Skip to the content

Kansas State University

Faculty

 

Butch KuKanich

 

Butch KuKanich

DVM, VA-MD Regional College of Veterinary Medicine, Virginia Tech, 1997
PhD, Comparative Biomedical Sciences, NC State University, 2005
Diplomate, ACVCP

Associate Professor
Mosier Hall P212
Phone (785) 532-4554
Email: kukanich@ksu.edu


 

 

 

 

 

 

Research Interests:

The focus of the Analytical Pharmacology Laboratory at Kansas State University is the evaluation and design of rational drug dosages through the use of pharmacokinetic, pharmacodynamic, and pharmacokinetic-pharmacodynamic studies. The analytical methodology currently available in the Analytical Pharmacology Laboratory includes: HPLC, LC/MS, and florescence polarization immunoassay (FPIA). The evaluation of analgesics and analgesic adjuncts in companion animals is an area of current research for the laboratory. The assessment of opioids, NMDA antagonists, adrenergic agonists, and GABA-ergic drugs compromise the bulk of the efforts. Additionally, collaborative studies in all areas of pharmacology are supported by the laboratory through analytical methodology, pharmacokinetic, and pharmacokinetic-pharmacodynamic modeling.

Selected Publications:

Hahn A, D'Agostino J, Cole G, Kukanich B. Pharmacokinetics of selamectin in helmeted guineafowl (Numida meleagris) after topical administration. J Zoo Wildl Med. 2014 Mar;45(1):176-8. PubMed PMID: 24712181.

Kukanich B, Allen P. Comparative pharmacokinetics of intravenous fentanyl and buprenorphine in healthy greyhound dogs. J Vet Pharmacol Ther. 2014 Mar 29. doi:  10.1111/jvp.12129. [Epub ahead of print] PubMed PMID: 24684621.

Coetzee JF, Mosher RA, Anderson DE, Robert B, Kohake LE, Gehring R, White BJ,  Kukanich B, Wang C. Impact of oral meloxicam administered alone or in combination with gabapentin on experimentally induced lameness in beef calves. J Anim Sci. 2014 Feb;92(2):816-29. doi: 10.2527/jas.2013-6999. Epub 2014 Jan 14. PubMed PMID: 24664569.

Kukanich K, Kukanich B, Harris A, Heinrich E. Effect of sucralfate on oral minocycline absorption in healthy dogs. J Vet Pharmacol Ther. 2014 Mar 10. doi: 10.1111/jvp.12116. [Epub ahead of print] PubMed PMID: 24611544.

Delk KW, Carpenter JW, KuKanich B, Nietfeld JC, Kohles M. Pharmacokinetics of meloxicam administered orally to rabbits (Oryctolagus cuniculus) for 29 days. Am  J Vet Res. 2014 Feb;75(2):195-9. doi: 10.2460/ajvr.75.2.195. PubMed PMID: 24471756.

Guzman DS, Drazenovich TL, KuKanich B, Olsen GH, Willits NH, Paul-Murphy JR. Evaluation of thermal antinociceptive effects and pharmacokinetics after intramuscular administration of butorphanol tartrate to American kestrels (Falco sparverius). Am J Vet Res. 2014 Jan;75(1):11-8. doi: 10.2460/ajvr.75.1.11. PubMed PMID: 24370240.

Bach JE, Kukanich B, Papich MG, McKiernan BC. Evaluation of the bioavailability and pharmacokinetics of two extended-release theophylline formulations in dogs. J Am Vet Med Assoc. 2004 Apr 1;224(7):1113-9. PubMed PMID: 15074856.

KuKanich B, Papich M, Huff D, Stoskopf M. Comparison of amikacin pharmacokinetics in a killer whale (Orcinus orca) and a beluga whale (Delphinapterus leucas). J Zoo Wildl Med. 2004 Jun;35(2):179-84. PubMed PMID: 15305513.

KuKanich B, Papich MG. Pharmacokinetics of tramadol and the metabolite O-desmethyltramadol in dogs. J Vet Pharmacol Ther. 2004 Aug;27(4):239-46. PubMed PMID: 15305853.

KuKanich B, Papich MG. Plasma profile and pharmacokinetics of dextromethorphan after intravenous and oral administration in healthy dogs. J Vet Pharmacol Ther. 2004 Oct;27(5):337-41. PubMed PMID: 15500572.

