1. K-State home
  2. »College of Veterinary Medicine
  3. »Education
  4. »Anatomy and Physiology
  5. »Faculty and Staff
  6. »Faculty
  7. »Zhoumeng Lin
  8. »Lin Research Group
  9. »Zhoumeng Lin Lab News

College of Veterinary Medicine

Anatomy & Physiology
College of Veterinary Medicine
Kansas State University

1620 Denison Avenue
228 Coles Hall
Manhattan, KS 66506-5802

Phone: 785-532-5666
Fax: 785-532-4557

AP@vet.k-state.edu

News

In Archive

 

  • Yi-Hsien’s story as a PBPK modeler has been highlighted in the Fall 2018 Risk Assessment Specialty Section (RASS) Newsletter. (10/30/2018)
  • Our team presented several posters and Miao gave one oral presentation in the Central States Society of Toxicology (CSSOT) Annual Meeting that took place in Manhattan, KS. Congratulations to Yu-Shin on winning the Outstanding Poster Presentation Award. Great job everyone! (10/19/2018)  
    Pic 1pic-2pic-3
    Miao’s presentation: “Application of Population Physiologically Based Pharmacokinetic (PBPK) Models and Interactive PBPK Platform for Penicillin G in Food-producing Animals to Facilitate Food Safety Assessment”; Yi-Hsien’s presentation: “Risk assessment of gold nanoparticles by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling”; Yilei’s presentation: “Assessing the breed-specific difference in the pharmacokinetics of fentanyl in dogs using physiologically based pharmacokinetic modeling”; Yu-Shin’s presentation: “A physiologically based pharmacokinetic model for penicillin G in calves”; and Sichao’s presentation: “Development of a physiologically based pharmacokinetic model for morphine in dogs”.
  • U.S. Environmental Protection Agency (EPA) hosted an External Peer Review Panel to review the potential use of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) models in the risk assessments for carbaryl, deltamethrin, and permethrin on October 12, 2018 from 12:00-1:00 PM Eastern Time. Dr. Lin served as a member in this panel. (10/12/2018)
  • Miao’s story of how he become a PBPK modeler has been published in the 2018 Summer Edition of the Biological Modeling Specialty Section (BMSS) Newsletter. Click here to read the story. (09/19/2018)
  • Our group has received a new grant from USDA to support the FARAD work. Yeah! (09/06/2018)
  • Dr. Mengjie Li from University of Oklahoma visited K-State, presented a seminar entitled “Quantitative Modeling of the Dynamics and Intracellular Trafficking of Far-Red Light-Activatable Prodrugs: Implications in Stimuli-Responsive Drug Delivery System” in Department of Anatomy and Physiology, and gave a guest lecture on “Two-Compartment Pharmacokinetic Models” for the course “Basic and Applied Pharmacokinetics”. (09/04/2018)
    pic-4
  • Wei-Chun joined us as a Postdoctoral Fellow. Welcome! (08/03/2018)
  • Miao’s manuscript entitled “Probabilistic Physiologically Based Pharmacokinetic Model for Penicillin G in Milk From Dairy Cows Following Intramammary or Intramuscular Administrations” was highlighted in the July issue of Toxicological Sciences (https://academic.oup.com/toxsci/article/164/1/1/5043108). (07/01/2018)
  • Wei-Chun joined us as a Postdoctoral Fellow. Welcome! (08/03/2018)
  • Miao’s manuscript entitled “Probabilistic Physiologically Based Pharmacokinetic Model for Penicillin G in Milk From Dairy Cows Following Intramammary or Intramuscular Administrations” was highlighted in the July issue of Toxicological Sciences (https://academic.oup.com/toxsci/article/164/1/1/5043108). (07/01/2018)
    ToxSci
  • Yu Shin joined our group as an Undergraduate Student Researcher. Welcome! (06/12/2018)
  • Dr. Lin was selected to serve as Secretary/Treasurer for the Central States Chapter of Society of Toxicology (CSSOT). (05/29/2018)
  • Trevor’s manuscript entitled “The Construction and Application of a Population Physiologically Based Pharmacokinetic Model for Methadone in Beagles and Greyhounds” was accepted by Journal of Veterinary Pharmacology and Therapeutics. Great job and congratulations! (05/18/2018)
  • Dr. Magnin-Bissel and Dr. Lin presented a poster entitled “Analytical chemistry and computational capabilities for interspecies pharmacokinetics, exposure and toxicity assessment of drugs and environmental chemicals” in the K-State Research Showcase at the Olathe campus. (05/16/2018)
    bissel-lin
  • Farewell Party for Trevor, Sichao, and Yilei. Trevor, Sichao, and Yilei will graduate in May, 2018. After graduation, Trevor will work as a PBPK modeler at the Wright–Patterson Air Force Base in   The Henry M. Jackson Foundation for the Advancement of Military Medicine. Sichao and Yilei will become a DVM student at Iowa State University and University of Minnesota, respectively. Congratulations and best wishes to you all! (05/10/2018)
    team1team 2team 3
  • Dr. Lin participated in the Annual Summit of the Food Animal Residue Avoidance Databank (FARAD) Program in Dallas, TX. (05/09/2018)
    farad
  • Dongping’s manuscript entitled “Pharmacokinetics and pharmacodynamics of tildipirosin against Pasteurella multocida in a murine lung infection model” was accepted by Frontiers in Microbiology. Great job and congratulations. (05/02/2018)
  • Yi-Hsien’s manuscript entitled “Probabilistic risk assessment of gold nanoparticles after intravenous administration by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling” was accepted by Nanotoxicology. Great job and congratulations! (03/26/2018)
  • Our team presented multiple award-winning posters and provided services to Society of Toxicology (SOT) annual meeting in San Antonio in March 2018. Our story is highlighted in the April issue of KSU CVM Lifelines. Check it out here.

