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Kansas State University

Faculty

 

Richard Hesse

 

 

 

 

Richard A. Hesse, MS, PhD
Professor
Director of Diagnostic Virology
Phone (785) 532-4457
Fax  (785) 532-4481
e-mail: dhesse@vet.k-state.edu

Service, Research and Teaching

My service, research and teaching responsibilities are closely interlinked.  As Director of Diagnostic Virology, I have the opportunity to isolate, identify and characterize emerging and re-emerging viral disease agents.  Establishing ties with fellow scientists is integral to conducting research directed toward understanding the pathogenesis of diseases and developing innovative tools for rapid diagnosis.  Additional collaboration with field veterinarians, producers and researchers fosters the development of efficacious vaccines, management control strategies and scientific publications.  In the teaching environment I am further able to serve the community and university by sharing my knowledge and experience with viral diseases and vaccines.  Providing classroom instruction for veterinary and graduate students, workshops and seminars with field veterinarians and producers and noteworthy presentations at scientific meetings are all dynamic elements of my teaching responsibilities at KSU.
           
USDA VETERINARY BIOLOGICAL LICENSES AWARDED as PROJECT LEADER

Porcine Circovirus Vaccine, Type 2, Killed Baculovirus Vector, Code 19K5.RO 
Conditional License. (2005).  This circovirus vaccine was the first one licensed.  It was also the first baculovirus expressed vaccine to be licensed by USDA.

Porcine Reproductive and Respiratory Syndrome (PRRS) Vaccine: Reproductive and Respiratory Forms of Disease.  Modified Live Virus, Code 19T1.20 (1997).  This vaccine was the first and only USDA licensed PRRS vaccine that was designed to be used in sero-negative pigs for control of respiratory disease.

Porcine Reproductive and Respiratory Syndrome (PRRS) Vaccine: Reproductive Disease.  Modified Live Virus, Code 19T1.20 (1996).   This vaccine was the first and only USDA licensed PRRS vaccine that was designed to be used in sero-negative breeding stock (pre-breeding) for control of reproductive disease.

Porcine Rotavirus (Bivalent)‑Transmissible Gastroenteritis Vaccine‑Clostridium Perfringens Type C‑Escherichia Coli Bacterin‑Toxoid, Modified Live and Killed Virus, Code 49B0.20.  (1992).  This vaccine is the first and only killed bi-valent rotavirus vaccine—it is truly unique because the G4 virus was empirically designed and prepared in the laboratory to be a reassortant virus that grows to high titer, thus making the vaccine possible.

Encephalomyelitis‑Influenza Vaccine, Eastern and Western, Killed Virus, Ehrlichia Risticii‑Tetanus Bacterin‑Toxoid, Code 4A35.4.  (1992).    This vaccine was the first and is the only 6-way combination equine vaccine that includes PHF.

Encephalomyelitis‑Influenza Vaccine, Eastern and Western, Killed Virus, Tetanus Toxoid, Code 4835.00.  (1992).   Result of above combination vaccine.

Encephalomyelitis Vaccine, Eastern and Western, Killed Virus, Tetanus Toxoid, Code 4865.00.  (1992).  Result of above combination vaccine.

Porcine Rotavirus‑Transmissible Gastroenteritis Vaccine‑Clostridium Perfringens Type C‑Escherichia Coli Bacterin‑Toxoid, Modified Live and Killed Virus, Code 49B0.20.  (1990).  This vaccine was the first Killed rotavirus licensed by USDA—it was also the first 5-way killed-live combination vaccine approved by USDA.

Porcine Rotavirus Vaccine‑Clostridium Perfringens Type C‑Escherichia Coli Bacterin‑Toxoid, Killed Virus, Code 49C5.20.  (1990).    Result of above combination vaccine.

Porcine Rotavirus‑Transmissible Gastroenteritis Vaccine, Modified live and Killed Virus, Code 19H7.20.  (1990). Result of above combination vaccine.

Porcine Rotavirus Vaccine, Killed Virus, Code 19E5.20.  (1990).    Result of above combination vaccine.

Transmissible Gastroenteritis Vaccine, Modified Live Virus, Code 1961.00.  (1990).   Result of above combination vaccine.

PATENTS

Porcine Reproductive and Respiratory Syndrome Virus Strains and Compositions (Pending).

