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College of Veterinary Medicine

Rob DeLong, M.S., PhD

Rob DeLongAssociate Professor

Degrees

Post-doc, Pharmacology, University of North Carolina.
PhD, Biochemistry/Biophysics, Johns Hopkins

Contact

Email: robertdelong@ksu.edu, robertdelong@vet.k-state.edu
Phone: 785-532-6313

Research

Dr. Robert K. DeLong serves as associate professor in the Nanotechnology Innovation Center Kansas State within the Department of Anatomy and Physiology. The overall thrust in his research program is the impact of nanomaterials on the structure, function and delivery of nucleic acids and proteins. Research is funded by a grant entitled, “Anti-Cancer RNA Nanoconjugates” from NIH/NCI, and has received support from NSF-DMR, HHMI and APS. His group has a keen interest in the anti-cancer properties of nanoparticles when combined with RNA and is studying the nanobio interface with both RNA and protein, for potential chemotherapeutic or immunotherapeutic application against cancer and infectious disease. Dr. DeLong is a co-founder of the Journal of Biomedical Nanotechnology and continues to serve on its executive editorial board and serves as an associate editor for Reviews in Nanoscience and Nanotechnology, and the Journal of Nanotechnology and Nanomedicine Research. He has 14 patents or patent applications, 1 textbook published by Academic Press/Elsevier on biomolecular interactions for the molecular biology and biochemistry laboratory, and has published numerous book chapters and review articles on RNA nanoparticles, their characterization and delivery.  A bibliography of some recent representative publications from the group are shown below:  

Graduate Student Position available

Students interested in pursuing a PhD or DVM/PhD in the laboratory of Dr. Rob DeLong are currently being recruited. Ideally we are seeking candidates with a bachelors or masters degree in Biochemistry, Molecular Biology, Biophysics or Biotechnology with significant research experience and some exposure to nanotechnology and nanomedicine.  Students could pursue projects on RNA nanotechnology, protein and enzyme nanotechnology or RNA nanovaccines designed to target cancer and infectious disease. 

Interested candidates may contact Dr. DeLong (robertdelong@ksu.edu) for further information and are encouraged to apply early on-line (http://www.k-state.edu/grad/admissions/application-process/) and concurrently send an email with letter of interest, transcripts and a resume/CV listing any publications to Ms. Taylor Richter, Graduate Program co-ordinator, Department of Anatomy and Physiology, College of Veterinary Medicine, 228 Coles Hall, Kansas State University, Manhattan, KS 66506-5802, 785-532-5666, (trichte@vet.k-state.edu). Letter of interest should clearly state interest in pursuing PhD with Dr. DeLong.  More information can be found online at: (http://nicks.ksu.edu/people/faculty/delong/index.html) and (http://www.vet.k-state.edu/education/anatomy-physiology/faculty-staff/faculty/DeLong/index.html)

 

Representative Research Publications

DeLong RK, Curtis CB. Toward RNA nanoparticle vaccines: synergizing RNA and inorganic nanoparticles to achieve immunopotentiation.Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Jun 16. doi: 10.1002/wnan.1415. [Epub ahead of print]

 Delong RK, Hurst MN, Aryal S, Inchun NK. Unique Boron Carbide Nanoparticle Nanobio Interface: Effects on Protein-RNA Interactions and 3-D Spheroid Metastatic Phenotype. Anticancer Research 36(5): 2097-103, 2016.

Manani GN, Spidle RT, Bhaumik A, Ghosh K, Pandey RR, Chusuei CC, Delong R, Wanekaya AK. Novel aqueous fabrication and characterization of gold coated cobalt nanoparticles.  Current Bionanotechnology 1(2): 95 – 101, 2016.

