch Open Access, Epub, 2:DOI. 10.1089/biores.2012.9902, 2012; PMID: 23016149; PMCID: PMC3388369

Shrestha T, Seo G, Basel M, Kalita M, Wang H, Villanueva D, Pyle M, Troyer D, Bossmann S: Stem cell-based photodynamic therapy: 1. In-vitro studies. Photochem. Photobiol. Chem. DOI: 10.1039/c2pp05417e, 2012.

Wang L, Liu Z, Balivada S, Shreshtha T, Bossmann S, Pyle M, Pappan L, Shi J, Troyer D: IL-1beta and TGF beta cooperate to induce neurosphere formation and increase tumorigenicity of adherent LN-229 glioma cells. Stem Cell Research and Therapy, 35, 2012; PMID: 22330721.

Basel M, Balivada S, Wang H, Shrestha T, Seo G, Pyle M, Abayaweera G, Daini R, Koper O, Tamura M, Chikan V, Bossmann S, Troyer D: Cell-delivered magnetic nanoparticles casuses hyperthermia-mediated increased survival in a murine pancreatic cancer model. International. Journal of Nanomedicine, 7:297-306, 2012; PMID: 22287840; PMCID: PMC3265998

Basel M, Balivada S, Shrestha T, Seo G, Pyle M, Bossmann S, Troyer D: A cell-delivered and activated SN38-dextran prodrug increases survival in a murine disseminated pancreatic cancer model. Small, 8(6):913-920, 2012; PMID: 22238072; PMCID pending

Tamura M, Kawabata A, Ohta N, Uppalapati K, Becker K, Troyer D: Wharton's jelly stem cells as agents for cancer therapy. The Open Tissue Engineering and Regenerative Medicine Journal. 4:39-47, 2011

Uppalapati D, Ohta N, Zhang Y, Kawabata A, Pyle MP, Becker KG, Troyer D, Tamura M: Identification and characterization of unique tumoricidal genes in rat umbilical cord matrix stem cells. Mol Pharm. 8:1549-1558, 2011; PMID: 21851062 ; NIHMS326348; PCMID: PMC3202613.
Seo G-M, Rachakatla R, Balivada S, Pyle M, Shrestha T, Wang H, Tamura M, Bossmann S, Troyer DL: A self-contained enzyme activating prodrug cytotherapy for preclinical melanoma. Mol Biol Reports 39(1):157-165, 2011; NIHMS304695; PMID: 21567204; PCMID: PMC 3222711.

Tamura M, Troyer D, Maurya D, Rachakatla R: Cytokines and Lung Cancer, In: Cytokines, pp 173-187, Editors Preedy VR and Hunter RJ, CRC Press, 2011

Basel MT, Shrestha T, Troyer D, Bossmann SH: Protease-sensitive, polymer-caged liposomes: a method for making highly targeted liposomes using triggered release. ACS Nano, 5(3):2162-2175, 2011, PMID: 21314184; PCMID pending

Rachakatla R, Balivada S, Seo G, Myers C, Wang H, Samarakoon T, Dani R, Pyle M, Kroh F, Walker B, Leaym X, Koper O, Chikan V, Bossmann S, Tamura M, Troyer D: Attenuation of mouse melanoma by A/C magnetic field after delivery of bi-magnetic nanoparticles by neural progenitor cells. ACS Nano 4(12):7093-7104, 2010, PubMed #21058696, NIHMSID#251431, Publ.ID:nn100870z; PMCID# PMC3011034.

Balivada S, Rahcakatla R, Wang H, Samarakoon T, Dani R, Pyle M, Kroh F, Walker B, Leaym, Koper O, Tamura M, Chikan V, Bossmann S, Troyer D: A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles: a mouse study. BMC Cancer, 10:119, 2010, PMCID: PMC2859385.

Doi C, Maurya D, Pyle M, Troyer D, Tamura M: Cytotherapy with naïve rat umbilical cord matrix stem cells significantly attenuates growth of murine pancreatic cancer cells and increases mouse survival in syngeneic mice. Cytotherapy, 12:408-417, 2010. NIHMSID # 210621, PMCID: PMC2896419.

Matsuzuka T, Rachakatla R, Chiyo D, Maurya D, Ohta N, Kawabata A, Pyle M, Pickel L, Reischman J, Marini F, Troyer D, Tamura M: Human umbilical cord matrx-derived stem cells expressing interferon beta gene significantly attenuate bronchioloalveolar carcinoma xenografts in SCID mice. Lung Cancer 70:28-36, 2010. PMID: 20138387; NIHMS171227.

Doi C, Egashira N, Ayuzawa R, Kawabata A, Maurya D, Ohta N, Upparapati L, ayuzawa R, Pickel L, Isayama Y, Troyer D, Takekoshi S, Tamura M: Angiotensin II type 2receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafs in syngeneic mice. BMC Cancer, Feb 24;10(1):67, 2010, PMCID: PMC2846883.

Maurya D, Doi C, Pyle M, Kawabata A, Troyer D, Tamura M: Therapy with un-engineered naïve rat umbilical cord matrix stem cells markedly inhibits growth of murine lung adenocarcioma. BMC Cancer 10:590, 2010.

Lutjemeier B, Troyer DL, Weiss M: Wharton's jelly as a source of mesenchymal stromal cells. In: Perinatal Stem Cells, Editors Cetrulo C and Cetrulo K, Wiley-Blackwell, 2009.