U.S. Patent 5,866,401– Porcine Reproductive and Respiratory Syndrome Vaccine (Issued February 24, 1997).

BOOK CHAPTERS

Co-authored with Dr. David Benfield, Chapter 2: Porcine Adenoviruses. For the new--Tenth Edition of  Diseases of Swine.

Co-authored with Drs. Jane Christopher-Hennings, Eric Nelson, Simone Oliveria and Gene Erickson, Chapter 7: Diagnostics tests, test performance and considerations for interpretation.  For the new--Tenth Edition of  Diseases of Swine.

 

SELECTED  PUBLICATIONS

Human Case of Swine Influenza A (H3N2) , Kansas 2009. C Cox, D. Neises, I Trevino-Garrison, B. Bryant, R. Hesse, G. Anderson, T. Gomez, B. Shu, R. Garten, A. Klimoov, L. Finelli, Submitted Emerging Infectious Diseases, Dispatch Article. (2011).

Antibody recognition of porcine circovirus type 2 capsid protein epitopes after vaccination, infection and disease. B. Trible, M. Kerrigan, N. Crossland, M. Potter, K. Faaberg, R. Hesse, R. Rowland. Clin Vaccine Immunol. 2011 Mar 23. [Epub ahead of print]

Characterization of a new disease syndrome associated with porcine circovirus type 2 (PCV2 in previously vaccinated herds.  A. Cino-Ozuna, S. Henry, R Hesse, J. Nietfeld, J. Bai, H. Scott, R. Rowland. J. Clin Microbiol. Doi:10.1128/JCM.02543-10 (2011). 

Interlaboratory comparison of PCV2 indirect immunofluorescent assay and ELISA results on experimentally infected animals.  A. Patterson, J. Johnson, S. Ramamoorthy, R. Hesse, M. Murtaugh, R. Pogranichniy, G. Erickson, S. Carman, B. Hause, X.J. Meng, T. Opriessnig. J Vet Diagn. 23:206-212  (2011)

Differential expression and activity of the porcine type I interferon family.  Y. Sang, R. Rowland, R. Hesse, F. Belcha. Physological Genomics 42: 248-258 (2010).

Onset and duration of transient infections among antibody diverse beef calves exposed to a bovine viral diarrhea virus persistently infected calf.   J. Nickell, B. White,  R. Larson, D. Renter, J Roque, R. Hesse, R. Oberst, L. Peddireddi, G. Anderson.  Intern J Appl Res Vet Med 8:29-39 (2010).

Fatal canine adenoviral pneumonia in two litters of Bulldogs.  K. Almes, K. Janardhan, J. Anderson, R. Hesse, K. Patton.  J Vet Diagn Invest. 22:780-4 (2010).

Rapid detection of the pandemic 2009 H1N1 virus M gene by real-time and gel-based RT-PCR assays.  W. Ma, Oberst, X. Li, D. Clouser, R. Hesse R. Rowland, J. Richt. Influenza Other
Respi Viruses 4:397-403. (2010).

 Identification and characterization of a highly virulent triple reassortant H1N1 swine influenza virus in the United States.  W. Ma, A. Vincent, K. Lager, B. Janke, S. Henry, R. Rowland, R. Hesse, J. Richt.  Virus Genes 40:28-36 (2009.

Evaluation of the risk of PRRSV transmission via ingestion of muscle from persistently infected pigs. R. Molina, E. Nelson, J. Christopher-Hennings, R. Hesse, R. Rowland, J. Zimmerman.
Transbound Emerg Dis. 56:1-8 (2009).
 
A Field Evaluation of Pig Mortality, Growth Performance Following Commercial vaccination Against Porcine Circovirus Type 2.  K. Horlen, S. Dritz, J. Nietfeld, S. Henry, R. Hesse, R. Oberst, M. Hays, J. Anderson, and R. Rowland.  American Journal of Veterinary Medicine,  232:906-12 (2008).

Evidence for recombination between PCV2a and PCV2b in the field.  R. Hesse, M. Kerrigan and R. Rowland.  Virus Research  132:201-7 (2008).