KuKanich B, X Lascelles BD, Papich MG. Validation of a high-pressure liquid chromatography and fluorescence polarization immunoassay for the determination of methadone in canine plasma. Ther Drug Monit. 2005 Jun;27(3):389-92. PubMed PMID: 15905812.

KuKanich B, Lascelles BD, Papich MG. Pharmacokinetics of morphine and plasma concentrations of morphine-6-glucuronide following morphine administration to dogs. J Vet Pharmacol Ther. 2005 Aug;28(4):371-6. PubMed PMID: 16050817.

Gore SR, Harms CA, KuKanich B, Forsythe J, Lewbart GA, Papich MG. Enrofloxacin pharmacokinetics in the European cuttlefish, Sepia officinalis, after a single i.v. injection and bath administration. J Vet Pharmacol Ther. 2005 Oct;28(5):433-9. PubMed PMID: 16207305.

KuKanich B, Lascelles BD, Aman AM, Mealey KL, Papich MG. The effects of inhibiting cytochrome P450 3A, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogs. J Vet Pharmacol Ther. 2005 Oct;28(5):461-6. PubMed PMID: 16207309.

KuKanich B, Lascelles BD, Papich MG. Assessment of a von Frey device for evaluation of the antinociceptive effects of morphine and its application in pharmacodynamic modeling of morphine in dogs. Am J Vet Res. 2005 Sep;66(9):1616-22. PubMed PMID: 16261837.

KuKanich B, Gehring R, Webb AI, Craigmill AL, Riviere JE. Effect of formulation and route of administration on tissue residues and withdrawal times.  J Am Vet Med Assoc. 2005 Nov 15;227(10):1574-7. Review. PubMed PMID: 16313034.

KuKanich B, Lascelles BD, Papich MG. Use of a von Frey device for evaluation  of pharmacokinetics and pharmacodynamics of morphine after intravenous administration as an infusion or multiple doses in dogs. Am J Vet Res. 2005 Nov;66(11):1968-74. PubMed PMID: 16334958.

Milligan M, KuKanich B, Beard W, Waxman S. The disposition of lidocaine during a 12-hour intravenous infusion to postoperative horses. J Vet Pharmacol Ther. 2006 Dec;29(6):495-9. PubMed PMID: 17083453.

Uhrig SR, Papich MG, KuKanich B, Mama KR, Wagner AE, Chapman PL, Hellyer PW. Pharmacokinetics and pharmacodynamics of morphine in llamas. Am J Vet Res. 2007 Jan;68(1):25-34. PubMed PMID: 17199415.

KuKanich B, Huff D, Riviere JE, Papich MG. Naïve averaged, naïve pooled, and  population pharmacokinetics of orally administered marbofloxacin in juvenile harbor seals. J Am Vet Med Assoc. 2007 Feb 1;230(3):390-5. PubMed PMID: 17269873.

Milligan M, Beard W, KuKanich B, Sobering T, Waxman S. The effect of lidocaine on postoperative jejunal motility in normal horses. Vet Surg. 2007 Apr;36(3):214-20. PubMed PMID: 17461945.

Coetzee JF, Gehring R, Bettenhausen AC, Lubbers BV, Toerber SE, Thomson DU, KuKanich B, Apley MD. Attenuation of acute plasma cortisol response in calves following intravenous sodium salicylate administration prior to castration. J Vet Pharmacol Ther. 2007 Aug;30(4):305-13. PubMed PMID: 17610403.

KuKanich B, Coetzee JF, Gehring R, Hubin M. Comparative disposition of pharmacologic markers for cytochrome P-450 mediated metabolism, glomerular filtration rate, and extracellular and total body fluid volume of Greyhound and Beagle dogs. J Vet Pharmacol Ther. 2007 Aug;30(4):314-9. PubMed PMID: 17610404.

KuKanich B, Hogan BK, Krugner-Higby LA, Smith LJ. Pharmacokinetics of hydromorphone hydrochloride in healthy dogs. Vet Anaesth Analg. 2008 May;35(3):256-64. Epub 2008 Feb 18. PubMed PMID: 18282253.

KuKanich B, Borum SL. The disposition and behavioral effects of methadone in  Greyhounds. Vet Anaesth Analg. 2008 May;35(3):242-8. Epub 2008 Feb 18. PubMed PMID: 18282261.

