PhD, Andrology, University of Delhi, Delhi, India
MPhil, Neuroendocrinology, University of Delhi
My research program is
directed at elucidating the molecular mechanisms that underlie
alcohol-mediated alterations in gene expression in the brain.
Alcohol, one of the most abused drugs in our society, is known
to affect a number of receptor systems in the central nervous
system. Of these, the NMDA receptors have emerged as an
important site for the action of alcohol, contributing to the
development of alcohol dependence, tolerance and alcohol
withdrawal syndrome. N-methyl-D-aspartate (NMDA) receptors, the
excitatory receptors in the central nervous system, are involved
in a variety of physiological and pathological processes.
Exposure to chronic alcohol (ethanol) both in vivo and in vitro
results in an up regulation of NMDA receptor function and
number. In our laboratory, we are particularly interested in
delineating the molecular mechanism(s) by which chronic ethanol
up regulates NMDA receptor number in an in vitro model system of
fetal cortical neurons. To accomplish this goal, we employ a
multi-methodological approach that utilizes techniques in
molecular biology, biochemistry and cell culture.