    Yi-Hsien presented a poster entitled “A general physiologically based pharmacokinetic model for gold nanoparticles of different sizes with multiple administration routes in rats” and a poster entitled “Probabilistic risk assessment of gold nanoparticles by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling”. Miao presented a poster entitled “Application of population physiologically based pharmacokinetic model for penicillin G in dairy cows to facilitate food safety assessment” and a poster entitled “A preliminary physiologically based pharmacokinetic model for glyphosate in rats”. Trevor presented a poster entitled “The construction and application of a population physiologically based pharmacokinetic model for methadone in Beagles and Greyhounds”. (03/15/2018)
    sot1sot2
    sot3sot4sot5
  • Miao’s manuscript entitled “Probabilistic Physiologically Based Pharmacokinetic Model for Penicillin G in Milk from Dairy Cows following Intramammary or Intramuscular Administrations” was accepted by Toxicological Sciences. Great job and congratulations! (03/08/2018)
  • Dr. Lin served as a Grant Reviewer for the NIH Systemic Injury by Environmental Exposure (SIEE) Study Section. (03/01/2018)
  • Yi-Hsien’s abstract entitled “Probabilistic risk assessment of gold nanoparticles by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling” has been selected by the Risk Assessment Specialty Section (RASS) and Biological Modeling Specialty Section (BMSS) of the Society of Toxicology (SOT), for the Andersen-Clewell Trainee Award. Well done! (02/12/2018)
  • Yi-Hsien’s abstract entitled “A General Physiologically Based Pharmacokinetic Model For Gold Nanoparticles Of Different Sizes With Multiple Administration Routes In Rats”has been selected by the Risk Assessment Specialty Section (RASS) of the Society of Toxicology (SOT), as one of the Top 10 Best Risk-assessment Related Abstracts. Congratulations! (02/12/2018)
  • Yi-Hsien was selected to receive the 2018 Outstanding Postdoctoral Award of the Nanotoxicology Specialty Section of the Society of Toxicology at the 2018 Annual Meeting in San Antonio, TX. Congratulations! (02/12/2018)
  • Trevor was selected to receive the Committee on Diversity (CDI) Undergraduate Travel Award to attend the Undergraduate Diversity Program at the 2018 Annual Meeting of the Society of Toxicology (SOT) in San Antonio, TX. Good job and congratulations! (02/08/2018)
  • Dr. Lin served as a Grant Reviewer for the Natural Sciences and Engineering Research Council (NSERC) of Canada. (02/02/2018)
  • Yilei joined our group as Pre-Vet Student Intern. Welcome! (01/23/2018)
  • Yi-Hsien won the Society of Toxicology Biological Modeling Specialty Section Perry J. Gehring Biological Modeling Endowment Award for her work entitled “A general physiologically based pharmacokinetic model for gold nanoparticles of different sizes with multiple administration routes in rats”. Congratulations! (01/18/2018)
  • Miao’s work entitled “Application of Population Physiologically Based Pharmacokinetic Model for Penicillin G in Dairy Cows to Facilitate Food Safety Assessment” has been selected for the Society of Toxicology Biological Modeling Specialty Section Trainee Award. Congratulations! (01/18/2018)
  • Sichao joined our team as Pre-Vet Student Intern. Welcome! (01/19/2018)
  • Miao was selected to receive the Postdoctoral Excellence Award of the Regulatory and Safety Evaluation Specialty Section of the Society of Toxicology in the Annual Meeting in San Antonio in March 2018! Congratulations! (01/11/2018)
  • Dr. Lin passed the certification exam for Diplomate of the American Board of Toxicology (DABT). (11/20/2017)
  • Dr. Lin’s biography was nominated and has been accepted into Marquis Who’s Who in America (2018 Edition). (11/17/2017)
  • Dr. Lin was invited to attend the 14th Conference on Veterinary Pharmacology and Toxicology from Oct. 17-20, 2017 in Qingdao, China and to visit Department of Veterinary Pharmacology and Toxicology in Huazhong Agricultural University (HAU) from Oct. 21-26, Wuhan, China. Dr. Lin did multiple presentations and met a group of renowned pharmacologists and toxicologists in the conference. He also presented a series of lectures on PBPK modeling and discussed potential collaborative projects with Dr. Zonghui Yuan and Dr. Lingli Huang during his visit in HAU. These activities were recently highlighted at K-State Today (Nov 14) and CVM Lifelines (Nov issue). (11/14/2017)
    LinLinLin
  • Dr. Lin received the 2017-2018 K-State CVM Success for Young Investigators (SUCCESS-FYI) award to support his computational nanotechnology research. (10/30/2017)
