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College of Veterinary Medicine

Yan-Jang (Scott) Huang, Ph.D.

 ScottResearch Assistant Professor, Arbovirology

PhD, Kansas State University
BS, National Taiwan University

Office: 1041 Pat Roberts Hall
Phone: 785-532-0928
Fax: 785-532-0973
Email: yshuang1985@bri.ksu.edu

Research

My research focuses on characterizing the interactions between mosquito-borne viruses and their vectors and the influence of viral genetics on the virulence, transmission efficiency, and attenuation of different arthropod-borne viruses. The long-term objective of my research is to determine mechanisms that are responsible for the emergence of mosquito-borne viruses in nature. By studying the related mechanisms, it can not only provide the knowledge for the formulation of control strategies for emerging arboviral diseases but also assist the development of safer and immunogenic vaccine candidates. Through collaborative research, I have conducted research on emerging and re-emerging arboviruses such as Zika virus (ZIKV), chikungunya virus (CHIKV), dengue viruses (DENV), yellow fever virus (YFV), and Japanese encephalitis virus (JEV). 

 

Service

I am currently the director of the Molecular Virology and Immunology Core Laboratories at the Biosecurity Research Institute. My role is to coordinate and provide the resources required for the molecular virology and immunology research in the bio-containment facility.

 

Selected Publications

Referred Publications

George J., Valiant W.G., Mattapallil M.J., Walker M., Huang Y.S., Vanlandingham D.L., Misamore J., Greenhouse J., Weiss D.E., Verthelyi D., Higgs S., Andersen H., Lewis M.G., Mattapallil JJ (2017) Prior Exposure to Zika Virus Significantly Enhances Peak Dengue-2 Viremia in Rhesus Macaques Scientific Reports7:10498

Huang Y.S., Lyons A.C., Hsu W.W., Park S.L., Higgs S., Vanlandingham D.L. (2017) Differential outcomes of Zika virus infection in Aedes aegypti orally challenged with infectious blood meals and infectious protein meals. PLoS One 12(8):e0182386

Pardi N., Hogan M.J., Pelc R.S., Muramatsu H., Andersen H., DeMaso C.R., Dowd K.A., Sutherland L.L., Scearce R.M., Parks R., Wagner W., Granados A., Greenhouse J., Walker M., Willis E., Yu J.S., McGee C.E., Sempowski G.D., Mui B.L., Tam Y.K., Huang Y.J., Vanlandingham D., Holmes V.M., Balachandran H., Sahu S., Lifton M., Higgs S., Hensley S.E., Madden T.D., Hope M.J., Karikó K., Santra S., Graham B.S., Lewis M.G., Pierson T.C., Haynes B.F., Weissman D. Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination. (2017) Nature. Feb 2. doi: 10.1038/nature21428.

Vanlandingham, D.L., Higgs, S., Huang, Y-J.S. 2016. Aedes albopictus (Diptera: Culicidae) and mosquito-borne viruses in the United States. J. Med. Entomol. 53: 1024-1028. DOI: 10.1093/jme/tjw025. PMID: 27113107.

Huang, Y. S., Ayers, V. B., Lyons, A. C., Unlu, I., Alto, B. W., Cohnstaedt, L. W., Higgs, S., Vanlandingham, D. L. 2016. Culex Species Mosquitoes and Zika Virus. Vector-Borne Zoonotic Dis. 16(10): 673-76. DOI: 10.1089/vbz.2016.2058. PMID: 27556838.

Huang, Y.J.S., Hettenbach, S.M., Park, S.L., Higgs, S., Barrett, A.D.T., Hsu, W.W., Harbin, J.N., Cohnstaedt, L.W., Vanlandingham, D.L. 2016. Differential Infectivities among Different Japanese Encephalitis Virus Genotypes in Culex quinquefasciatus Mosquitoes. PLoS Negl. Trop. Dis. 10: e0005038. DOI: 10.1371/journal.pntd.0005038. PMID: 27706157. PMCID: PMC5051684.

