SCHEDULE
August 15-18, 2009
Saturday | Sunday | Monday | Tuesday
Saturday, August 15, 2009
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| 3:00 - 6:00 pm | Registration, Crowne Plaza Resort Foyer, Crystal Ballroom |
| 6:00 pm | Welcome Reception with Dinner Crystal Ballroom, Salons D & E |
| 7:30 pm | Welcome: James Samuel, President, American Society for Rickettsiology
Keynote Address: Salmonella Persistence and Transmission: from Genetic Screens to the Intestinal Microbiota Denise M. Monack, PhD, Assistant Professor in Department of Microbiology and Immunology, Stanford University, School of Medicine, Stanford, CA |
Sunday, August 16, 2009
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| 7:30 – 8:00 am | Poster Session I Set-up |
Host, Vector and Pathogen Interactions |
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| 8:00 am | Obligation Intracellular Bacterium Ehrlichia Inhibiting Mitochondrial Activity Yan Liu, Jiazhi Zhang, Lihong Zhang, David H. Walker, and Xue-jie Yu* |
| 8:15 am | Gene Expression in Neutrophils Infected with the Rickettsial Pathogen Anaplasma phagocytophilum: A role for Autocrine Regulation? |
| 8:30 am | Comparative Growth Kinetics of Rickettsia parkeri Strain Portsmouth and Rickettsia amblyommii Strain Darkwater in Mammalian (Vero) and Tick-derived (ISE6) Cell Lines Apichai Bourchookarn, Walairat Pornwiroon, Natthida Petchampai, and Kevin R. Macaluso* (Abstract #3) |
| 8:45 am | Major Antigen Expression Site Diversity in Anaplasma phagocytophilum Arises from Clustered, Over-represented Functional Pseudogenes Janet E. Foley*, Nathan C. Nieto, Anthony Barbet, and Patrick Foley (Abstract #4) |
| 9:00 am | Dogs (Canis familiaris) as Reservoir Hosts of Rickettsia conorii |
| 9:15 am | Rickettsial Infection in Ticks Parasitizing Wild Birds in Amazon and Atlantic Forest in Brazil. Maria Ogrzewalska, Richard C. Pacheco, Alexandre Uezu, Fernando Ferreira, Marcelo B. Labruna* (Abstract #6) |
| 9:30 am | Coxiella burnetii Subversion of Host Cell Cholesterol |
| 9:45 – 10:15 am | Refreshment Break and Poster Viewing in Poster Session I |
Host, Vector and Pathogen Interactions Continued |
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| 10:15 am | Promoter Analysis of Macrophage- and Tick Cell-specific Differentially Expressed Ehrlichia chaffeensis p28-Omp Genes Lalitha Peddireddi, Chuanmin Cheng and Roman R. Ganta* (Abstract #8) |
| 10:30 am | In vitro Transcriptional Analysis of Ehrlichia chaffeensis Differentially Expressed Genes Bonto Faburay*, Huitao Liu, and Roman Ganta (Abstract #9) |
| 10:45 am | Examination of Ehrlichia chaffeensis Native Tandem Repeat Proteins by Mass Spectrometry Reveals Evidence of Phosphorylation and Absence of Glycosylation Abdul Wakeel*, Xiaofeng Zhang, and Jere W. McBride |
| 11:00 am | Transcriptomic Analysis of Ehrlichia chaffeensis in the Mononuclear Phagocyte Reveals Two Tandem Repeat Proteins are Hyper-Expressed Jeeba A. Kuriakose*, Bing Zhu and Jere W. McBride (Abstract #11) |
| 11:15 am | Bloodmeal Acquisition of Rickettsia felis by Cat Fleas Kathryn E. Reif*, Lane D. Foil and Kevin R. Macaluso (Abstract #12) |
| 11:30 am | Evaluation of the lethal effect of Rickettsia rickettsii on Amblyomma aureolatum ticks Marcelo B. Labruna*, Maria Ogrzewalska, Jonas Moraes-Filho, Thiago F. Martins, Guilherme S. Sabatini (Abstract #13) |
| 11:45 am | The Rickettsial Outer Membrane Protein Sca2 is an Actin Nucleator |
| 12:00 n | Lunch |
| 1:00 – 3:00 pm | Poster Session I (with presenters) Comparative Activity of Pradofloxacin, Enrofloxacin and Azithromycin Against Bartonella henselae Isolates Derived from Cats Silpak Biswas*, Ricardo G. Maggi, Mark G. Papich, Daniel Keil, Edward B. Breitschwerdt (Abstract #16) Expression, Purification and Refolding of Two Fragments (R and Z) of the Outer Membrane Protein A (OmpA) from Rickettsia rickettsii Evaluation of Methods for Establishing Mutations in E. chaffeensis byHomologous Recombination Chuanmin Cheng* and Roman R. Ganta Transcriptional responses of Rickettsia rickettsii exposed to environmental stimuli Tina R. Clark*, Damon W. Ellison, Betsy J. Kleba, Daniel E. Sturdevant, Kimmo Virtaneva, and Ted Hackstadt (Abstract #19) gd T cells suppress protective immunity in chronic but not acute ehrlichiosis. Emily C. Crossley*, Nahed Ismail, David H. Walker (Abstract #20) Purification of DNA from environmental samples: improved DNA yield and quality after sequential use of commercial protocols K.A. Fitzpatrick*, Identification of Diverse Bartonella Genotypes