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College of Veterinary Medicine

Wenjun Ma

 Associate Professor

BVSc 1996, Northeast Agricultural University, Harbin, China
MVSc 1999, Chinese Academy of Agricultural Science, Beijing, China
PhD 2003, Justus-Liebig-University, Giessen, Germany

Phone: 785-532-4337
Fax: 785-532-4039
Email: wma@vet.k-state.edu

Research

Ma’s laboratory is interested in viral diseases of animals, with an emphasis on emerging zoonotic viral infections. His current research focuses on understanding mechanisms of pathogenesis and developing vaccines and/or antivirals for different viral pathogens, such as Influenza virus, Rift Valley Fever virus, porcine circovirus 3, African swine fever virus and other viral infections in livestock and poultry. He is also interested in development of rapid detection systems for different viral diseases. Ma’s laboratory research has been supported by funds from National Institute of Health, Department of Homeland Security, Kansas Bioscience Authority, National Pork Board and industry partners. He has published more than 60 papers in peer-reviewed prestigious journals, and has been invited to give presentations by national and international universities, research institutes and conferences.

Teaching

My primary teaching role is to further develop graduate student training in virology. I participate in the teaching of one graduate course (DMP-910, Pathogenic Mechanisms of viruses, 3 credits) with other faculty.

Selected publications (*corresponding author)

Xia C, Wolf JJ, Vijayan M, Studstill CJ, Ma W, Hahm B. Casein kinase 1α mediates degradation of receptors for type I and type II interferons caused by hemagglutinin of influenza A virus. J Virol. 2018 Jan 17. pii: JVI.00006-18. [Epub ahead of print]

Ma J, Lee J, Liu H, Mena I, Davis S, Sunwoo S, Lang Y, Duff M, Morozov I, Li Y, Yang J, Garcia-Sastre A, Richt J, Ma W*. Newcastle Disease Virus-Based H5 Influenza Vaccine Protects Chickens from Lethal Challenge with a highly pathogenic H5N2 Avian Influenza Virus. npjVaccines, 2017. 2:33. PMID: 29263888.

Wang D and Ma W*. Visualization of IAV Genomes at the Single-Cell Level. Trends Microbiol. 2017 25(10):781-782. PMID: 28843669.

Wang X, Chen S, Wang D, Zha X, Zheng S, Qin T, Ma W*, Peng D, Liu X. Synergistic effect of PB2 283M and 526R contributes to enhanced pathogenicity of H5N8 influenza viruses. Vet Res. 2017. 48(1):67. PMID: 29070059.

Lee J, Henningson J, Ma J, Duff M, Lang Y, Li Y, Li Y, Nagy A, Sunwoo S, Bawa B, Yang J, Bai D, Richt JA, Ma W*. 2017. Effects of PB1-F2 on the pathogenicity of H1N1 swine influenza virus in mice and pigs. J Gen Virol. 2017. 98:31–42. PMID: 28008819.

Yang J, Lee J, Ma J,  Lang Y, Nietfeld J, Li Y, Duff M, Li Y, Yang Y, Liu H, Zhou B, Wentworth D, Richt J, Li Z, Ma W*. 2017. Pathogenicity of modified bat influenza virus with different M genes and its reassortment potential with swine influenza A virus. J Gen Virol. 2017. 98(4):577-584. PMID: 28100299.

Lee J, Hai Yu, Li Y, Ma J, Lang Y, Duff M, Henningson J, Liu Q, Li Y, Nagy A, Bawa B, Li Z, Tong G, Richt J, and Ma W*. 2017. Impacts of different PA-X expression forms on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses. Virology. 2017. 504:25-35. PMID: 28142079.

Lang Y, Henningson J, Jasperson D, Li Y, Lee J, Ma J, Li Y, Cao N, Liu H, Wilson W, Richt J, Ruder M, McVey S, Ma W*. Mouse model for the Rift Valley fever virus MP12 strain infection. Vet Microbiol. 2016, 195:70-77. PMID: 27771072.

Nagy A, Lee J, Mena I, Henningson J, Li Y, Ma J, Duff M, Li Y, Lang Y, Yang J, Abdallah F, Richt J, Ali A, García-Sastre A, Ma W*. 2016. Recombinant Newcastle disease virus expressing H9 HA protects chickens against heterologous avian influenza H9N2 virus challenge. Vaccine. 34(23):2537-45 PMID: 27102817.

