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Kansas State University



David Poole





David C. Poole

PhD, UCLA, 1986
DSc, Liverpool John Moores University, 2000

Phone (785) 532-4529  







Research Interests:

David Poole is recognized internationally for his contributions to the fields of pulmonary gas exchange and skeletal muscle structure/function relationships. He has published over 170 peer reviewed papers in journals such as Circulation Research, Journal of Clinical Investigation, American Journal of Physiology and the Journal of Applied Physiology. Dr. Poole contributes invited chapters to major textbooks and presents his work before National and international scientific audiences on a regular basis. Since 1986, Dr. Poole has been awarded over 4 million dollars in funding and currently is examining the relationships between skeletal muscle structure and oxygen delivery at the microcirculatory level. This approach is anticipated to provide unique insights into the functional abnormalities which are associated with major disease conditions such as emphysema, diabetes and chronic heart failure.

Dr. Poole's laboratory is currently funded by grants from the National Institutes of Health and encourages a vibrant scientific atmosphere which stimulates productive interactions among faculty and students. Foremost among his collaborators at K-State, Dr. Poole wishes to acknowledge the significant contributions of Dr. Thomas J. Barstow, Dr. Timothy I. Musch, Dr. Howard H. Erickson, Dr. M. Roger Fedde, Dr. Casey A. Kindig and Dr. Brad J. Behnke.

In collaboration with Professor Andrew M. Jones of Manchester Metropolitan University in England, Dr. Poole has recently published a textbook entitled: "Oxygen Uptake Kinetics in Sport, Exercise and Medicine." This book is published by Routledge, London and New York, 2005, ISBN #-0-415-30560-8 (hardback) and 0-415-30561-6 (softback).

Selected Publications:

Hirai, D.M., S.W. Copp, P.J. Schwagerl, T.I. Musch, and D.C. Poole. Acute effects of hydrogen peroxide on skeletal muscle microvascular oxygenation from rest to contractions. J. Appl. Physiol. 110: 1290-8, 2011.

Copp, S.W., D.M. Hirai, S.K. Ferguson, T.I. Musch, and D.C. Poole. Role of neuronal nitric oxide synthase in modulating microvascular and contractile function in rat skeletal muscle.Microcirculation. 18: 501-11, 2011.

Koga, S., D.C. Poole, Y. Fukuoka, L.F. Ferreira, N. Kondo, E. Ohmae, and T.J. Barstow. Methodological validation of the dynamic heterogeneity of muscle deoxygenation within the quadriceps during cycle exercise. Am. J. Physiol. Regul.  Integr. Comp. Physiol. 301(2):R534-41, 2011.

Hirai, D.M., S.W. Copp, K.S. Hageman, D.C. Poole, and T.I. Musch. Aging alters the contribution of nitric oxide to regional muscle hemodynamic control at rest and during exercise in rats. J. Appl. Physiol. 111: 989-98, 2011.

Kano, Y., D.C. Poole, M. Sudo, S. Miura, and O. Ezaki. Control of microvascular PO2 kinetics following onset of muscle contractions: Role for AMPK.  Am. J. Physiol. Regul. Integr. Comp. Physiol. 301: 1350- 7, 2011.

Koga, S., Y. Kano, T.J. Barstow, L.F. Ferreira, E. Ohmae, M. Sudo, and D.C. Poole. Kinetics of muscle deoxygenation and microvascular PO2 during contractions in rat: Comparison of optical spectroscopy and phosphorescence-quenching techniques.  J. Appl. Physiol. 112: 26-32, 2012.

Copp, S.W., D.H. Hirai, S.K. Ferguson, C.T. Holdsworth, T.I. Musch, and D.C. Poole. Effects of chronic heart failure on neuronal nitric oxide synthase- mediated control of microvascular O2 pressure in contracting rat skeletal muscle.” J. Physiol.  590(Pt 15):3585-96, 2012.

Hirai, D.M., S.W. Copp, S.K. Ferguson, C.T. Holdsworth, T.I. Musch, and D.C. Poole. Exercise training and muscle microvascular oxygenation: Role of nitric oxide bioavailability.  J. Appl. Physiol. 113: 557-65, 2012.

Hirai, D.M., S.W. Copp, S.K. Ferguson, C.T. Holdsworth, D.C. Poole, and T.I. Musch. Effects of neuronal nitric oxide synthase inhibition on microvascular and contractile function in skeletal muscle of aged rats. Am. J. Physiol. Heart Cir. Physiol. 303(8):H1076-84, 2012.

Copp, S.W., P.J. Schwagerl, D.M. Hirai, D.C. Poole, and T.I. Musch. Acute ascorbic acid and hindlimb skeletal muscle blood flow distribution in old rats: rest and exercise. Can. J. Physiol. Pharmacol. 90: 1-8, 2012.       

Ferguson, S.K., D.M. Hirai, S.W. Copp, C.T. Holdsworth, J.D. Allen, A.M. Jones, T.I. Musch, and D.C. Poole. Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats. J. Physiol. In press, 2012.