  • Dr. Lin served as a Grant Review Panel Member on the Program of “Agriculture Systems and Technology: Nanotechnology for Agricultural and Food Systems” for USDA NIFA. (10/20/2017)
  • Dr. Lin was invited to write a Perspectives article by The Journal of Physiology. His article entitled “Advance in physiologically based pharmacokinetic modeling: from the organ level to sub-organ level based on experimental data” was accepted recently. (10/16/2017)
  • Farewell party for Dongping. Dongping will complete his one-year training in the ICCM at K-State and return back to his home university next week. Congratulations to Dongping on his excellent work and on all his achievements. Thank you for your contribution to this group. (09/29/2017)
    Lin
  • Miao, Dongping, and Yi-Hsien each did an invited seminar in Department of Anatomy and Physiology at K-State. The title of Miao’s presentation is “Application of Population Physiologically Based Pharmacokinetic Models for Penicillin G in Food-producing Animals (swine, cattle, heavy sows and dairy cows) to Facilitate Food Safety Assessment”. The title of Dongping’s presentation is “Pharmacokinetic and pharmacodynamic modeling of tildipirosin against Pasterurella multocida in a murine lung infection model”. The title of Yi-Hsien’s presentation is “Probabilistic risk assessment of gold nanoparticles (AuNPs) by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic (PBPK) model”. Excellent job! (09/25/2017)
    LinLinLin
  • Miao did an oral presentation entitled “Application of Population Physiologically Based Pharmacokinetic Models for Penicillin G in Food-producing Animals to Facilitate Food Safety Assessment” during the K-State Postdoc Appreciation Week. Good job! (09/21/2017)
  • Dr. Lin was promoted to be the Principal Investigator and the Regional Director at the Midwest Regional Center of the Food Animal Residue Avoidance Databank (FARAD) program. He received a grant from USDA NIFA to support his FARAD-related research. (09/14/2017)
    Lin
  • Dr. Lin received a R03 grant from NIH NIBIB. This is a 2-year project. The title of this project is “Physiologically based pharmacokinetic modeling and analysis of nanoparticle delivery to tumors”. Dr. DeLong is a Co-Investigator in this project. (08/30/2017)
    Lin
  • Dr. Lin served as a Representative of the ICCM and attended the meeting on “Ractopamine Residue Avoidance: Development of Scientific Strategy Meeting of Scientific Experts in the Beef Industry” in Denver, CO August 30, 2017. This meeting was organized by the National Cattlemen’s Beef Association (NCBA), the United States Meat Export Federation (USMEF), and the North American Meat Institute (NAMI). (08/30/2017)
  • Dr. Li and Dr. Lin successfully completed the Simcyp Workshop on “Hands-on experience with model-informed drug development: incorporating population variability into mechanistic prediction of PK and modeling PK-PD” held from July 10-14, 2017 in San Francisco, CA. With these two certificates, the ICCM center is eligible to install two academic licenses of Simcyp for research purposes. (07/14/2017)
    Lin
  • Dongping’s manuscript entitled “Pharmacokinetics of mequindox and its marker residue 1,4-bisdesoxymequindox in swine following repeated oral and intramuscular administration: an experimental study coupled with population physiologically based pharmacokinetic modeling” has been accepted by Journal of Agricultural and Food Chemistry. Congratulations. (06/22/2017)
  • Miao has been appointed as ad hoc Postdoctoral Representative for the Continuing Education Committee of Society of Toxicology. Congratulations and thank you for serving for the international scientific community. (06/16/2017)
  • Miao’s manuscript entitled “Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment” has been accepted by Food and Chemical Toxicology. Congratulations. (06/13/2017)
  • Dr. Lin was invited to do a webinar for the Society of Toxicology (SOT) Biological Modeling Specialty Section (BMSS). The title of his presentation is “Performance assessment and translation of individual or population physiologically based pharmacokinetic models from acslX to Berkeley Madonna, MATLAB, and R language”. The presentation will be at 11:00-11:59am on July 21st (Central Time). (06/07/2017)
  • Dongping did a poster presentation at the AAVPT Symposium. The title of his presentation is “Pharmacokinetics of mequindox and its marker residue 1,4-bisdesoxymequindox in swine following repeated oral and intramuscular administration: an experimental study coupled with population physiologically based pharmacokinetic modeling”. Good job! (05/22/2017)

