Lalitha Peddireddi
BVSc & AH (DVM equivalent) 2001, ANGR Agricultural University, Hyderabad, India
MS 2004, Purdue University
PhD 2009, Kansas State University
Research Assistant Professor, Molecular Diagnostics
Veterinary Diagnostic Laboratory
Mosier Hall O-245
Phone (785) 532 4425
Email: lpeddire@vet.k-state.edu
Research
My research goals are to develop and validate PCR-based molecular diagnostic assays for use in routine diagnostic setting to detect veterinary pathogens and those of zoonotic importance. My current research activities include:
Molecular Diagnostic test development and validation:
Development of molecular diagnostic tests for use within the KSVDL. I have recently developed a multiplex PCR test to detect canine respiratory bacterial and viral pathogens. This test is currently under validation. In addition, I work on molecular diagnostic projects collaborated with industry partners. These projects are primarily intended to develop and validate real-time RT-PCR based assays to diagnose a variety of veterinary pathogens including those of zoonotic potential.
Collaborative research:
I participate in clinical and collaborative research activities involving pathologists and clinicians at Kansas State University to identify the cause of an unknown illness using molecular approaches with a goal of translating basic molecular knowledge to the actual practice of clinical medicine.
Service
Molecular Diagnostics-Vector-borne and zoonotic diseases:
I oversee molecular based diagnosis of several tick-transmitted rickettsial pathogens belonging to the genera Ehrlichia (E. chaffeensis, E. canis, and E. ewingii) and Anaplasma (A. marginale, A. platys, and A. phagocytophilum) and also mosquito-borne pathogens such as West Nile Virus, which are of veterinary and public health significance.
Selected Publications:
Bonto Faburay, Huitao Liu, Lalitha Peddireddi and Roman Ganta. 2011. Isolation and characterization of Ehrlichia chaffeensis RNA polymerase and its use in evaluating p28 outer membrane protein gene promoters. BMC Microbiology, 11:83
Nickell JS, White BJ, Larson RL, Renter DR, Oberst R, Hesse R, Pedireddi L, Anderson G. 2011. Onset and Duration of Transient Infections Among Antibody- Diverse Beef Calves Exposed to a Bovine Viral Diarrhea Virus Persistently Infected Calf. J International Journal for Applied Research in Veterinary Medicine. Vol 9, No.1.
Peddireddi, L., Cheng, C. and R.R. Ganta. 2009. Promoter analysis of macrophage- and tick cell-specific differentially expressed Ehrlichia chaffeensis p28-Omp genes. BMC Microbiology, 9: 19.
Roman Reddy Ganta, Lalitha Peddireddi, Gwi-Moon Seo, Sarah Elizabeth DeDonder, Chuanmin Cheng, and Stephen Keith Chapes. 2009. Molecular characterization of Ehrlichia interactions with tick cells and macrophages. Review. Frontiers In Bioscinces. 14: 3259-73.
Lalitha Peddireddi. 2009. Transcriptional analysis and promoter characterization of two differentially expressed outer membrane protein genes of Ehrlichia chaffeensis. K-state Research Exchange.
Ganta, R.R., Cheng, C., Miller, E.C., McGuire, B.L., Peddireddi, L., Sirigireddy, K.R. and Chapes, S.K. 2007. Differential Clearance and Immune Responses to Tick Cell-Derived versus Macrophage Culture- Derived Ehrlichia chaffeensis in Mice. Infection and Immunity, 75:135-145.
Singu, V., Peddireddi, L., Sirigireddy, K.R., Cheng, C., Munderloh, U. and Ganta, R.R. 2006. Unique Macrophage and Tick Cell-specific Protein Expression from the p28/p30-Omp Multigene Locus in Ehrlichia Species. Cellular Microbiology, 8 (9), 1475-1487.
Saddoris, K.L., Peddireddi, L., Trapp, S.A., Richert, B.T., Harmon, B. and Radcliffe, J.S. 2005. The Effects of Supplemental Pantothenic Acid in Grow-Finish Pig Diets on Growth Performance and Carcass Composition. The Professional Animal Scientist. (21): 443-448.
Walsh, M.C., Peddireddi, L. and Radcliffe, J.S. 2004. Acidification of Nursery Diets : Acidification of Nursery Diets and the Role of Diet Buffering Capacity. Porknet newsletter, Tuesday, September 14 - Daily Update.
Peddireddi, L., A.L. Yager, K.L. Saddoris, L.M. Wilson, M.C. Walsh, D.M. Sholly, R.B. Hinson, B.T. Richert, and J.S. Radcliffe. 2004. The effects of dietary calcium source and level on growth performance. J. Anim. Sci. 82 (Suppl. 2): 45.
Yager, A., L. Wilson, K. Saddoris, L. Peddireddi, R. Hinson, M. Walsh, D. Sholly, B. Richert, A. Schinckel, and J.S. Radcliffe. 2004. Effects of increasing TSAA:Lys on performance and carcass characteristics of gilts fed a ractopamine step-up program. J. Anim. Sci. 82 (Suppl. 1): 99.
Peddireddi, L. and Radcliffe, J.S. 2003. The effects of dietary calcium level and citric acid supplementation on growth performance and gastrointestinal pH in chicks. J Anim. Sci Vol. (81), Supplement 2.
Radcliffe, J.S., Richert, B.T., Peddireddi, L., and Trapp, S.A.. 2003. Effects of Supplemental Pantothenic Acid During All or Part of the Grow-Finish Period on Growth Performance and Carcass Composition. Swine Research Reports. Pp 108-114.
Hinson, R., Hill, B., Walsh, M., Sholly, D., Kelly, D., Cobb, M., Peddireddi, L., Radcliffe, S., Sutton, A., Schinckel, A. and Richert. B. 2003. Effect of Feeding a Reduced Crude Protein and Reduced Phosphorus Diet on Growth Performance and Carcass Characteristics in Grow-Finish Swine. Swine Research Reports. Pp 115-124.
Hinson, R., Walsh, M., Sholly, D., Kelly, D., Cobb, M., Peddireddi, L. Radcliffe, S., Sutton, A. 2003. The effect of Feeding a Low Nutrient Excretion Diet on Growth Performance and Carcass Characteristics of Nursery, Grower, and Finisher Pigs Swine Research Reports. Pp 125-134.