Dean JM, DeLong RK. A high-throughput screening assay for the functional delivery of splice-switching oligonucleotides in human melanoma cells. Methods Mol Biol. 2015;1297:187-96. doi: 10.1007/978-1-4939-2562-9_13. PMID:25896004 

Wesley Dowler, Jacob Robison, Jonathan Fury, Xiaozheng Dou, Robert DeLong & Reza Sedaghat-Herati. Synthesis, Characterization and Applications of Poly(ethylene glycol)-block-poly(ether-sulfide) Dendrimers.  Journal of Macromolecular Science, Part A: Pure and Applied Chemistry Volume 52, Issue 1, 2015. 

Bhaumik A, Shearin AM, Delong R, Wanekaya A, Ghosh K. Probing the Interaction at the Nano-Bio Interface Using Raman Spectroscopy: ZnO Nanoparticles and Adenosine Triphosphate Biomolecules.J Phys Chem C Nanomater Interfaces. 2014 Aug 14;118(32):18631-18639. Epub 2014 Jul 29. PMID:25152799 

Venuturumilli, Sindhuri; Dean, John M.; Hurst, Miranda; DeLong, Robert K. Poly-Acrylic and Nucleic Acid Cobalt Hexamine Nanocomplexes: Characterization, RNase Protection and Inhibition of In Vitro Tumorigenicity in Soft Agar. Nanoscience and Nanotechnology Letters, Volume 6, Number 11, November 2014, pp. 976-981(6). 

Vishala S Ramyah Aaryasomayajula, Tiffany Severs, Kartik Ghosh, Robert DeLong, Xianfeng Zhang, Saikat Talapatraand Adam K Wanekaya. Assembly of a Dual Aptamer Gold Nanoparticle Conjugate Ensemble in the Specific Detection of Thrombin when Coupled with Dynamic Light Scattering Spectroscopy. J Nanomed Nanotechnol 5:210 (2014). doi: 10.4172/2157-7439.1000210. 

Reyes-Reveles J, Sedaghat-Herati R, Gilley DR, Schaeffer AM, Ghosh KC, Greene TD, Gann HE, Dowler WA, Kramer S, Dean JM, Delong RKmPEG-PAMAM-G4 nucleic acid nanocomplexes: enhanced stability, RNase protection, and activity of splice switching oligomer and poly I:C RNA. Biomacromolecules. 2013 Nov 11;14(11):4108-15. doi: 10.1021/bm4012425. Epub 2013 Oct 28. PMID:24164501 

Wayu MB, Spidle RT, Devkota T, Deb AK, Delong RK, Ghosh KC, Wanekaya AK, Chusuei CC. Morphology of hydrothermally synthesized ZnO nanoparticles tethered to carbon nanotubes affects electrocatalytic activity for H2O2 detection.Electrochim Acta. 2013 May 1;97:99-104. PMID:25684785 

Delong RK, Risor A, Kanomata M, Laymon A, Jones B, Zimmerman SD, Williams J, Witkowski C, Warner M, Ruff M, Garrad R, Fallon JK, Hickey AJ, Sedaghat-Herati R. Characterization of biomolecular nanoconjugates by high-throughput delivery and spectroscopic difference.Nanomedicine (Lond). 2012 Dec;7(12):1851-62. doi: 10.2217/nnm.12.70. Epub 2012 Sep 3. PMID:22943129 

Parker-Esquivel B, Flores KJ, Louiselle D, Craig M, Dong L, Garrad R, Ghosh K, Wanekaya A, Glaspell G, DeLong RK. Association of poly I:C RNA and plasmid DNA onto MnO nanorods mediated by PAMAM.Langmuir. 2012 Feb 28;28(8):3860-70. doi: 10.1021/la203998r. Epub 2012 Feb 14. PMID:22220841 

Barber S, Abdelhakiem M, Ghosh K, Mitchell L, Spidle R, Jacobs B, Washington L, Li J, Wanekaya A, Glaspell G, DeLong RK. Effects of nanomaterials on luciferase with significant protection and increased enzyme activity observed for zinc oxide nanomaterials.J Nanosci Nanotechnol. 2011 Dec;11(12):10309-19. PMID:22408903