PhD, Immunophysiology, Kansas State University, 2008
DSC,. Plant Physiology and Biochemistry, Nanjing Agricultural University, 1996
Research Assistant Professor
Phone (785) 532-4540
My research efforts are directed at elucidating, molecularly and functionally, animal innate immune genes, in particular those that have antimicrobial activities and therapeutic potential. We are using combined approaches of bioinformatics, genetics and molecular biology to elucidate genes or gene families that are potentially important in animal innate immunity. We have focused on functional genomics studies using animal models of pigs and rats in the following two directions, which are: (1) porcine antiviral innate immunity against porcine reproductive and respiratory syndrome virus (PRRSV); (2) innate immune responses in obesity induced by high-fat diet or/and viral infection in rats.
Sang Y, Rowland RR, Blecha F. Interaction between innate immunity and porcine reproductive and respiratory syndrome virus. Anim. Health Res. Rev. 2011, in press.
Sang Y, Rowland RR, Blecha F. Porcine type I interferons: polymorphic sequences and activity against PRRSV. BMC Proc. 2011 Jun 3; 5 Suppl 4:S8.
Yang J, Sang Y, Meade KG, Ross C. The role of oct-1 in the regulation of tracheal antimicrobial peptide (TAP) and lingual antimicrobial peptide (LAP) expression in bovine mammary epithelial cells. Immunogenetics. 2011 Nov;63(11):715-25.
Sang Y, Rowland RR, Blecha F. Molecular characterization and antiviral analyses of porcine type III interferons. J Interferon Cytokine Res. 2010 Nov;30(11):801-7.
Sang Y, Rowland RR, Hesse RA, Blecha F. Differential expression and activity of the porcine type I interferon family. Physiol Genomics. 2010 Jul 7;42(2):248-58.
Sang Y, Ruchala P, Lehrer RI, Ross CR, Rowland RR, Blecha F. Antimicrobial host defense peptides in an arteriviral infection: differential peptide expression and virus inactivation. Viral Immunol. 2009 Jul;22(4):235-42
Sang Y, Blecha F. Antimicrobial peptides and bacteriocins: alternatives to traditional antibiotics. Anim Health Res Rev. 2008 Dec;9(2):227-35.
Sang Y, Ross CR, Rowland RR, Blecha F. Toll-like receptor 3 activation decreases porcine arterivirus infection. Viral Immunol. 2008 Sep;21(3):303-13.
Sang Y, Blecha F. Porcine host defense peptides: expanding repertoire and functions. Dev Comp Immunol. 2009 Mar;33(3):334-43.
Sang Y, Yang J, Ross CR, Rowland RR, Blecha F. Molecular identification and functional expression of porcine Toll-like receptor (TLR) 3 and TLR7. Vet Immunol Immunopathol. 2008 Sep 15;125(1-2):162-7.
Sang Y, Teresa Ortega M, Rune K, Xiau W, Zhang G, Soulages JL, Lushington GH, Fang J, Williams TD, Blecha F, Melgarejo T. Canine cathelicidin (K9CATH): gene cloning, expression, and biochemical activity of a novel pro-myeloid antimicrobial peptide. Dev Comp Immunol. 2007;31(12):1278-96.
Sang Y, Patil AA, Zhang G, Ross CR, Blecha F. Bioinformatic and expression analysis of novel porcine beta-defensins. Mamm Genome. 2006 Apr;17(4):332-9.
Sang Y, Ramanathan B, Ross CR, Blecha F. Gene silencing and overexpression of porcine peptidoglycan recognition protein long isoforms: involvement in beta-defensin-1 expression. Infect Immun. 2005 Nov;73(11):7133-41.
Sang Y, Ramanathan B, Minton JE, Ross CR, Blecha F. Porcine liver-expressed antimicrobial peptides, hepcidin and LEAP-2: cloning and induction by bacterial infection. Dev Comp Immunol. 2006;30(4):357-66.
Patil AA, Cai Y, Sang Y, Blecha F, Zhang G. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Physiol Genomics. 2005 Sep 21;23(1):5-17.
Sang Y, Ortega MT, Blecha F, Prakash O, Melgarejo T. Molecular cloning and characterization of three beta-defensins from canine testes. Infect Immun. 2005 May;73(5):2611-20.