November 2013 - Vol. 8, No. 11
Two CVM units make top five list of campus research departments.
Dr. Peying Fong explores molecular interactions in the thyroid gland.
Dr. Yunjeong Kim doubles down on researching infectious diseases that affect cats.
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Two CVM units make top five list of campus research departments.
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Research in the College of Veterinary Medicine at Kansas State University is leading to a better understanding of the molecular interactions in the thyroid gland related to cystic fibrosis (CF), a genetic disorder that affects the function of epithelia, tissues formed of cells that secrete and absorb an array of substances important for health. Dr. Peying Fong, associate professor in the Department of Anatomy and Physiology, has received a $285,000 grant from the Department of Health and Human Services in support of her study entitled, “CFTR Regulation of Thyroid Transport.”
“We are looking at a cellular mechanism that is essential to production of thyroxine and triiodothyronine, which are hormones that modulate development, growth and metabolism in both pre- and post-natal cell life,” Dr. Fong explained. “Iodide is an essential component of these thyroid hormones. Its rarity in the environment challenges the thyroid to orchestrate a remarkable series of transport processes that are critical for hormone synthesis.”
In addition to actively extracting iodide through the circulation process, thyroid cells must also translocate iodide into a central compartment within thyroid follicles, where it begins to combine with thyroglobulin to form the precursor to thyroid hormone.
“Through this study, we are seeking to better understand the molecular interactions between the Cystic Fibrosis Transmembrane Conductance Regulator, CFTR, and SLC5A8, which are two transport proteins found in thyroid,” Dr. Fong added. “These proteins may play a role in moving iodide into the follicular lumen.”
Dr. Fong’s project is classified by the National Institutes of Health (NIH) as an R15 Academic Research Enhancement Award. The NIH uses such awards to strengthen research environments at educational institutions as well as to promote the exposure of students to academic research. This is a renewable grant and helps cover expenses for a period of up to three years.
The laboratory also has interests in understanding how disruptions in the normal interplay between transport proteins lead to cancer. The lab works on several different epithelial systems. An undergraduate worker, Job Shiach, is studying a chloride transport protein, TMEM16A, which can be found in many epithelial tissues (including thyroid) that also express CFTR and is linked to cancer. All projects in the lab rely on the expert contributions of a postdoctoral fellow, Dr. Yonghai Li, and an assistant scientist, Ms. Suhasini Ganta.
Dr. Fong said that the groundwork for her research project originally began with funding from the K-State Center of Biomedical Research Excellence (COBRE), “Epithelial Function in Health and Disease” (NIH-P20-RR017686, Project 2), a grant-in-aid from the American Heart Association Midwest Affiliate (12GRNT12080295) and an Innovative Research Award from the Johnson Center for Basic Cancer Research at K-State.
If cats really had nine lives, one reason might be to help deal with the wide variety of diseases that threaten feline health. Dr. Yunjeong Kim, a research assistant professor in the College of Veterinary Medicine at Kansas State University, has developed a research approach that tackles two deadly infectious feline diseases at the same time. She received a $156,342 research award from the Morris Animal Foundation to support her work.
“Coronavirus and calicivirus infections are very common among cats, and cats tend to get repeatedly infected by these viruses throughout their lifetime,” explained Dr. Kim, who works in the veterinary college’s Department of Diagnostic Medicine and Pathobiology. “Feline coronavirus can cause gastroenteritis, and calicivirus often causes ulcerative upper respiratory infection with gingivitis and stomatitis. In most cases, these viral infections are mild and self-limited.”
Dr. Kim says some cats that are infected with these viruses develop life-threatening illness with high fatality. The deadly form of feline coronavirus infection, feline infectious peritonitis (FIP), has been recognized since early 1970s, and is currently the leading infectious cause of death in young cats. More recently, virulent systemic feline calicivirus infection (vs-FCV) has emerged associated with a systemic infection that is frequently fatal. Since 1998, numerous outbreaks of vs-FCV infection have been reported in animal shelters and catteries with mortality as high as 67 percent. Vaccines are available for FIP and vs-FCV but their field application seems to be limited or not recommended due to various reasons, and there is no antiviral drug for these viral infections. Because of this, there is a great need for safe and effective antiviral drugs for these diseases.
