Associate Professor of Molecular Virology
MS (1997) Biology, Iowa State University
PhD (2004) Microbiology, South Dakota State University
Department of Diagnostic Medicine/Pathobiology
Kansas State University
L222 Mosier Hall
1800 Denison Avenue
Manhattan, KS 66506-5705
Phone (785) 532 -4452
Fax (785) 532-4039
Dr. Fang has been deeply involved in the study of molecular pathogenesis of porcine reproductive and respiratory syndrome virus (PRRSV). Current research program is expending to other viral pathogens. Her research interests have been focused on understanding the basic molecular mechanisms of viral pathogenesis, and applying this knowledge to develop strategies for the diagnoses, prevention and treatment of viral disease. The laboratory has well established technologies and pig model system for vaccine and diagnostic assay development. Fang’s research has been supported by research grants from National Institute of Health, the US Department of Agriculture, National Pork Board and industry partners. In collaboration with other researchers, she published more than 50 papers in peer-reviewed prestigious journals, and has been invited to give presentations by various universities and professional meetings. Dr. Fang has received various research awards, including Distinguish Researcher Award in 2013, Intellectual Property Commercialization Award in 2010, Dean’s Research Award in 2006, and research paper award in 2004.
Li, Y., E. E. Treffers, S. Napthine, A. Tas, L. Zhu, Z. Sun, S. Bell, B. L. Mark, P. A. van Veelen, M. J. van Hemert, A. E. Firth, I. Brierley, E. J. Snijder, Y. Fang. 2014. Transactivation of programmed ribosomal frameshifting by a viral protein.Proc Natl Acad Sci U S A. 111(21):E2172-81.
Snijder, E. J., M. Kikkert, Y. Fang. 2013. Arterivirus molecular biology and pathogenesis.
Journal of General Virology, Review. 94(10):2141-63.
Fang, Y., E. E. Treffers, Y. Li, A. Tas, Z. Sun, Y. van der Meer, A. H. de Ru, P. A. van Veelen, J. F. Atkins, E. J. Snijder, A. E. Firth. 2012. Efficient -2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein.Proc Natl Acad Sci U S A. 109(43):E2920-8.
Sun, Z., V. Huber, K. McCormick, R. S. Kaushik, A. C. M. Boon, L. Zhu, B. Hause, R. J. Webby, Y. Fang. 2012. Characterization of a porcine epithelial cell line for influenza virus production. Journal of General Virology. 93(9):2008-16.
Li, Y., A. Tas, E. J. Snijder, Y. Fang. 2012. Identification of Porcine Reproductive and Respiratory Syndrome Virus ORF1a-Encoded Nonstructural Proteins in Virus-Infected Cells. Journal of General Virology. 93(4):829-39.
Sun, Z., Y. Li, R. Ransburgh, E. J. Snijder, Y. Fang. 2012. Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15. Journal of Virology. 86(7):3839-50.
Langenhorst, R. J., S. Lawson, A. Kittawornrat, J. J. Zimmerman, Z. Sun, Y. Li, J. Christopher-Hennings, E. A. Nelson, Y. Fang. 2011. Development of a fluorescent microsphere immunoassay for detection of antibodies against PRRSV using oral fluid samples as an alternative to serum-based assays. Clinical Vaccine and Immunology. 19(2):180-9.
Fang, Y., and E. J. Snijder. 2010. The PRRSV replicase: Exploring the multifunctionality of an intriguing set of nonstructural proteins. Virus Research, Review. 154(1-2):61-76.
Sun, Z., Z. Chen, S. Lawson, Y. Fang. 2010. The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitination and interferon antagonism function. Journal of Virology, 84(15):7832-46.
Chen, Z., S. Lawson, Z. Sun, X. Zhou, X. Guan, J. Christopher-Hennings, E. A. Nelson, Y. Fang. 2010. Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist. Virology. 398 (1): 87-97.
Chen, Z., X. Zhou, J. K. Lunney, S. Lawson, Z. Sun, E. Brown, J. Christopher-Hennings, D. Knudsen, E. Nelson, Y. Fang. 2010. Immunodominant epitopes in nsp2 of porcine reproductive and respiratory syndrome virus are dispensable for replication but play an important role in modulation of host immune response. Journal of General Virology 91(4):1047-1057.
Fang, Y., J. Christopher-Hennings, E. Brown, H. Liu, Z. Chen, S. Lawson, R. Breen, T. Clement, X. Gao, J. Bao, D. Knudsen, R. Daly, E. Nelson. 2008. Development of Genetic Markers in the Nonstructural Protein 2 Region of a US Type 1 Porcine Reproductive and Respiratory Syndrome Virus: Implications for Future Recombinant Marker Vaccine Development. Journal of General Virology. 89:3086-3096.
Fang, Y., R. R. Rowland, M. Roof, J. K. Lunney, J. Christopher-Hennings, E. A. Nelson. 2006. A full-length cDNA infectious clone of North American type 1 porcine reproductive and respiratory syndrome virus: expression of green fluorescent protein in the nsp2 region. Journal of Virology.80(23):11447-11455.