Yongming Sang PhD
Research Assistant Professor
PhD, Immunophysiology, Kansas State University, 2008
DSC, Plant Physiology and Biochemistry, Nanjing Agricultural University, 1996
My research efforts are directed at elucidating, molecularly and functionally, animal innate immune genes, in particular those that have antimicrobial activities and therapeutic potential. We are using combined approaches of bioinformatics, genetics and molecular biology to elucidate genes or gene families that are potentially important in animal innate immunity. We have focused on functional genomic studies using animal models of pigs and rats in the following two directions: (1) porcine antiviral innate immunity against porcine reproductive and respiratory syndrome virus (PRRSV); (2) innate immune responses in obesity induced by high-fat diet or/and viral infection in rats.
Schade A, Blecha F, Sang Y. (2014) Genome-wide profiling immunometabolic genes in Obese rats induced by high-fat diet synergized with infection of adenovirus serotype 36. (in preparation) (Corresponding author, and abstract was orally presented in Immunology 2014, AAI Annual Meeting, May 2-6, 2014, Pittsburgh, PA, and rewarded for 2014 AAI Early Career Faculty Travel Grant)
Sang Y, Blecha F. (2014). Alternatives to antibiotics: an ecoimmunology view. Pathogens, in press. (Invited review, corresponding author).
Sang Y, Bergkamp J, Blecha F. (2014) Molecular Evolution of the Porcine Type I Interferon Family: Subtype-Specific Expression and Antiviral Activity. Plos One, in press. Plos One (Corresponding author).
Sang Y, Rowland RRR, Blecha F. (2014) Antiviral regulation underlying the activation status of porcine monocytic innate immune cells. J. Virol. Oct 1;88(19):11395-410 (Corresponding author).
Sang Y, Brichalli W, Rowland RRR, Blecha F. (2014) Genome-wide analysis of antiviral signature genes in PRRSV-infected porcine macrophages at different activation statuses. Plos One 9: e87613. (Corresponding author).
Miller LC, Jiang Z, Sang Y, Harhay GP, Lager KM. (2014) Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheal-bronchial lymph nodes infected with influenza A virus. Vet Immunol Immunopathol 2014 Jun 15;159(3-4):180-91. (Co-corresponding author).
Dawson HD, Loveland JE, Pascal G, Gilbert JGR, Uenishi H, Mann KM, Sang Y, et al. (2013) Structural and Functional Annotation of the Porcine Immunome. BMC Genomics. 14:332.
Groenen MA, Archibald AL, Uenishi H, Tuggle CK, Takeuchi Y, Rothschild MF, Rogel-Gaillard C, Park C, Milan D, Megens HJ, Li S, Larkin DM, Kim H, Frantz LA, Caccamo M, Ahn H, Aken BL, Anselmo A, Anthon C, Auvil L, Badaoui B, Beattie CW, Bendixen C, Berman D, Blecha F, Blomberg J, Bolund L, Bosse M, Botti S, Bujie Z, Bystrom M, Capitanu B, Carvalho-Silva D, Chardon P, Chen C, Cheng R, Choi SH, Chow W, Clark RC, Clee C, Crooijmans RP, Dawson HD, Dehais P, De Sapio F, Dibbits B, Drou N, Du ZQ, Eversole K, Fadista J, Fairley S, Faraut T, Faulkner GJ, Fowler KE, Fredholm M, Fritz E, Gilbert JG, Giuffra E, Gorodkin J, Griffin DK, Harrow JL, Hayward A, Howe K, Hu ZL, Humphray SJ, Hunt T, Hornshøj H, Jeon JT, Jern P, Jones M, Jurka J, Kanamori H, Kapetanovic R, Kim J, Kim JH, Kim KW, Kim TH, Larson G, Lee K, Lee KT, Leggett R, Lewin HA, Li Y, Liu W, Loveland JE, Lu Y, Lunney JK, Ma J, Madsen O, Mann K, Matthews L, McLaren S, Morozumi T, Murtaugh MP, Narayan J, Nguyen DT, Ni P, Oh SJ, Onteru S, Panitz F, Park EW, Park HS, Pascal G, Paudel Y, Perez-Enciso M, Ramirez-Gonzalez R, Reecy JM, Rodriguez-Zas S, Rohrer GA, Rund L, Sang Y, et al. (2012) Analyses of pig genomes provide insight into porcine demography and evolution. Nature 491:393-398.
Sang Y, Shi J, Sang W, Rowland RRR, Blecha F. (2012) Replication competent recombinant PRRS viruses expressing indicator proteins and antiviral cytokines. Viruses, 4:102-116.
Sang Y, Rowland RRR, Blecha F. (2011) Interaction between innate immunity and porcine reproductive and respiratory syndrome virus. Anim Health Res Rev. 2:149-67.
Yang J, Sang Y, Meade KG, Ross C. (2011) The role of oct-1 in the regulation of tracheal antimicrobial peptide (TAP) and lingual antimicrobial peptide (LAP) expression in bovine mammary epithelial cells. Immunogenetics. 63:715-25.
Sang Y, Rowland RRR, Blecha F. (2011) Porcine type I interferons: polymorphic sequences and activity against PRRSV. BMC Proc. 5 Suppl 4:S8.