Ganta C, Chiyo D, Ayuzawa R, Rachakatla R, Pyle M, Andrews G, Weiss M, Tamura M, Troyer D: Rat umbilical cord stem cells completely abolish rat mammary carcinomas with no evidence of metastasis or recurrence 100 days post-tumor cell inoculation. Cancer Res 69(5): 1815-1820, 2009, PMID: 19244122.

Ayuzawa R, Doi C, Rachakatla R, Pyle M, Maurya D, Troyer D, Tamura M: Naïve human umbilical cord matrix derived stem cells significantly attenuate growth of human cancer cells in vitro and in vivo. Cancer Lett, 280:31-37, 2009, PMID: 19285791, NIHMSID #:122061.

Rachakatla R, Troyer D: Wharton's jelly stromal cells as potential delivery vehicles for cancer therapeutics. Future Oncology 5(8):1237-1244, 2009.

Perchellet EM, Perchellet J-P, Ganta C, Troyer D, Shi A, Hua D: Anti-cancer activities of substituted 1-Oxopyranol [4,3][1] benzopyrans and nanogels for drug delivery. Anti-Cancer Agents in Medicinal Chemistry, 9:864-876, 2009.

Rachakatla R, Pyle M, Ayuzawa R, Edwards S, Marini F, Weiss M, Tamura M, Troyer D: Combination treatment of human umbilical cord matrix stem cell-based interferon-beta gene therapy and 5-fluorouracil reduces growth of metastatic human breast cancer in SCID mouse lungs. Cancer Investigation 26:662-670, 2008, PMID: 18608205, NIHMSID #: 220578.

Troyer D, Weiss M: Wharton's Jelly-derived cells are a primitive stromal cell population. Stem Cells 26(3):591-599, 2008.

Ganta C, Aibin S, Battina S, Pyle M, Rana S, Hua D, Tamura M, Troyer D: Combination of nanogel polyethylene glycol-polyethyleneimine and 6 (hydroxymethyl)-1,4-anthracenedione as an anticancer nanomedicine. Nanoscience and Nanotechnology, 8(5):2334-2340, NIHMS53150, PMCID: PMC2556214, 200

Seshareddy K, Troyer D, Weiss M: Method to isolate mesenchymal-like cells from Wharton's jelly of umbilical cord. Methods in Cell Biology; 86:101-19, 2008. PMID: 18442646

Tani T, AyuzawaR, Takagi T, Kanehira T, Maurya D, Troyer D, Tamura T: Angiotensin II bi-directionally regulates cyclooxygenase-2 expression in intestinal epithelial cells. Mol Cell Biochem. 315:185-193, 2008. PMID: 18543083, NIHMSID#: 220271.

Weiss M, Troyer D: Stem cells in the umbilical cord. Stem Cell Reviews 2(2):155-162, 2007.

Rachakatla R, Marini F, Weiss M, Tamura M, Troyer D: Development of human umbilical cord matrix stem cell-based gene therapy for experimental lung tumors. Cancer Gene Therapy 14:828-835,2007, PMID: 17599089.

Mark L. Weiss and Deryl L. Troyer: Stem Cells in the Umbilical Cord. Stem Cell Reviews 2(2), 2006 in press.

Carlin C, Davis D, Weiss M, Schultz B, Troyer D: Expression of Early transcription factors, Oct-4, Sox-2 and Nanog by porcine umbilical cord (PUC) matrix cells. Reproductive Biology and Endocrinology 4(1):8, Open Access, 2006.

Weiss ML, Medicetty S, Bledsoe AR, Rachakatla RS, Coi M, Merchav S, Luo Y, Rao MS,Velagaleti G, Troyer D: Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease. Stem Cells (Epub ahead of print), 2005.

Cai J, Weiss M, Rao M: In search of 'stemness'. Exper Hematol. 32(7):585-98, 2004.

Medicetty S, Fahrenholtz C, Bledsoe A, Troyer D, Mitchell K, Weiss M: Transplantation of pig stem cells into rat brain: Proliferation during the first 8 weeks. Experimental Neurology 190(1):32-44, 2004.

Mitchell K, Weiss M, Medicetty S, Mitchell B, Martin P, Davis D, Morales L, Helwig B, Beerenstrauch M, Abou-Easa K, Hildreth T, Troyer D: Matrix cells from Wharton's jelly form neurons and glia, Stem Cells 21(1):61-70, 2003.

Weiss ML, Hix JE, Medicetty S, Mitchell KE, Grieger D, Troyer DL: Xenotransplantation of porcine umbilical cord matrix cells into the rat. Experimental Neurology 182(2):288-299, 2003.

Troyer DL, Weiss ML, Mitchell KE, Martin PL, Davis DL: Incorporation of bovine bone marrow stromal cells into porcine fetal tissues after xenotransplantation. Anatomia Histologia Embryologia 32(2):98-101, 2003.

Martin PL, Davis D, Weiss M, Grieger D, Abou-Easa K, Troyer D: Xenotransplantation of bovine bone marrow stromal cells into fetal pigs: incorporation into skeletal muscle. Animal Biotechnology 12(2):183-191, 2001.


Email Mark Weiss, Weiss@vet.k-state.edu, new Wharton's jelly papers to be included.