“We have been working on a virus protease that is highly conserved among some viruses, including coronavirus and calicivirus,” Dr. Kim said. “This virus protease, 3C-like protease, is essential for successful virus replication, thus it is a promising target for antiviral drug development.”
Dr. Kim is collaborating with Dr. Kyeong-Ok Chang , a virologist in the same department as Dr. Kim, and with Drs. Duy Hua and William Groutas, who are medicinal chemists at Kansas State University and Wichita State University, respectively.
“We designed a series of inhibitors for 3C-like protease, and identified a couple of promising compounds through various steps involving exploring the relationship between a compound structure and its biological activity,” Dr. Kim said. “Some of the work has been supported by an other grant from the Winn Feline Foundation. The compounds effective against FIP virus are currently under investigation for pharmacokinetic properties in cats in collaboration with Dr. Niels C. Pedersen at the University of California, Davis . This will give us valuable information that will guide our further efforts in moving forward with development of a safe and efficacious antiviral drug for FIP.”
Dr. Kim is continuing to probe into the possibility of developing antiviral compounds that are active against both FIPV and vs-FCV . The drug discovery and development process is very long and expensive, and can be fraught with difficulties.
"More and more focus has been placed on the development of broad-spectrum antiviral drugs that work against multiple viruses,” Dr. Kim explained. “That is the reason we also generated a series of compounds with broad activity against FIP and vs-FCV based on the structural and functional similarities of the proteases of these viruses. For the next three years, supported by the Morris Animal foundation grant, we will characterize those compounds for drug-like properties and also identify additional backup compounds. In addition to protease inhibitors , we identified a cellular enzyme that is important in both FIPV and FCV . The grant will also support our research on the roles of the cellular enzyme in virus replication, which may provide important insight into the pathogenicity of these viruses and also may lead to a new antiviral drug target .”
The challenge according to Dr. Kim is that an antiviral drug must not only be effective at reducing clinical symptoms and mortality, but it must also be safe and, preferably available orally.
“We are currently at an early stage and there will be many obstacles to overcome,” Dr. Kim said. “But we are encouraged by the progress we are making towards the goal.”
The FDA warns veterinarians about pet treats
The Food and Drug Administration is taking action after recent recalls of pet treats, which are causing sickness and even killing cats and dogs. Proposed regulation for safe animal food manufacturing is now open for public comment. Dr. Susan Nelson, clinical associate professor in the CVM, explained this new regulation is a way for the FDA to be more proactive in protecting our animals.
“This is a good thing for our pets,” Dr. Nelson said. “It’s exciting to see that the FDA being more proactive about the quality control for our pet foods and our pet feeds.”
On Oct. 22, the FDA issued a warning to veterinarians that jerky treats from China are making pets sick, but the cause of illness is unknown. Now, as part of the Food Safety Modernization Act, the FDA is working on a law that will regulate the manufacturing practices of pet food and treats before they hit the shelves to ensure the products are safe. It would apply to facilities that process, pack, and hold ingredients and finished products intended to be fed to livestock, pets, and other animals. The new regulation is currently open to public comment until Feb. 26. Then it will take about 60 days to enact into law.
“Compliance to the regulations by the pet food manufacturers will take a little bit of time to comply,” Dr. Nelson said. “Some of these places will need to do some changes to their current manufacturing policies so there will be a grace period for these companies to get up and running with compliance.”
If you’d like to comment on the proposed rule, it is available online on the federal register website.
Dr. Gary Anderson, director of the Kansas State Veterinary Diagnostic Laboratory in the College of Veterinary Medicine at Kansas State University, has been named as the 2013 recipient of the prestigious E.P. Pope Award presented by the American Association of Veterinary Laboratory Diagnosticians. The award provides the highest acknowledgement of those members who have made noteworthy contributions to the association, and have advanced the implementation and recognition of the specialty of veterinary diagnostic medicine. The E. P. Pope Memorial Award is presented in memory of the late Edward P. Pope. Dr. Pope was one of the founders of the association and served with distinction as its secretary-treasurer from 1959 to 1972.
“It’s a great honor to be recognized by my peers with such a distinguished award, but it’s very unexpected,” Dr. Anderson said. “This award is very little about me and very much about those around me. Before accepting the nomination to be on the officer ballot in 2007, I discussed the situation with Dr. Richardson, colleagues in the department, and my wife. I was encouraged to proceed, and have received outstanding support from everyone over the years – many have stepped up and filled gaps to allow me the privilege and opportunity to serve diagnostic medicine and our association. In reality, I truly consider this an award for K-State rather than me.”