Dowd, K.A., Ko, S.Y., Morabito, K.M., Yang, E.S., Pelc, R.S., DeMaso, C.R., Castilho, L.R., Abbink, P., Boyd, M., Nityanandam, R., Gordon, D.N., Gallagher, J.R., Chen, X., Todd, J-P., Tsybovsky, Y., Harris, A., Huang, Y-J. S., Higgs, S., Vanlandingham, D.L., Andersen, H., Lewis, M.G., Barrera, R.D.L., Eckels, K.H., Jarman, R.G., Nason, M.C., Barouch, D.H., Roederer, M., Kong, W-P., Mascola, J-R., Pierson, T.C., Graham, B.S. 2016. Rapid development of a DNA vaccine for Zika virus. Science. 22 Sep 2016. DOI: 10.1126/science.aai9137. PMID: 27708058. PMCID: PMC5304212.

Osuna, C. E., Lim, S. Y., Deleage, C., Griffin, B. D., Stein, D., Schroeder, L. T., Omage, R., Best, K., Luo, M., Hraber, P. T., Andersen-Elyard, H., Ojeda, E. F., Huang, S., Vanlandingham, D. L., Higgs, S., Perelson, A. S., Estes, J. D., Safronetz, D., Lewis, M. G., Whitney, J. B. 2016. Zika viral dynamics and shedding in rhesus and cynomolgus macaques. Nature medicine. DOI: 10.1038/nm.4206. PMID: 27694931. PMCID: PMC5293594.

Pardi, N., Hogan, M.J., Pelc, R.S., Muramatsu, H., Andersen, H., Demaso, C.R., Dowd, K.A., Sutherland, L.L., Scearce, R.M., Parks, R., Wagner, W., Granados, A., Greenhouse, J., Walker, M., Willis, E., Yu, J-S., McGee, C.E., Sempowski, G.D., Mui, B.L., Tam, Y.K., Huang, Y-J., Vanlandingham, D., Holmes, V.M., Balachandran, H., Sahu, S., Lifton, M., Higgs, S., Hensley, S.E., Madden, T.D., Hope, M.J., Kariko, K., Santra, S., Graham, B.S., Lewis, M.G., Pierson, T.C., Haynes, B.F., Weissman, D. 2017 Zika virus protection by a single low dose nucleoside modified mRNA vaccination. Nature. 543(7644): 248-251 DOI: 10.1038/nature21428. PMID: 27694931. PMCID: PMC5293594.

Huang, Y.J.S., Lyons, A.C., Hsu, W.W., Park, S.L., Higgs, S., Vanlandingham, D.L. Differential outcomes of Zika virus infection in Aedes aegypti orally challenged with infectious blood meals and infectious protein meals. PLoS One. 12(8): e0182386. DOI: 10.1371/journal.pone.0182386. PMID: 28796799.

Review Articles

Huang YJ, Higgs S, Horne KM, Vanlandingham DL (2014) Flavivirus-mosquito interactions. Viruses. 6:4703-730 PMID: 25421894

Huang, Y.-J.S., Higgs, S., Vanlandingham, D.L. 2017. Biological Control Strategies for Mosquito Vectors of Arboviruses. Insects. 8: 21. DOI: 10.3390/insects8010021. PMID: 28208639.

Book Chapters

King CC, Chao DY, Wen TH, Kao CL, Ku CC, Wu TS, Huang YJ, Tipayamongkholgu M, Shang CS, Li YS, Wang HT, Liao MY, Wang WK, Wu HC, Chang GJ. 2008. Epidemiologic Characteristics of Dengue in Taiwan and Implications for Global Control. In Book on “Dengue”, Research Signpost, Kerala, India.

Vanlandingham, D.L., Higgs, S., Huang, Y.J.S. 2017. Arthropod Vector Biocontainment. p 399-410. In Wooley D, Byers K (ed), Biological Safety: Principles and Practices, Fifth Edition. ASM Press, Washington, DC. DOI: 10.1128/9781555819637.ch19.

Higgs, S., Huang, Y-J. S., Vanlandingham, D. L. 2017. Mosquito Modulation of Arbovirus-Host Interactions. Chapter 8. Editors Wikel,‎ S.K., Aksoy, S.,‎ and Dimopoulos, G. Arthropod Vector: Controller of Disease Transmission; Volume 2: Vector Saliva-Host-Pathogen Interactions, First Edition. Academic Press. ISBN-13: 978-0128053607.

Huang, Y-J. S., Vanlandingham, D. L., Higgs, S. Viral genetics of chikungunya virus and Zika virus and its influence in their emergence and application for public health control strategies. Editors Higgs, S., Vanlandingham, D. L., and Powers, A. M. "Current Topics in Zika and Chikungunya", Academic Press/Elsevier. In Production.