Sang Y, Liu Q, Lee J, Ma W*, McVey DS, Blecha F. 2016. Expansion of amphibian intronless interferons revises the paradigm for interferon evolution and functional diversity. Sci Rep. 6:29072. PMID: 27356970.

Wilson WC, Davis AS, Gaudreault NN, Faburay B, Trujillo JD, Shivanna V, Sunwoo SY, Balogh A, Endalew A, Ma W, Drolet BS, Ruder MG, Morozov I, McVey DS, Richt JA. Experimental Infection of Calves by Two Genetically Distinct Strains of Rift Valley Fever Virus. Viruses. 2016, 8(5). PMID: 27223298

Teng Q, Xu D, Shen W, Liu Q, Rong G, Li X, Yan L, Yang J, Chen H, Yu H, Ma W*, Li Z. 2016. A Single Mutation at Position 190 in Hemagglutinin Enhances Binding Affinity for Human Type Sialic Acid Receptor and Replication of H9N2 Avian Influenza Virus in Mice. J Virol. 2016 90(21):9806-9825. PMID: 27558420.  

Faburay B, Wilson WC, Gaudreault NN, Davis AS, Shivanna V, Bawa B, Sunwoo SY, Ma W, Drolet BS, Morozov I, McVey DS, Richt JA. 2016. A Recombinant Rift Valley Fever Virus Glycoprotein Subunit Vaccine Confers Full Protection against Rift Valley Fever Challenge in Sheep. Sci Rep. 6:27719. PMID: 27296136.

Xiao C#, Ma W#, Sun N, Huang L, Li Y, Zeng Z, Wen Y, Zhang Z, Li H, Li Q, Yu Y, Zheng Y, Liu S, Hu P, Zhang X, Qi W, and Liao M. 2016. PB2-588V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza viruses. Sci Rep. 6:19474. PMID: 26782141 (#Equal contribution).

Ma W*, García-Sastre A, Schwemmle M. 2015. Expected and unexpected features of the newly discovered bat influenza A-like viruses. PLoS Pathog. 11(6):e1004819. PMID: 26042416.  

Ran Z, Shen H, Lang Y, Kolb EA, Turan N, Zhu L, Ma J, Bawa B, Liu Q, Liu H, Quast M, Sexton G, Krammer F, Hause BM, Christopher-Hennings J, Nelson EA, Richt J, Li F, Ma W*. 2015. Domestic pigs are susceptible to infection with influenza B viruses. J Virol. 89(9):4818-26. PMID: 25673727. 

Ma J, Shen H, Liu Q, Bawa B, Qi W, Duff M, Lang Y, Lee J, Yu H, Bai J, Tong G, Hesse RA, Richt JA, Ma W*. 2015. Pathogenicity and transmissibility of novel reassortant H3N2 influenza viruses with 2009 pandemic H1N1 genes in pigs. J Virol. 89(5):2831-41. PMID: 25540372.

Zhou B, Ma J, Liu Q, Bawa B, Wang W, Shabman RS, Duff M, Lee J, Lang Y, Cao N, Nagy A, Lin X, Stockwell TB, Richt JA, Wentworth DE, Ma W*. 2014. Characterization of Uncultivable Bat Influenza Virus Using a Replicative Synthetic Virus. PLoS Pathog. 10(10): e1004420. PMID: 25275541.

Ma W*, Liu Q, Qiao C, del Real G, García-Sastre A, Webby RJ, Richt JA. 2014. North American triple reassortant and Eurasian H1N1 swine influenza viruses do not readily reassort to generate a 2009 pandemic H1N1-like virus. mBio. 5(2):e00919-13. PMID: 24618255.

Ma W, Vincent AL, Gramer MR, Brockwell CB, Lager KM, Janke BH, Gauger PC, Patnayak DP, Webby RJ, Richt JA. 2007. Identification of H2N3 Influenza A viruses from swine in the United States. Proc Natl Acad Sci U S A, 104(25): 20949-20954. PMID: 18093945. 

View the complete publication list in the below link:

http://scholar.google.com/citations?user=39rYSEsAAAAJ&hl=en&oi=ao