KuKanich B, Coetzee JF. Comparative pharmacokinetics of amikacin in Greyhound and Beagle dogs. J Vet Pharmacol Ther. 2008 Apr;31(2):102-7. PubMed PMID: 18307501.

KuKanich B, Borum SL. Effects of ketoconazole on the pharmacokinetics and pharmacodynamics of morphine in healthy Greyhounds. Am J Vet Res. 2008 May;69(5):664-9. PubMed PMID: 18447799.

Smith LJ, KuKanich B, Hogan BK, Brown C, Heath TD, Krugner-Higby LA. Pharmacokinetics of a controlled-release liposome-encapsulated hydromorphone administered to healthy dogs. J Vet Pharmacol Ther. 2008 Oct;31(5):415-22. PubMed PMID: 19000260.

KuKanich B, Schmidt BK, Krugner-Higby LA, Toerber S, Smith LJ. Pharmacokinetics and behavioral effects of oxymorphone after intravenous and subcutaneous administration to healthy dogs. J Vet Pharmacol Ther. 2008 Dec;31(6):580-3. PubMed PMID: 19000282.

Coetzee J, Kukanich B, Mosher R, Allen P. Pharmacokinetics of intravenous and oral meloxicam in ruminant calves. Vet Ther. 2009 Winter;10(4):E1-8. PubMed PMID: 20425727.

Henao-Guerrero PN, McMurphy R, KuKanich B, Hodgson DS. Effect of morphine on the bispectral index during isoflurane anesthesia in dogs. Vet Anaesth Analg. 2009 Mar;36(2):133-43. PubMed PMID: 19239651.

Krugner-Higby L, KuKanich B, Schmidt B, Heath TD, Brown C, Smith LJ. Pharmacokinetics and behavioral effects of an extended-release, liposome-encapsulated preparation of oxymorphone in rhesus macaques. J Pharmacol  Exp Ther. 2009 Jul;330(1):135-41. Epub 2009 Apr 7. PubMed PMID: 19351868; PubMed Central PMCID: PMC2700165.

Margiocco ML, Warren J, Borgarelli M, KuKanich B. Analysis of weight uniformity, content uniformity and 30-day stability in halves and quarters of routinely prescribed cardiovascular medications. J Vet Cardiol. 2009 Jun;11(1):31-9. Epub 2009 May 28. PubMed PMID: 19477704.

Kotschwar JL, Coetzee JF, Anderson DE, Gehring R, KuKanich B, Apley MD. Analgesic efficacy of sodium salicylate in an amphotericin B-induced bovine synovitis-arthritis model. J Dairy Sci. 2009 Aug;92(8):3731-43. PubMed PMID: 19620655.

Kukanich B, Cohen RL. Pharmacokinetics of oral gabapentin in greyhound dogs.  Vet J. 2011 Jan;187(1):133-5. Epub 2009 Oct 23. PubMed PMID: 19854080; PubMed Central PMCID: PMC2891228.

Aperce CC, Burkey TE, KuKanich B, Crozier-Dodson BA, Dritz SS, Minton JE. Interaction of Bacillus species and Salmonella enterica serovar Typhimurium in immune or inflammatory signaling from swine intestinal epithelial cells. J Anim Sci. 2010 May;88(5):1649-56. Epub 2010 Jan 15. PubMed PMID: 20081082.

KuKanich B. Pharmacokinetics of acetaminophen, codeine, and the codeine metabolites morphine and codeine-6-glucuronide in healthy Greyhound dogs. J Vet Pharmacol Ther. 2010 Feb;33(1):15-21. PubMed PMID: 20444020; PubMed Central PMCID: PMC2867071.

KuKanich B, Hubin M. The pharmacokinetics of ketoconazole and its effects on  the pharmacokinetics of midazolam and fentanyl in dogs. J Vet Pharmacol Ther. 2010 Feb;33(1):42-9. PubMed PMID: 20444024.

Rush BR, Hafen M Jr, Biller DS, Davis EG, Klimek JA, KuKanich B, Larson RL, Roush JK, Schermerhorn T, Wilkerson MJ, White BJ. The effect of differing Audience Response System question types on student attention in the veterinary medical classroom. J Vet Med Educ. 2010 Summer;37(2):145-53. PubMed PMID: 20576903.