A Porcine G9 Rotavirus Strain Shares Neutralization and VP7 Phylogenetic Sequence Linage 3 Characteristics with Contemporary Human G9 Rotavirus Strains.  Y. Hoshino, S. Honma, R. Jones, J. Ross, N. Santos, J.Gentsch, A. Kapikian, and R. Hesse.  Virology 332:177-188 (2005)

 Enhanced Immunohistochemical Detection of Infectious Agents in Formalin Fixed Embedded Tissues following Heat-mediated Antigen Retrieval.  A. White, L. Hansen-Lardy, B. Brodersen, C. Kelling, R. Hesse, and G. Duhamel.  Journal of Veterinary Diagnostic Investigations 9:198-201 (1998). 

Renal Lesions Associated With Experimental Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection.  V. Cooper, R. Hesse, and A. Doster.  Journal of Veterinary Diagnostic Investigations 9:198-201 (1997).
 
In Vivo Detection of Porcine Reproductive and Respiratory Syndrome Virus RNA by In Situ Hybridization at Different Times Post Infection.  J. Sur, V. Cooper, J. Galeota, R. Hesse, A. Doster, and F. Osorio.  Journal of Clinical Microbiology, 34:2280-2286 (1996).

Porcine Reproductive and Respiratory Syndrome: NEB-1 PRRSV Did Not Potentiate Bacterial Pathogens. V. Cooper, A. Doster, R. Hesse, and N. Harris.  Journal of Veterinary Diagnostic Investigations 7:313-320 (1995).

Characterization of the Bovine Group A Rotavirus Strain Neonatal Calf Diarrhea Virus-Cody.  W. Lu, G. Duhamel, Y. Hoshino, D. Benfield, and R. Hesse.  Journal of Clinical Microbiology, 33:990-994 (1995).

Production and Characterization of VP4/VP7 Reassortant Swine Rotaviruses Derived from Gottfried and OSU Parental Strains.  R. Hesse, L. Couture, S. Ellsworth, E. Dickinson, G. Duhamel, W. Lu, and D. Benfield.  American Journal of Veterinary Research, 54:1623‑1629 (1993).

Effects of Bovine Parainfluenza‑3 Virus on Phagocytosis and Phagosome‑Lysosome Fusion of Cultured Bovine Alveolar Macrophages.  R. Hesse and T. Toth.  American Journal of Veterinary Research, 44: 1901‑1907 (1983).

Opsonization of Alphaviruses in Hamsters.  P.B. Jahrling, R.A. Hesse, A.O. Anderson, and J.D. Gangemi. Journal of Medical Virology, 12: 1‑16 (1983).

Replication of Five Bovine Respiratory Viruses in Cultured Bovine Alveolar Macrophages.  T.E. Toth and R.A. Hesse.  Archives of Virology, 75: 219‑224 (1983).

Elimination of Contaminating Bovine Viral Diarrhea Virus from Bovine Respiratory Syncytial Virus Stock.  T.E. Toth and R.A. Hesse.  Journal of Virological Methods, 6: 241‑244 (1983).

Pathogenesis of Lassa Virus Infection in Guinea Pigs.  P.B. Jahrling, S. Smith, R.A. Hesse and J.B. Rhoderick, Infection and Immunity.  37: 771‑778 (1982).

Pathogenesis of a Pichinde Virus Strain Adapted to Produce Lethal Infections in Guinea Pigs.  P.B. Jahrling, R.A. Hesse, J.B. Rhoderick, M.A. Elwell, and J.B. Moe.  Infection and Immunity, 32: 872‑880 (1981).

Lassa Virus Infection of Rhesus Monkeys: Pathogenesis and Treatment with Ribavirin.  P.B. Jahrling, R.A. Hesse, G.A. Eddy, K.M. Johnson, R.T. Callis, and E.L. Stephan.  The Journal of Infectious Diseases, 141: 580‑589 (1980).

Radioimmunoassay for Quantitation of Antibodies to Alphaviruses with Staphylococcal Protein A.  P.B. Jahrling, R.A. Hesse, and J.F. Metzger.  Journal of Clinical Microbiology, 8: 54‑60 (1978).

Evaluation of Vascular Clearance as a Marker for Virulence of Alphaviruses: Disassociation of Rapid Clearance with Low Virulence of Venezuelan Encephalitis Virus Strains in Guinea Pigs. P.B. Jahrling, G.B. Heisey, and R.A. Hesse.  Infection and Immunity, 17: 356‑360 (1977).