Dr. Anderson became the director of the Kansas State Veterinary Diagnostic Laboratory in 2005. He earned a bachelor’s degree in microbiology from South Dakota State University in 1975. He then attended Kansas State University where he earned his DVM and a master’s degree in veterinary pathology in 1979. Dr. Anderson continued his studies at the University of California, Davis, under Dr. Bennie Osborn (a 1961 K-State DVM alumnus), where he received a Ph.D. in comparative pathology with a minor in immunopathology/immunovirology in 1983.
Dr. Anderson worked in the Veterinary Science Department at the University of Nebraska-Lincoln from 1983 to 1988, first as an assistant professor and later as an associate professor. In 1988, he joined Sanofi Animal Health where he was director of Development and Regulatory Affairs – Biologics, and was promoted to vice president of biological and pharmaceutical research. In 1995, Dr. Anderson formed ImmTech Biologics, where he was president, general manager and owner. In 2002, ImmTech was sold to Novartis Animal Health, and he continued to serve as vice president/director of the Immtech Division until he accepted the director position at K-State.
Dr. Anderson is a member of the American Association of Veterinary Laboratory Diagnosticians and served on the Executive Board as its vice president in 2008, president-elect in 2009, president in 2010, and past-president in 2011. He is a member of the U.S. Animal Health Association where he serves as co-chair of the AAVLD/USAHA committee on Diagnostic Laboratory and Veterinary Workforce Development. Dr. Anderson is currently co-chair of the Coordinating Council for the National Animal Health Laboratory Network and also serves on its Methods Technical Working Group. He is a member of the American Veterinary Medical Association, the Kansas Veterinary Medical Association, and the Academy of Veterinary Consultants.
Dr. Anderson received the KSU Distinguished Service Award from the Kansas Veterinary Medical Association in 2008 and the KSU Entrepreneurial Award in 2009.
The E.P. Pope Award has been awarded to other K-State veterinary alumni: Dr. Terry McElwain, DVM 1980 received the award in 2003, and Dr. Lawrence Morehouse, DVM 1952, was the recipient in 1976 in the second year after the award was established. Dr. Mahlon Vorhies, who was head of the Department of Diagnostic Medicine and Pathobiology from 1986 to 1997, received the award in 1984.
Darin Russell has been named by the Kansas State University Foundation as the new senior director of development for the College of Veterinary Medicine.
Prior to joining the foundation, Darin was the senior director of development and team lead for the Division of Agricultural Sciences and Natural Resources at the Oklahoma State University Foundation in Stillwater. Prior to that, he was the vice president for institutional advancement at Kansas Wesleyan University in Salina.
Darin is a native of Courtland, Kan., and earned a bachelor’s degree in journalism and mass communications from K-State in 1986.
”Being a lifelong Wildcat, I have worked at other institutions, but have maintained my strong love for K-State and its programs,” Darin said. “I have been associated with K-State veterinarians all my life, including an uncle, a cousin, a nephew and friends who are graduates. It’s a great honor to come back to K-State and have the opportunity to help support a college and profession that has such a tremendous reputation.”
Darin will be responsible for the direction and implementation of a comprehensive development program for raising private support for the College of Veterinary Medicine. He started the new position Oct. 14 and is located in 103 Trotter Hall.
Join us at Cat Town this fall
Tailgate with the K-State veterinary family at home football games. Cat Town provides a special opportunity for the K-State College of Veterinary Medicine family to come together prior to kickoff. We hope you will join us for food and drink. The meal for the first game will be prepared and served by the student Exotics Club. Watch the Cat Town web page for updates for each home game and pictures from the first home game.
Class Reunion Photos
This year's class reunion photos were taken by University Photo Services. To order go to http://ksuphoto.zenfolio.com/vet2013 . If you need help, please call Photographic Services under the Department of Communication and Marketing at K-State. Their number is 785-532-2535 or email email@example.com . The College of Veterinary Medicine also has a class reunion photo form available online http://www.vet.k-state.edu/depts/alumni/pdf/reunionphoto.pdf.
Class Biography order forms are available on the College of Veterinary Medicine website at http://www.vet.k-state.edu/depts/alumni/pdf/reunionbio.pdf . Thank you for submitting your updates.
