1. K-State home
  2. »College of Veterinary Medicine
  3. »Education
  4. »Anatomy and Physiology
  5. »Faculty and Staff
  6. »Faculty
  7. »Masaaki Tamura
  8. »Development of cancer-targeted nanoparticle vectors for human cancer therapy

College of Veterinary Medicine

Development of cancer-targeted nanoparticle vectors for human cancer therapy

Nanotechnology-based gene delivery systems are of great interest to us in terms of development of a practical gene therapy for non-small cell lung and pancreatic cancer. We have discovered that a unique cationic peptide NP made from two HIV-1 TAT peptides connected in tandem (dTAT) is very effective in plasmid DNA delivery in vivo. Because of the significant effect of the angiotensin II type 2 receptor gene to induce tumor cell death (Pickel et al., 2010), we are determining the efficacy of an AT2 plasmid DNA encapsulated in a dTAT NP vector conjugated with angiotensin II type 1 receptor agonist as a powerful cancer-targeted gene therapy for lung and pancreatic adenocarcinoma.

nanotechnology-based gene delivery system results