|"I have been very fortunate to work with extremely talented individuals and honored to be a part of the research community here at K-State" - Allison Jordan Bryan.|
A K-State veterinary medicine student is investigating ways to improve horse vaccinations and defend them against pathogen challenges at an early age.
Research from Allison Jordan Bryan, a graduate student in biomedical sciences and a second-year veterinary medicine student, Huntington Beach, Calif., may help protect foals as young as 3 months of age from pathogens such as West Nile virus, tetanus, equine influenza virus, Equine Herpes Virus-1, Eastern equine encephalomyelitis and Western equine encephalomyelitis.
“It is important, especially in the equine world, to vaccinate the foals as soon as possible so they will be protected against environmental pathogens they may come into contact with, even at an early age,” Allison said.
Allison recently received a second place award at the K-State Research Forum for her oral research presentation titled “Characterization of immune activation in healthy foals when vaccination is initiated at 3 months of age.”
Foals acquire maternal antibodies and immune cells that help protect them from environmental pathogens before they can fully develop their own immune systems, Allison said. Newborn foals acquire these maternal antibodies and cells through ingestion and absorption of colostrum.
Foals are usually vaccinated at 6 months of age, which gives time for maternal antibodies to decline so they do not interfere with any vaccines. But Allison is looking at the possibility of vaccinating foals at 3 months of age— the earlier age is better because it gives foals more protection against pathogens earlier in life.
“We’re trying to determine whether those maternal antibodies are still in high enough concentration at 3 months to interfere with vaccines and block the active immune response or to see if these antibodies have waned enough to allow a robust immune response,” Allison said.
She is still collecting and analyzing data. Preliminary data has indicated an immune response in 3-month-old foals, making it possible to vaccinate foals at a younger age and increase protection.