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College of Veterinary Medicine

Anatomy & Physiology
College of Veterinary Medicine
Kansas State University

1620 Denison Avenue
228 Coles Hall
Manhattan, KS 66506-5802

785-532-5666

AP@vet.k-state.edu

Resources

Group Meeting Schedule

We have regular ICCM PK group meetings in the ICCM/NICKS Small Conference Room. Participants include Dr. Lin’s group members, Dr. Gehring and her group members, as well as Dr. Riviere. From May 2017, Dr. Riviere joins our group meetings via Skype. Most of Dr. Lin’s group members are co-advised by Dr. Gehring and/or Dr. Riviere. We kindly appreciate Dr. Gehring and Dr. Riviere for offering mentorship to our trainees. Besides regular group meetings, individual mentoring meetings are also available as needed.

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  • April 4, Tuesday: 2-4pm
  • April 17, Monday: 1-3pm
  • May 2, Tuesday: 2-4pm
  • May 15, Monday: 2-4pm
  • May 30, Tuesday: 2-4pm
  • June 12, Monday: 2-4pm
  • June 26, Monday: 2-4pm

Our Expertise

  • Non-compartmental pharmacokinetic analysis
  • Compartmental pharmacokinetic modeling
  • Population pharmacokinetic analysis using nonlinear mixed effects (NLME) modeling
  • Physiologically based pharmacokinetic (PBPK) modeling
  • Population physiologically based pharmacokinetic modeling using Monte Carlo simulations
  • Bayesian population physiologically based pharmacokinetic modeling using Markov chain Monte Carlo simulations
  • Pharmacokinetic-pharmacodynamic (PK/PD) modeling
  • Physiologically based pharmacokinetic-pharmacodynamic (PBPK/PD) modeling
  • Probablistic risk modeling and assessment

Our Computational Environment

Our lab has cluster computational infrastructure that is capable of performing highly advanced, complex biomedical computational modeling. Our lab is equipped with a Computer Server with Intel(R) Xeon(R) CPU E5-4650 v3 (4 X 12 core processors) and 192 GB installed memory. Lab members remotely access to the server through their desktop computers. Distance students who enroll in Dr. Lin’s class may also access to the server upon approval.

Further computational capabilities are provided by workstations housed on-site, including:

  • 4-core 3.4 GHz Intel® Core™ i7-6700 CPU processor, 32GB of RAM
  • 4-core 3.6 GHz Intel® Xeon® E5-1620 CPU processor, 26GB of RAM
  • 4-core 3.4 GHz Intel® Core™ i7-3770 CPU processor, 16GB of RAM
  • 4-core 3.4 GHz Inter® Core™ i5-3570 CPU processor, 8GB of RAM
  • 4-core 3.4 GHz Intel® Core™ i7-3770 CPU processor, 16GB of RAM
  • 4-core 3.4 GHz Intel® Core™ i5-4670 CPU processor, 16GB of RAM
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Our Computational software

  • axslX (AEgis Technologies, Inc., Huntsville, AL): PBPK modeling and simulation
  • Berkeley-Madonna (University of California at Berkeley, CA): PBPK modeling and simulation
  • Crystall Ball (Oracle Corporation, Redwood City, CA): Predictive modeling, forecasting, simulation and optimization
  • GastroPlus (Simulations Plus, Lancaster, CA): ADMET prediction, PBPK modeling, clinical trial simulation
  • GraphPad Prism 6.0 (GraphPad Software, Inc., La Jolla, CA): Graphic & statistical analysis, curve fitting (regression analysis)
  • MATLAB (The Mathworks, Inc., Natick, MA): Modeling and simulation
  • Phoenix IVIVC Toolkit 7.0 (Certara, Princeton, NJ): In vito to in vivo correlation and virtual bioequivalence analysis
  • Phoenix NLME 7.0 (Certara, Princeton, NJ): Population PK modeling with NLME approach
  • Phoenix WinNonlin 7.0 (Certara, Princeton, NJ): Pharmacokinetic analysis, PK/PD modeling and simulation
  • RStudio (RStudio Inc., Boston, MA): PBPK simulation and statistical analysis
  • SAS 9.4 (SAS Institute Inc., Cary, NC): Statistical analysis
  • SigmaStat 3.5 (Systat Software, Inc., San Jose, CA): Statistical analysis
  • Simcyp (Certara, Princeton, NJ): PBPK modeling and clinical trial simulation 
  • TableCurve 2D v5.01 (Systat Software, Inc., San Jose, CA): Dose-response analysis and curve fitting

 

Note that ICCM is a Certara® Center of Excellence, so Dr. Lin’s group members have free access to the Phoenix software suite for academic and research purposes.