news1

  • Trevor received the Most Promising Student Award in Division of Biology at K-State. Congratulations! (05/06/2017)
    Trevor
  • Dr. Lin gave a talk entitled “Physiologically based pharmacokinetic (PBPK) modeling: a tool to extrapolate from animals to humans and from cells to organisms” as part of the A&P Departmental TED Talk series. (04/10/2017)
  • Our manuscript entitled “Performance Assessment and Translation of Physiologically Based Pharmacokinetic Models from acslX to Berkeley Madonna, MATLAB, and R language: Oxytetracycline and Gold Nanoparticles as Case Examples” has been accepted for publication in Toxicological Sciences. (04/04/2017)
  • Dr. Raymond S.H. Yang visited ICCM, attended our group meeting and offered guest lectures to the PBPK modeling course. Thank you! (04/03/2017)

image2

  • Dr. Lin did a poster presentation at the SOT meeting. The title of his presentation is “Nano In-vitro Cellular Uptake Simulator (NICUS): A New Model to Quantitate Nanomaterial Endocytosis Kinetics and Intracellular Dose”. (03/14/2017)
  • Dr. Lin served as a Host Mentor for the Society of Toxicology Sunday Undergraduate Education Program. (03/12/2017)

image6

  • Miao has been selected as the Postdoctoral Representative for the Central States Society of Toxicology (CSSOT). Congratulations! (03/08/2017)
  • Miao and Trevor did oral presentations at the KSU CVM Phi Zeta Research Day. The title of Miao’s presentation is “Development and Application of a Population Physiologically Based Pharmacokinetic Model for Penicillin G in Swine and Cattle for Food Safety Assessment”. The title of Trevor’s presentation is “Development and application of a multi-route physiologically based pharmacokinetic model for methadone in Beagle and Greyhound dogs”. Good job! (03/07/2017)
image3image4

 

  • Paula Oliver from University of Chile joined us as a short-term visiting student. Welcome! (02/15/2017)
  • Dr. Lin presented an invited seminar in Department of Statistics. The title of his talk is “Applications of Population Physiologically Based Pharmacokinetic (PBPK) Models in Toxicology”. (02/09/2017)
  • Congratulations to Miao on being selected as the Postdoctoral Representative for the Society of Toxicology (SOT) Biological Modeling Specialty Section (BMSS)! (02/07/2017)
  • Dr. Jeffrey W. Fisher visited ICCM, attended our group meeting, offered guest lectures to the PBPK modeling course, and presented a seminar entitled “Using PBPK Models for Bisphenol A Safety Assessments”! Thank you! (02/06/2017) 

image5

  • Shiqiang passed his qualifying exam. Congratulations! (02/03/2017)
  • Dr. Lin successfully completed the K-State Global Campus Online Essentials course training. This training prepared Dr. Lin for teaching his online course entitled “Physiologically Based Pharmacokinetic Modeling” (AP 873) starting from the Spring 2017 semester.