PhD, Immunophysiology, Kansas State University, 1995
MS, Veterinary Immunology, Chinese Academy of Agricultural Sciences, 1988
DVM, Beijing Agricultural University, 1985
Phone (785) 532-4506
Novel adjuvants and strategies for vaccines targeting porcine reproductive and respiratory syndrome virus, classical swine fever virus, swine influenza virus, and avian influenza virus.
Molecular mechanisms of IL-1beta release from macrophages.
Selected Publications (1994-2013):
Li, X., A. Galliher-Beckley, J.C. Nietfeld, H. Huang, X. Sun, and J. Shi. 2013. Peptide nanofiber hydrogel adjuvanted live virus vaccine enhances cross-protective immunity to porcine reproductive and respiratory syndrome virus. Vaccine 31:4508-4515.
Galliher-Beckley, A., L. Lan, S. Aono, L. Wang, and J. Shi. 2013. Caspase-1 activation and mature interleukin-1β release are uncoupled events in monocytes. World Journal of Biological Chemistry 4(2): 30-34.
Li, X., A. Galliher-Beckley, J.C. Nietfeld, K.S. Faaberg, and J. Shi. 2013. MontanideTM Gel01 ST Adjuvant Enhances PRRS Modified Live Vaccine Efficacy by Regulating Porcine Humoral and Cellular Immune Responses. World Journal of Vaccines 3:1-9.
Li, Y., Wang, L., L. Pappan, A. Beckly, and J. Shi. 2012. IL-1β promotes stemness and invasiveness of colon cancer cells through Zeb1 activation. Molecular Cancer 11:87* (*Highly Accessed).
Wang, L., Z. Liu, Y., Li, L. Pappan, A. Beckly, and J. Shi. 2012. IL-1β promotes the development of intestinal epithelial stem cells. Inflammation Research, 61:1085-1092.
Zhou, Z., X. Li, Q. Liu, D. Hu, X. Yue, J. Ni, X. Yu, X. Zhai, A. Galliher-Beckley, N. Chen, J. Shi, and K. Tian. 2012. Complete genome sequence of two novel Chinese virulent porcine reproductive and respiratory syndrome virus variants. Journal of Virology, 86:6373-6374.
Yu, X., N. Chen, L. Wang, J. Wu, Z. Zhou, J. Ni, X. Li, X. Zhai, J. Shi, K. Tian. 2012. New genomic characteristics of highly pathogenic porcine reproductive and respiratory syndrome viruses do not lead to significant changes in pathogenicity. Veterinary Microbiology, 158:291-299.
*Wang, L., Z. Liu, S. Balivada, T. Shrestha, Stefan Bossmann, M. Pyle, L. Pappan, J. Shi*, and D. Troyer. 2012. IL-1β and TGF-β cooperate to reprogram glioma cells toward a glioma stem cell-like phenotype. Stem Cell Research and Therapy. 3:5. (*Co-corresponding author)
Huang, H., J. Shi, J. Laskin, Z. Liu, D.S. McVey, and X. Sun. 2011. Design of a shear-thining recoverable peptide hydrogel from native sequences and application for influenza H1N1 vaccine adjuvant. Soft Matter. 7:8905-8912.
McVey, D.S, and J. Shi. 2010. Vaccination strategies for emerging disease epidemics of livestock. Veterinary Clinics of North America - Food Animal Practice. 26:173-83.
Hu, X., C. Ward, S. Aono, L. Lan, C. Dykstra, R. Kemppainen, E. Morrison, and J. Shi. 2008. Comparative analysis of Xenopus tropicalis hepcidin I and hepcidin II genes. Gene 426:91-97.
Shi, J. 2007. Defensins and Paneth cells in inflammatory bowel disease. Inflammatory Bowel Disease 13:1284-92.
Shi, J., S. Aono, W. Lu, X. Hu, A.J. Ouellette, Y. Ji, L. Wang, S. Lenz, F. van Ginkel, M. Liles, C. Dykstra, E.E. Morrison, and C.O. Elson. 2007. A novel role for defensins in intestinal homeostasis: regulation of IL-1β secretion. The Journal of Immunology 179:1245-1253.
Aono, S., C. Li, G. Zhang, R.J. Kemppainen, J. Gard, W. Lu, X. Hu, D.D. Schwartz, E.E. Morrison, C. Dykstra, and J. Shi. 2006. Molecular and functional characterization of bovine β-defensin-1. Veterinary Immunology and Immunopathology 113:181-190.
Shi, J. and A.C. Camus. 2006. Hepcidins in amphibians and fishes: antimicrobial peptides or iron-regulatory hormones? Developmental and Comparative Immunology 30:746-755.
Shi, J., E. Talbot, D. A. DiMattia, and R. G. Dullea. 2004. The differential effects of IL-1 and TNF-α on proinflammatory cytokines and matrix metalloproteinases expression in human hondrosarcoma cells. Inflammation Research 53:277-89.
Shi, J., G. Zhang, H. Wu, C.R. Ross, F. Blecha, and T. Ganz. 1999. Porcine epithelial β-defensin-1 is expressed in the dorsal tongue at antimicrobial concentration. Infection and Immunity 67:3121-3127.
Shi, J. and T. Ganz. 1998. The role of protegrins and other elastase-activated cathelicidins in the bactericidal properties of porcine inflammatory fluids. Infection and Immunity 66:3611-3617.
Shi, J., C.R. Ross, T. L. Leto, and F. Blecha. 1996. PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p47phox. Proceedings of the National Academy of Sciences USA 93:6014-6018.
Shi, J., C.R. Ross, M.M. Chengappa, and F. Blecha. 1994. Identification of a proline-arginine-rich antibacterial peptide from neutrophils that is analogous to PR-39, an antibacterial peptide from the small intestine. Journal of Leukocyte Biology 56:807-811.