Grady JA, Davis EG, KuKanich B, Sherck AB. Pharmacokinetics and pharmacodynamics of dexamethasone after oral administration in apparently healthy horses. Am J Vet Res. 2010 Jul;71(7):831-9. PubMed PMID: 20594087.

Coetzee JF, Mosher RA, Kohake LE, Cull CA, Kelly LL, Mueting SL, KuKanich B.  Pharmacokinetics of oral gabapentin alone or co-administered with meloxicam in ruminant beef calves. Vet J. 2010 Sep 23. [Epub ahead of print] PubMed PMID: 20869892.

KuKanich B. Clinical interpretation of pharmacokinetic and pharmacodynamics data in zoologic companion animal species. Vet Clin North Am Exot Anim Pract. 2011 Jan;14(1):1-20. Review. PubMed PMID: 21074699.

Krugner-Higby L, KuKanich B, Schmidt B, Heath TD, Brown C. Pharmacokinetics and behavioral effects of liposomal hydromorphone suitable for perioperative use  in rhesus macaques. Psychopharmacology (Berl). 2011 Aug;216(4):511-23. Epub 2011 Mar 15. PubMed PMID: 21404039; PubMed Central PMCID: PMC3142292.

Kukanich B, Papich MG. Pharmacokinetics and antinociceptive effects of oral tramadol hydrochloride administration in Greyhounds. Am J Vet Res. 2011 Feb;72(2):256-62. PubMed PMID: 21281202.

Kukanich B. Pharmacokinetics of subcutaneous fentanyl in Greyhounds. Vet J. 2011 Mar 7. [Epub ahead of print] PubMed PMID: 21388844.

KuKanich B. Analgesia and pain assessment in veterinary research and clinical trials. Vet J. 2011 Apr;188(1):1-2. PubMed PMID: 21411352.

Williams MM, Davis EG, KuKanich B. Pharmacokinetics of oral terbinafine in horses and Greyhound dogs. J Vet Pharmacol Ther. 2011 Jun;34(3):232-7. doi: 10.1111/j.1365-2885.2010.01213.x. PubMed PMID: 21492187; PubMed Central PMCID: PMC3078771.

KuKanich B, Kukanich KS, Rodriguez JR. The effects of concurrent administration of cytochrome P-450 inhibitors on the pharmacokinetics of oral methadone in healthy dogs. Vet Anaesth Analg. 2011 May;38(3):224-30. doi: 10.1111/j.1467-2995.2011.00602.x. PubMed PMID: 21492388.

Sanchez-Migallon Guzman D, KuKanich B, Keuler NS, Klauer JM, Paul-Murphy JR. Antinociceptive effects of nalbuphine hydrochloride in Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res. 2011 Jun;72(6):736-40. PubMed PMID: 21627517.

Keller DL, Sanchez-Migallon Guzman D, Klauer JM, KuKanich B, Barker SA, Rodríguez-Ramos Fernández J, Paul-Murphy JR. Pharmacokinetics of nalbuphine hydrochloride after intravenous and intramuscular administration to Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res. 2011 Jun;72(6):741-5. PubMed PMID: 21627518.

KuKanich B, Nauss JL. Pharmacokinetics of the cytochrome P-450 substrates phenytoin, theophylline, and diazepam in healthy Greyhound dogs. J Vet Pharmacol  Ther. 2011 Jun 22. doi: 10.1111/j.1365-2885.2011.01316.x. [Epub ahead of print] PubMed PMID: 21692812.

Shang Q, Wang X, Apley M, KuKanich SB, Berkland C. PPF microsphere depot sustains NSAID blood levels with infusion-like kinetics without 'burst'. J Vet Pharmacol Ther. 2011 Jun 23. doi: 10.1111/j.1365-2885.2011.01317.x. [Epub ahead of print] PubMed PMID: 21696401.

Mosher RA, Coetzee JF, Cull CA, Gehring R, KuKanich B. Pharmacokinetics of oral meloxicam in ruminant and preruminant calves. J Vet Pharmacol Ther. 2011 Aug 29. doi: 10.1111/j.1365-2885.2011.01331.x. [Epub ahead of print] PubMed PMID: 21883284.

Baldridge SL, Coetzee JF, Dritz SS, Reinbold JB, Gehring R, Havel J, KuKanich B. Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves following castration and dehorning. Am J Vet Res. 2011 Oct;72(10):1305-17. PubMed PMID: 21962272.