20th Annual Scholarship Golf Tournament
Save the date, June 9, 2014, at Colbert Hills Golf Course. Find more information at our website:http://www.vet.k-state.edu/depts/development/golf/golf.htm
Jack the pirate prepares to commandeer some catnip, also submitted by Angela Baker.
From left, Aaron and Clara Blevins with Batgirl Peighton Canada get ready to trick-or-treat with their parents, Drs. Chris and Lindsey Blevins and Dr. Nathan Canada.
This little cubby is Noel Raphel Karote who belongs to VDL immunology research assistant Anushka George.
Ag Tech and rodeo clown Susan Hazelbaker investigates the Kind Touch statue, which had been mysteriously adorned on Halloween day.
Fourth-year students Brady Luke and Daniela Ostahowski make style statements as an homage to Dr. Walter Renberg.
Who's ready to play ball? Ag Tech Rob Reves, left, waits on deck, while fourth-year student Jeff Pearson scores as a World Series champion.
Jordy shows off his VHC spirit in scrubs. Owner Kristin Loving is the communications coordinator for the Veterinary Health Center.
VHC communications coordinator Kristin Loving and student assistant Abby Thomann hand out candy at a KSU Foundation trick-or-treating event
‘Pet Friendly’ License Plate
The College of Veterinary Medicine has a new way to support Kansas Shelter Medicine. The Pet Friendly license plate is available to Kansas residents statewide. For information, see www.vet.k-state.edu/depts/development/license.htm, call 1-855-269-7387 or e-mail: firstname.lastname@example.org.
Meet our new senior administrative specialist: Kelly Ingalsbe
By Carol Elmore
We are happy to introduce the newest Veterinary Medical Library staff member, Kelly Ingalsbe, our senior administrative specialist. Many of you already know Kelly because she formerly worked for the College of Veterinary Medicine from 1991-2005. She has worked in clinical sciences, at the large animal desk, and also in the college business office. Coming back to the library lets Kelly work again at the College of Veterinary Medicine in her words at “a challenging new job.” Kelly also worked at the Wamego City Hospital from 2005-2013. Kelly says she likes working here because the people she greets are happy and not sick and unhappy like the people she greeted when she worked at the hospital in Wamego.
Kelly grew up on a farm near Linn, Kansas, in Washington County. After graduating from Linn High School, she attended Cloud County Community College where she majored in journalism and then moved to Manhattan for her first real job. She and her husband Todd moved to Wamego in 1992 after their second daughter was born. Kelly lost her husband of 23 years in September 2011 following a four month battle with cancer.
Kelly has two daughters, Katie who is a pre-school teacher in Wamego and Tera who is a senior at Ft. Hays State University. Tera is a 6’ 1” member of the Lady Tigers at Ft. Hays. Kelly enjoys lots of sports but watching women’s basketball at Ft. Hays which begins soon is one of her favorite things to do. She’ll try to travel to as many games as possible this year.
Reading is one of Kelly’s past-times. She enjoys mysteries and says that the Hunger Games is one of her favorite books. She spends time with her adopted white, Husky-Border Collie mix dog, Poppy, and her large, white cat named PITA. When asked what we might not know about her, she mentioned a tattoo that she got after turning 40.
Kelly works at the library’s information desk and supervises all the library student employees. She’s really excited to be learning library procedures and soon will be taking an online course in PubMed. Be sure to introduce yourself to her if she doesn’t already know you the next time you come to the library.
Please visit the Veterinary Medical Library Web site: www.vet.k-state.edu/depts/library/ for help on this and other subjects.
SCAAEP practices dragging large animals out of danger
Stem cell study - call for patients
Drs. Walter Renberg, James Roush and David Upchurch would like to announce that the enrollment period is still open for an IACUC approved clinical study evaluating the use of injectable stem cells for treatment of osteoarthritis. Stem cells derived from the patient’s own fat have been used for years in human and veterinary medicine and initial reports seems promising. Potential candidates should be dogs with lameness due to arthritis of the hip joints without other confounding sources of lameness (knee disease or neurologic issues that affect the hind limbs). Candidates will need to have an initial screening by the doctors to ensure that they qualify. The study has been generously funded, and all candidate dogs will have their initial exam and subsequent procedures and visits fully funded.
