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Kansas State University

College of Veterinary Medicine
Kansas State University
101 Trotter Hall
Manhattan, KS 66506

Dr. Masaaki Tamura Lab

 

Development of cancer-targeted nanoparticle vectors for human cancer therapy

Videomicroscopy

Nanotechnology-based gene delivery systems are of great interest to us in terms of development of a practical gene therapy for non-small cell lung and pancreatic cancer.  We have discovered that a unique cationic peptide NP made from two HIV-1 TAT peptides connected in tandem (dTAT) is very effective in plasmid DNA delivery in vivo.  Because of the significant effect of the angiotensin II type 2 receptor gene to induce tumor cell death (Pickel et al., 2010), we are determining the efficacy of an AT2 plasmid DNA encapsulated in a dTAT NP vector conjugated with angiotensin II type 1 receptor agonist as a powerful cancer-targeted gene therapy for lung and pancreatic adenocarcinoma.