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Kansas State University

Clarenburg Lectures

 

Dr. Arthur Brown

 

Arthur M. Brown
Vice President for Research

The Rammelkamp Center for Education and Research
MetroHealth Medical Center
2500 MetroHealth Drive
Cleveland, OH 44109-1998
 

 

 

 

 

Education:

1956   Medicine
 
MD (Honors)
 
University of Manitoba, Faculty of Medicine, Winnipeg, Canada
 
1964   Physiology 
 
PhD
 
University of London, London, England
 
1995 MA (Oxon., Hon.) University of Oxford Oxford, England

Honors:

Life Insurance Medical Research Fellow, Department of Physiology, Middlesex Hospital Medical School, London, England, 1961-1964

Research Fellow, Cardiovascular Research Institute, University of California Medical Center, San Francisco, CA, 1964-1966

Established Investigator of the American Heart Association, 1967-1972

Josiah Macy Fellow, 1982-1983

Javits Neuroscience Investigator Award, 1978-1984

Alexander von Humboldt Fellow, FRG, 1985-present

The First Annual Daniel A. Nachshen Memorial Lecturer, University of Maryland, 1988

The Harry B. van Dyke Award for Excellence in Medical Research (Pharmacology), Columbia University College of Physicians and Surgeons, 1989

American Physiological Society Walter B. Cannon Lecturer, 1990

Trinity Fellow, New College, Oxford, 1990 (elected)

Robert M. Berne Series in Cardiovascular Sciences Lecturer, 1992

Recipient of American Heart Association Basic Research Prize, 1992

Recipient of the 1993-1994 Louis and Artur Lucian Award for Research in Circulatory Diseases

First Robert M. Berne Distinguished Lecturer of the American Physiological Society Cardiovascular Section

Newton-Abraham Visiting Professor in Medical, Biological and Chemical Sciences for 1995-1996 academic year, University of Oxford, England (elected)

Publications:

Articles in Journals:

Accili, E.A., Kuryshev, Y.A., Wible, B.A. and Brown, A.M. Separable effects of human KvB1.2 – and C-termini on inactivation and expression of human Kv1.4. J. Physiology (1998), 512.2, pp.325-336.

Priori, S., Schwartz, P.J., Napolitano, C., Bianchi, L., Takacs-Dennis, A., De Fusco, M., Brown, A.M., and Casari, G. A recessive variant of the Romano-Ward Long QT syndrome. Circ. 97:2420-2425, 1998.

Dumaine, R., Roy, M-L., and Brown, A.M. Blockade of HERG and Kv1.5 by Ketoconazle1. J. Pharmacol. Exp. Ther. 286:727-735, 1998.

Schwalbe, R.A., Bianchi, L., Accili, E.A., and Brown, A.M. Functional consequences of ROMK mutants linked to antenatal bartter’s syndrome and implications for treatment. Hum. Mol. Genet., 7(6):975-980, 1998.

Kramer, J.W., Post, M.D., Brown, A.M., and Kirsch, G.E. Modulation of potassium channel gating by co-expression of KV2.1 with regulatory Kv5.1 or Kv6.1 " subunits. Amer. J. Physiol: Cell Physiol., 274:C1501-C1510, 1998.

Wible, B.A., Yang, Q., Kuryshev, Y.A., Accili, E.A., and Brown, A.M. Cloning and expression of a novel K+ channel regulatory protein, KchAP. J. Biol. Chem. 273:11745-11751, 1998.

Ficker, E., Jarolimek, W., Kiehn, J., Baumann, A. and Brown, A.M. Molecular determinants of dofetilide block of HERG K+ channels. Circ. Res. 82:386-395, 1998.

Research Activities:

DHHS DK-97-001, "CWRU O’Brien Rental Research Center," 09/01/98-08/31/03. Total: $701,020.

DHHS KL-61642, "Iron-Induced Congestive Heart Failure: New Experimental Model," 09/30/98-09/29/03. Total: $1,420,000.

DHHS HL-55404, "Inward Rectifier K+ channels," 03/08/96-01/31/01. Total: $1,503,707.

DHHS HL-36930, "Membrane Currents in Cardiac Muscle," 08/25/95-07/31/00. Total: $1,125,838.

Additional Information:

54 post-doctoral trainees; 250 articles published in journals; 65 book chapters, several patents.