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College of Veterinary Medicine

Yulan Xiong

Xiong

Assistant Professor

Ph.D, Lancaster University, UK
Postdoc, Johns Hopkins University School of Medicine

212 Coles Hall
Phone: 785-532-4542
Email: yulanxiong@ksu.edu

The Laboratory of Molecular Pathophysiology of Neurodegeneration 

The Xiong lab focuses on understanding the mechanisms underlying aging and neurodegenerative diseases, with specific emphasis on Parkinson’s disease (PD). PD is the most common movement disorder and currently there is no effective therapy. To develop better therapeutic treatments, Dr. Xiong’s group aims to understand the molecular pathophysiology of PD using various model systems including yeast, Drosophila, mice, primary and human neuronal cultures. The lab’s general approach is to use a powerful combination of genetics, molecular biology and behavioral analysis to decipher the molecular mechanisms underlying neurodegenerative diseases in human. The lab’s research goal is to identify molecular therapeutic targets that will ultimately lead to developing effective biomarkers and treatments for PD and related neurodegenerative diseases.

Dr. Xiong was appointed as a tenure-track Assistant Professor at the department of Neurology at the Johns Hopkins University School of Medicine before joining the faculty at K-state. She is currently supported by an NIH/NIA K01 award and The William N. & Bernice E. Bumpus foundation innovation award.

The Xiong lab welcomes motivated postdocs, undergraduate and graduate students, and research technicians to join the team.

For postdoc positions, please visit: http://www.k-state.edu/hcs/jobs/openings/5726FellowPostDoc.pdf

For PhD student openings, please visit: http://www.vet.k-state.edu/education/anatomy-physiology/academics/ and send a letter of interest, transcripts and a resume/CV listing any publications to Ms. Taylor Richter, Graduate Program co-ordinator, Department of Anatomy and Physiology, College of Veterinary Medicine, 228 Coles Hall, Kansas State University, Manhattan, KS 66506-5802, 785-532-5666, trichte@vet.k-state.edu. Letter of interest should clearly state interest in pursuing PhD with Dr. Yulan Xiong.  

Selected Publications

  1. Martin, I., Kim, J., Lee, B., Kang, H., Xu, J., Jia, H., Stankowski JN., Kim, M., Zhong, J., Kumar, M., Andrabi, S., Xiong, Y., Dickson, D., Wszolek, Z., Pandey, A., Dawson, TM, Dawson, VL. (2014) Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson’s disease. Cell 157(2):472-85.

  2. Xiong, Y., Dawson, VL, Dawson, TM. (2012) LRRK2 GTPase dysfunction in the pathogenesis of Parkinson’s disease. Biochem.Soc. Trans. 40 (5): 1074-1079

  3. Xiong, Y., Yuan, C., Chen, R., Dawson, TM. Dawson, VL. (2012) ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2. J. Neurosci. 32(11): 3877-3886.

  4. Nikonova, EV.*, Xiong, Y.*, Tanis, KQ., Moore, DJ., Dawson, VL., Vogel, RL., Finney, EM., Stone, DJ., Reynolds, IJ., Kern, JT., Dawson, TM. (2012) Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological progress modulated by LRRK2 activity. Hum. Mol. Genet. 21(1): 163-74. (* Contributed equally)

  5. Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers JW, Dawson VL, Dawson TM, Moore DJ. (2010) GTPase Activity Plays a Key Role in the Pathobiology of LRRK2. PLoS Genet. 6(4): e1000902.

  6. Zhang, J., Wang, Y., Chi, Z., Keuss, M., Pai, YM., Kang, HC., Shin, J., Byugyenko, A., Wang, H., Xiong, Y., Pletnikov, M., Mattson, M., Dawson, TM., Dawson, VL. (2011) The AAA+ ATPase Thorase regulatesAMPA receptor-dependent synaptic plasticity and behavior. Cell 145(2): 284-99.

  7. Stafa, K.,, Tsika, E.,, Moser, R., Musso, A., Glauser, L., Jones, A., Biskup, S., Xiong, Y., Bandopadhyay, R., Dawson, V., Dawson, T., Moore, D. (2014) Functional Interaction of Parkinson’s Disease-Associated LRRK2 with Members of the Dynamin GTPase Superfamily. Hum. Mol. Genet. 23 (8): 2055-77.

  8. Migheli, R., Giudice, M., Spissu, Y., Sanna, G., Xiong, Y., Dawson, TM., Dawson, VL., Galioto, M., Rochitta, G., Biosa, A., Serra, P., Carri, M., Crosio, C., Iaccarino, C. (2013) LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization. PLoS One 8(10): e77198

  9. Li, X., Moore, D.J., Xiong, Y., Dawson, T.M. and Dawson, V.L. (2010) Reevaluation of phosphorylationsites in the Parkinson disease-associated leucine-rich repeat kinase 2. J Biol Chem. 285(38): 29569-29576.