If you are interested or have further questions please email Dr. Upchurch (email@example.com).
David Upchurch, DVM
The All-University Campaign for K-State is an internal fundraising effort run by campus faculty and staff volunteers specifically focused on the participation of all employees including the Manhattan campus, K-State Salina, K-State Olathe, K-State Alumni Association, KSU Foundation andK-State Athletics. It is an annual campaign for all members of the campus community to participate in by supporting the areas of the university they care about most. As of this publication date, the College of Veterinary Medicine participation rate is at 27 percent, which beats last year's participation. Support the campaign and help the CVM keep going higher. The CVM's campaign chairs are: Gail Eyestone, 532-4005 and Priscilla Roddy, 532-5663. The campaign runs through Nov. 15 so there's still time to participate. Go to http://www.found.k-state.edu/auc/ for more information, or make a gift online now.
Congratulations to Colorado Veterinary Medical Association Veterinarian of the Year, Dr. Keith A. Roehr. A 1981 graduate of K-State CVM, Dr. Roehr now lives in Broomfield, Colo. During his career with the Colorado Department of Agriculture’s Division of Animal Industry, he has helped administer the Pet Animal Care Facilities Act program and supervised the Bureau of Animal Protection.
The Comparative Medicine Group welcomes its newest agricultural technician, Marina Vilardo.
Kailey Fitzmorris and Shannon Smith, fourth-year students, presented what it is like to be a large animal veterinarian to approximately 4,000 2nd- and 3rd-grade students at the American Royal in Kansas City.
Dog N Jog presents big money to KSDS
CVM particpates in state preparedness exercise
The College of Veterinary Medicine recently participated in a two-day emergency preparedness exercise coordinated by the Kansas Department of Agriculture.
The exercise involved the Biosecurity Research Institute and several state, federal and local government agencies, as well as industry and other departments at Kansas State University. The goal of the exercise was to practice the state's foreign animal disease response plan. More than 200 individuals, including CVM faculty and students, participated in the simulated emergency, which was based on a hypothetical confirmation of foot-and-mouth disease in the United States. The CVM hosted event coordinators and observers, while working with the official state veterinarian, Dr. Justin Smith, who is a 1987 DVM alumnus.
Anatomy and Physiology Seminar Series (date, speaker and affiliation)
Seminars begin at 3:30p.m., Mara Conference Center, 4th floor, Trotter Hall, Refreshments served at 3:15p.m.
Nov. 11 Dr. Bruce Stanton, Dartmouth
Nov. 18 Dr. Bruce Schultz, Kansas State University
Nov. 25 No Seminar this week
Dec. 2 TBD
Dec. 9 Dr. Jim Eberwine, University of Pennsylvania School of Medicine (Clarenburg Lecturer)
Diagnostic Medicine/Pathobiology Seminar Series
Seminars begin at 3:30p.m., Mara Conference Center, 4th floor, Trotter Hall
Nov. 14 George Wang, PhD, Professor, Department of Human Nutrition, Kansas State University
Nov. 21 Joanne Messick, V.M.D., Ph.D., Associate Professor of Veterinary Clinical Pathology, College of Veterinary Medicine, Purdue University
Nov. 28 Thanksgiving
Dec. 5 Lee Cohnstaedt, Ph.D., Research Entomologist, Arthropod-Borne Animal Diseases Research Unit, Center for Grain and Animal Health Research, US Department of Agriculture, Agricultural
Dec. 12 Lisa Timmons, PhD, Associate Professor, Department of Molecular Biosciences, University of Kansas
K-State Olathe Veterinary Medicine Lecture Series
Lectures are at 3:30 p.m., located in K-State Olathe Forum Hall
Nov. 20 "Fleas and Ticks" Dr. Mike Dryden, University Distinguished Professor, Diagnostic Medicine/Pathobiology
Instructional Technology and Design events
Seminars are at 3:30 p.m. in the Mara Conference Center, 4th floor of Trotter Hall. More info is available here:http://www.vet.k-state.edu/depts/ITD/schedule.html
Nov. 19 Effective Creation and Use of Video Content
Matthew Warner, Research Assistant, A&P
Lifelines is published each month by the Development and Alumni Affairs Office at the College of Veterinary Medicine. The editors are Joe Montgomery, firstname.lastname@example.org, and Rebecca Martineau,email@example.com.