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College of Veterinary Medicine

Jim E. Riviere

Jim RiviereEmeritus Professor

DVM, PhD 1980 Purdue University
D. Sc. 2007 Purdue University

Email: jriviere@vet.k-state.edu

Elected Member, National Academy of Sciences Institute of Medicine (IOM),

Certara Establishes the Kansas State University College of Veterinary Medicine as the latest Phoenix® Center of Excellence

Strategies for Reducing Drug and Chemical Residues in Food Animals

Research Interests

Mathematical modeling of drug, chemical and nanomaterial disposition
Global Aspects of Food and Drug Safety
Comparative pharmacokinetics and prediction of drug residues in tissues of food producing animals
Pharmacokinetics and toxicokinetics of drug and xenobiotic percutaneous absorption and transdermal drug delivery
Development of in vivo and in vitro animal models for skin pharmacology
Develop QSAR models for assessing chemical mixture absorption
Develop models to study absorption and disposition of nanomaterials

Selected Publications

Riviere JE: Comparative Pharmacokinetics: Principles, Techniques and Applications. 2nd Edition, Wiley-Blackwell, Ames, IA. 2011.

Riviere JE,Papich M (eds): Veterinary Pharmacology and Therapeutics, 9th Edition. Wiley-Blackwell, Ames, IA . 2009.

Xia XX, Monteiro-Riviere NA, Riviere JE: An index for characterization of nanomaterials in biological systems. Nature Nanotechnology. 5: 671-675, 2010.

Xia XR, Monteiro-Riviere NA, Mathur S, Oldenberg S, Fadell B, Riviere JE. Mapping the surface adsorption forces of nanomaterials in biological systems using the biological surface adsorption index (BSAI) approach. ACS Nano 5: 9074-9081, 2011.

Samaras EG, Riviere JE, Ghafourian T: The effects of formulations and experimental conditions on in vitro human skin penetration – Data from updated EDETOX database. International Journal of Pharmaceutics 434: 280-291, 2012.

Sahneh FD, Scoglio C, Riviere JE: Dynamics of nanoparticle-protein corona complex. Analytical results from population balance equations. PlosOne. 8: e64690, 2013.

Riviere JE: Of mice, men and nanoparticle biocoronas: Are in vitro-in vivo correlations and interspecies extrapolations realistic? Nanomedicine. 8:1357-1359, 2013.

Buckley GJ, Riviere JE, Gostin LO: What to do about unsafe medicines? British Medical Journal 347: f5064, 2013.

Karadzovska D, Riviere JE: Assessing vehicle effects on skin absorption using artificial membrane assays. European Journal of Pharmaceutical Sciences. 50: 569-576, 2013.

Carter SG, Zhu Z, Varodi G, Veves A, Riviere JE: Vasomodulation influences on the transdermal delivery of ibuprofen. Journal of Pharmaceutical Sciences. 102: 4072-4078, 2013.

Riviere JE, Scoglio C, Sahneh F, Monteiro-Riviere NA: Computational Approaches and Metrics Needed for Formulating Biologically Realistic Nanomaterial Pharmacokinetic Models. Computational Science Discovery. 6:014005, 2013.

Chittendon J, Brooks JD, Riviere JE: Development of a mixed-effect pharmacokinetic model for vehicle modulated in vitro transdermal flux of topically applied penetrants. Journal of Pharmaceutical Sciences. 103: 1002-1012, 2014.

Li M, Gehring R, Tell L, Baynes R, Huang Q, Riviere JE: Interspecies mixed effect pharmacokinetic modeling of penicillin G in cattle and swine. Antimicrobial Agents Chemotherapy. doi:10.1128/AAC.02806-14, 2014.