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Kansas State University

Faculty

 

Deryl Troyer

 

Deryl Troyer

DVM, Veterinary Medicine, Kansas State University, 1972 
PhD, Anatomy and Physiology, Kansas State University, 1985

Professor
Coles Hall 130
Phone: (785) 532-4509 
Email: troyer@vet.k-state.edu

 











Research interests

Cancer is a catastrophic disease that is extremely complex.   Traditional chemo or radiation therapy results in numerous off target effects that themselves can sometimes be life threatening.    Therefore, more targeted yet effective therapies are needed, along with improved detection of early stages to improve treatment outcomes.

The Cancer and Stem Cell Biology Laboratory directed by Dr. Deryl Troyer, is affiliated with the KSU Johnson Cancer Research Center and University of Kansas Cancer Center, and seeks to develop stem or defensive cells as delivery vehicles for targeted cancer therapy.    Dr. Troyer is a co-discoverer of stem cells isolated from the matrix of umbilical cords (UCMS cells), and these cells traffic to tumors and have a potent intrinsic ability to attenuate tumors.  Dr. Troyer’s laboratory has successfully used engineered UCMS cells to deliver cytokines to breast cancer, melanoma and pancreatic cancer in rodent models.   His laboratory is currently testing these and other tumor-homing cells for delivery of therapeutic nanoparticles, including superparamagnetic core/shell iron/iron oxide nanoparticles for magnetic hyperthermia and imaging in collaboration with Dr. Stefan Bossmann at KSU.    In addition, the Bossmann/Troyer labs are developing a protease sensor nanoplatform for early cancer detection.

http://themercury.com/articles/researchers-at-k-state-develop-blood-test-for-cancer-detection
http://www.youtube.com/watch?v=O8elee5Hv4U
http://www.nsf.gov/discoveries/disc_videos.jsp?cntn_id=130241&media_id=75649&org=NSF http://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=130241
http://themercury.com/articles/k-state-receives-1.3-million-for-cancer-fighting-tool

 

Selected Publications:

Wang H, Udukala D, Samarakoon T, Basel M, Abayaweera G, Manawadu H, Malalasekera A, Robinson C, Villanueva D, Maynez P, Bossmann L, Riedy E, Barriga J, Wang N, Higgins D, Zhu G, Troyer D, Bossmann S:  Synthesis and calibration of magnetic-nanoparticle (Fe/Fe3O4)-based nanoplatforms for highly sensitive fluorescence detection of cancer-related proteases.  Photochemical and Photobiological Sciences, 13(2):231-240, 2014

Kawabata  A, Ohta N, Seiler G, Seo G-M, Pyle MP, Zhang Y, Becker KG, Troyer D, Tamura M:  Naïve rat umbilical cord matrix stem cells significantly attenuate mammary tumor growth through modulation of endogenous immune responses.   Cytotherapy, 15:586-597, 2013

Shrestha T, Kalita M, Pokhrel M, Liu Y, Troyer D, Turro C, Bossmann S, Durr H:  Maleimide-functionalized photochromic spirodihydroindolizines.  The Journal of Organic Chemistry.  78(5):1903-1909, 2013  PMID: 23095100.

Perera A, Wang M, Megh R, P m, Gamage P, Kalita M, Wendel S, Sears B, Welidenlya D, Liu Y, Turro C, Troyer D, Bossmann S:  Channel blocking of MspA revisited.  Langmuir  29(1):308-315  PMID: 23214433.

Bossmann SH, Troyer DL:  Point-of-care routine rapid screening: the future of cancer diagnosis?  Expert Rev. Mol. Diagn. 13(2):107-109, 2013

Perera A, Wang H, Shrestha T, Troyer D, Bossmann S:  Nanoscopic surfactant behavior of the porin MspA in aqueous media.  Beistein Journal of Nanotechnology.  4:278-284, 2013.

Syed L, Rochford C, Wu J, Richter M, Balivada S, Troyer D, Li J:  An ultrasensitive chemiluminescence method for trace blood detection using luminol-labeled gold nanoparticles.  Analyst  138:5600-5609, 2013.

Alshetaiwi H, Balivada S, Shrestha T, Pyle M, Basel M, Bossmann S, Troyer D:  Luminol-based bioluminescence imaging of mouse mammary tumors.  Journal of Photochemistry and Photobiology B: Biology 127:223-228, 2013.

Kalita M, Balivada S, Swarup V, Mencio C, Raman K, Desai R, Troyer D, Balagurunathan K:  A nanosensor for ultrasensitive detection of oversulfated chondroitin sulfate contaminant of heparin.  Journal of the American Chemical Society  136(2):554-557, 2013

Wang H, Udukala DN, Samarakoon TN, Basel MT, Kalita M, Abayaweera G, Manawadu H, Malalasekera A, Robinson C, Villanueva D, Maynez P, Bossmann L, Riedy E, Barriga J, Wang N, Li P, Higgins DA, Zhu G, Troyer DL, Bossmann SH:  Nanoplatforms for highly sensitive fluorescence detection of cancer-related proteases.  Photochem Photobiol Sci  Epub ahead of print, 2013

Kwabata A, Ohta N, Seiler G, Pyle M, Ishiguro S, Zhang YQ, Becker KG, Troyer D, Tamura M:  Naïve rat umbilical cord matrix stem cells significantly attenuate mammary tumor growth through modulation of endogenous immune responses.  Cytotherapy  15(5):586-597, 2013.