Coetzee JF, Edwards LN, Mosher RA, Bello NM, O'Connor AM, Wang B, KuKanich B, Blasi DA. Effect of oral meloxicam on health and performance of beef steers relative to bulls castrated upon arrival at the feedlot. J Anim Sci. 2011 Sep 30. [Epub ahead of print] PubMed PMID: 21965454.

Coetzee JF, Mosher RA, KuKanich B, Gehring R, Robert B, Reinbold B, White BJ.  Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves following scoop dehorning without local anesthesia. BMC Vet Res. 2012 Sep 1;8(1):153. PubMed PMID: 22937949.

Wack AN, KuKanich B, Bronson E, Denver M. Pharmacokinetics of enrofloxacin after single dose oral and intravenous administration in the African penguin (Spheniscus demersus). J Zoo Wildl Med. 2012 Jun;43(2):309-16. PubMed PMID: 22779234.

KuKanich B, Clark TP. The history and pharmacology of fentanyl: relevance to a novel, long-acting transdermal fentanyl solution newly approved for use in dogs.  J Vet Pharmacol Ther. 2012 Aug;35 Suppl 2:3-19. PubMed PMID: 22731771.

KuKanich B. Geriatric veterinary pharmacology. Vet Clin North Am Small Anim Pract. 2012 Jul;42(4):631-42, v. Epub 2012 May 10. PubMed PMID: 22720805.

Kreuder AJ, Coetzee JF, Wulf LW, Schleining JA, KuKanich B, Layman LL, Plummer PJ. Bioavailability and pharmacokinetics of oral meloxicam in llamas. BMC Vet Res. 2012 Jun 21;8(1):85. PubMed PMID: 22720782.

Carpenter JW, Dryden MW, KuKanich B. Pharmacokinetics, efficacy, and adverse effects of selamectin following topical administration in flea-infested rabbits.  Am J Vet Res. 2012 Apr;73(4):562-6. PubMed PMID: 22452505.

Malreddy PR, Coetzee JF, KuKanich B, Gehring R. Pharmacokinetics and milk secretion of gabapentin and meloxicam co-administered orally in Holstein-Friesian cows. J Vet Pharmacol Ther. 2012 Feb 28.  PubMed PMID: 22372845.

KuKanich B, Bidgood T, Knesl O. Clinical pharmacology of nonsteroidal anti-inflammatory drugs in dogs. Vet Anaesth Analg. 2012 Jan;39(1):69-90. PubMed PMID: 22151877.

Waxman SJ, KuKanich B, Milligan M, Beard WL, Davis EG. Pharmacokinetics of concurrently administered intravenous lidocaine and flunixin in healthy horses. J Vet Pharmacol Ther. 2012 Aug;35(4):413-6. PubMed PMID: 22132770.

Coetzee JF, Edwards LN, Mosher RA, Bello NM, O'Connor AM, Wang B, KuKanich B, Blasi DA. Effect of oral meloxicam on health and performance of beef steers relative to bulls castrated on arrival at the feedlot. J Anim Sci. 2012 Mar;90(3):1026-39. PubMed PMID: 21965454.

Mosher RA, Coetzee JF, Cull CA, Gehring R, KuKanich B. Pharmacokinetics of oral meloxicam in ruminant and preruminant calves. J Vet Pharmacol Ther. 2012 Aug;35(4):373-81. PubMed PMID: 21883284.

KuKanich B, Nauss JL. Pharmacokinetics of the cytochrome P-450 substrates phenytoin, theophylline, and diazepam in healthy Greyhound dogs. J Vet Pharmacol  Ther. 2012 Jun;35(3):275-81. PubMed PMID: 21692812.

Shang Q, Wang X, Apley M, KuKanich SB, Berkland C. PPF microsphere depot sustains NSAID blood levels with infusion-like kinetics without 'burst'. J Vet Pharmacol Ther. 2012 Jun;35(3):231-8. PubMed PMID: 21696401.

Vander Werf KA, Davis EG, KuKanich B. Pharmacokinetics and adverse effects of  oral meloxicam tablets in healthy adult horses. J Vet Pharmacol Ther. 2012 Oct 15. doi: 10.1111/jvp.12021. PubMed PMID: 23067209.