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Kansas State University

Faculty

 

 

 

 

Jishu Shi

PhD, Immunophysiology, Kansas State University, 1995
MS, Veterinary Immunology, Chinese Academy of Agricultural Sciences, 1988
DVM, Beijing Agricultural University, 1985

Phone (785) 532-4506
e-mail: jshi@vet.k-state.edu

Job Posting – Assistant Scientist

 

 

 

 

Research Interests:

Jishu Shi’s research programs focus on the development of novel vaccine technologies for animal infectious diseases.  His team is currently evaluating novel adjuvants and strategies for vaccines targeting porcine reproductive and respiratory syndrome virus, Mycoplasma hyopneumoniae, swine influenza virus, porcine circovirus, and avian influenza virus.  In addition, his team is also investigating the molecular mechanisms of IL-1beta release from macrophages and the role of IL-1beta in macrophage-cancer stem cell interactions.


Selected publications:

McVey, D.S, and J. Shi. 2010. Vaccines in veterinary medicine: A brief review of history and technology. Veterinary Clinics of North America: Small Animal Practice. 40:381-392.

McVey, D.S, and J. Shi. 2010. Vaccination strategies for emerging disease epidemics of livestock. Veterinary Clinics of North America - Food Animal Practice. 26:173-83.

Wang, L., J. Shi, F.W. van Ginkel, L. Lan, G. Niemeyer, D.R. Martin,E.Y. Snyder, and N.R. Cox. 2009. Neural stem/progenitor cells modulate immune responses by suppressing T lymphocytes with nitric oxide and prostaglandin E2. Experimental Neurology 216:177-183.

Hu, X., C. Ward, S. Aono, L. Lan, C. Dykstra, R. Kemppainen, E. Morrison, and J. Shi. 2008.  Comparative analysis of Xenopus tropicalis hepcidin I and hepcidin II genes.  Gene 426:91-97.

Shi, J. 2007.  Defensins and Paneth cells in inflammatory bowel disease.  Inflammatory Bowel Disease 13:1284-92.

Shi, J., S. Aono, W. Lu, X. Hu, A.J. Ouellette, Y. Ji, L. Wang, S. Lenz, F. van Ginkel, M. Liles, C. Dykstra, E.E. Morrison, and C.O. Elson. 2007.  A novel role for defensins in intestinal homeostasis: regulation of IL-1β secretion.  The Journal of Immunology 179:1245-1253.

Aono, S., C. Li, G. Zhang, R.J. Kemppainen, J. Gard, W. Lu, X. Hu, D.D. Schwartz, E.E. Morrison, C. Dykstra, and J. Shi. 2006.  Molecular and functional characterization of bovine β-defensin-1.  Veterinary Immunology and Immunopathology 113:181-190.

Shi, J. and A.C. Camus. 2006.  Hepcidins in amphibians and fishes: antimicrobial peptides or iron-regulatory hormones?  Developmental and Comparative Immunology 30:746-755.

McVey, D.S.,  J. Shi, J.A. Leigh, E. L. Rosey, P.N. Ward, T.R. Field, and R.J. Yancey. 2005.  Identification of multiple linear epitopes of the plasminogen activator A (PauA) of Streptococcus uberis with murine monoclonal antibodies.  Veterinary Immunology and Immunopathology 104:155-162.

Shi, J., E. Talbot, D. A. DiMattia, and R. G. Dullea. 2004.  The differential effects of IL-1 and TNF-α on proinflammatory cytokines and matrix metalloproteinases expression in human chondrosarcoma cells.  Inflammation Research 53:277-89.

Perregaux, D.G., K. Bhavsar, L. Contillo, J. Shi, and C.A. Gabel. 2002.  Antimicrobial peptides initiate IL-1β posttranslational processing: A novel role beyond innate immunity.  The Journal of Immunology 168:3024-3032.

#Cole, A.M., #Shi, J., A. Ceccareli. Y-H. Kim, A. Park, and T. Ganz. 2001.  Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds.  Blood 97:297-304.  (#authors contributed equally)

Shi, J., G. Zhang, H. Wu, C.R. Ross, F. Blecha, and T. Ganz. 1999.  Porcine epithelial b-defensin-1 is expressed in the dorsal tongue at antimicrobial concentration.  Infection and Immunity 67:3121-3127.

Shi, J. and T. Ganz. 1998. The role of protegrins and other elastase-activated cathelicidins in the bactericidal properties of porcine inflammatory fluids.  Infection and Immunity 66:3611-3617.

Zhang, G., H. Wu, J. Shi, T. Ganz, C.R. Ross, and F. Blecha. 1998.  Molecular cloning and tissue expression of porcine b-defensin-1.  FEBS Letters 424:37-40.

Panyutich, A.V., J. Shi, P.L. Boutz, C. Zhao, and T. Ganz. 1997.  Porcine PMN generate extracellular microbicidal activity by elastase-mediated activation of secreted proprotegrins.  Infection and Immunity 65:978-985.

Shi, J., C.R. Ross, T. L. Leto, and F. Blecha. 1996.  PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p47phox.  Proceedings of the National Academy of Sciences USA 93:6014-6018.