among Small Mammals in Equatorial Africa Vijay A.K.B. Gundi*, Michael Y. Kosoy, Rhodes H. Makundi and Anne Laudisoit (Abstract #22) Evidence of Rickettsioses among patients with Fever and arthritis during the Chikungunya outbreak in Sri Lanka Premaratna, Halambarachchige*, Nanayakkara, Nawasiwatte, Chandrasena, Rajapakse, Bandara, de Silva Transcription profiling of Anaplasma phagocytophilum infected human endothelial cells Michael J. Herron*, Curtis M. Nelson, Ulrike G. Munderloh (Abstract #24) Coxiella burnetii Acid Phosphatase: Inhibiting the Release of Reactive Oxygen Intermediates in Polymorphonuclear leukocytes Joshua Hill* and J.E. Samuel (Abstract #25) Evaluation of rhodamine B as a biomarker for cat fleas, Ctenocephalides felis Supanee Hirunkanokpun*, Kathryn E. Reif, Thomas M. Mascari, Lane D. Foil, and Kevin R. Macaluso (Abstract #26) Coxiella burnetii Phase VariantsReplicate with Similar Kinetics in Degradative Lysosomal Compartments of Human Macrophages Dale Howe*, Jeffrey G. Shannon, David W. Dorward, and Robert A. Heinzen (Abstract #27) OmpR/EnvZ regulates transcription of virulence associated genes in Bartonella henselae Kellie Larsen*, Lisa Smith, Devin Gillaspie, Izabella Perkins, Scott Pangonis, Debra Sweger and Burt Anderson (Abstract #28) Scrub typhus emerging in northern China Shouyin Zhang, Hongbin Song, Yan Liu*, Yong Wang, Jiabin Wu, Junfeng Wan, Guolan Li, Changjun Yu, Xiuyong Li, Qun Li, Wenwu Yin, Zhen Xu, Bo Liu, Qian Zhang, Kanglin Wan, Guichang Li, Xiuping Fu, Jingshan Zhang, Jinrong He, Rong Hai, Dongzheng Yu, David H. Walker, Jianguo Xu, Xue-Jie Yu (Abstract #29) The Trouble with Names: Reporting of Human Anaplasmosis and Ehrlichiosis in Northern States Jennifer McQuiston*, Eric Tongren, Dave Neitzel, Diep Hoang Johnson, Kathleen Gensheimer, Melissa Kemperman, Marina Eremeeva, William Nicholson, John Krebs (Abstract #30) Two paralogous families of Coxiella burnetii Outer Membrane Proteins Comparison of intra-peritoneal versus intra-nasal infection of Coxiella burnetii in mice L. D. Oliver*, J. S. Self, R. A. Priestley, G. J. Kersh, and R. F. Massung (Abstract #32) Comparative antigenic analysis of Amblyomma-associated Rickettsia. Walairat Pornwiroon*, Apichai Bourchookarn, Christopher D. Paddock, Kevin R. Macaluso (Abstract #33) The State of the SNP: Using real-time PCR to genotype Coxiella burnetiiRachael A. Priestley*, Heidie M. Hornstra, Talima Pearson, Paul Keim, and Insertion/Deletion (INDEL) Typing of Isolates of Rickettsia rickettsiiC. Y. Kato, L. K. Robinson*, F. H. White, K. Slater, S. E. Karpathy, M. E. Eremeeva, Placental Infection of Marine Mammals by a Unique Strain of Coxiella burnetii Joshua S. Self*, D.M. Lambourn, T. Baszler, S. Raverty, P. Adem, M.G. Metcalfe, S.R. Zaki, G.J. Kersh, and R.F. Massung (Abstract #36) The Effects of Tick Saliva on the Dendritic Cell-Rickettsia Interaction, In Vitro. T. R. Shelite*, R. Fang, N. Ismail, D. H. Walker (Abstract #37) Use of Dried Blood Spots for Serological Detection of R. felis and R. typhi in Democratic Republic of Congo and Tanzania. Joseph Singleton Jr.*, Linda Cheng, William L. Nicholson, Anne Laudisoit, Nordin S. Zeidner (Abstract #38) Detection of Post-Translational Modifications of Ehrlichial Antigenic Proteins by Eastern Blotting Technique Sunil Thomas*, Emily Crossley, Nagaraja Thirumalapura, and David H. Walker (Abstract #39) Characterization of Gamma Interferon-Mediated Inhibition of Growth of Rickettsia prowazekii in Cultured Mouse Fibroblasts Jenifer Turco* Osteomyelitis in a cat due to Bartonella vinsonii subsp berkhoffii genotype II infection Mrudula Varanat*, Alyssa Travis, William Lee, Ricardo G. Maggi, Sally A. Bissett, Keith E. Linder, Edward B. Breitschwerdt (Abstract #41) Sequence Comparisons and Prevalence of Homologues of the pRam2 and pRam3 Plasmids of Rickettsia amblyommii G. A. Dasch*, Frankie H. White, Kevin Tang, Marcelo B. Labruna, David C. Bruce, A. Chris Munk, J. Chris Detter, and Thomas S. Brettin (Abstract #42) Interactions and Expression Analysis of Ehrlichia chaffeensis Ank200 with Tumor Necrosis Factor Alpha and Other Host Target Genes Associated with Pathobiology Bing Zhu*, Kimberly A. Nethery, Jeeba A. Kuriakose, Abdul Wakeel, Xiaofeng Zhang, and Jere W. McBride (Abstract #43) Investigations of the potential role of Leptotrombidium mites in the transmission of Bartonella species in Thailand Kriangkrai Lerdthusnee, Warinpassorn Leepitakrat, Sucheera Insuan Taweesak Monkanna, Surachai Leepitakrat, Weerayut Chareonsondsermkit, Kwanta Chyapum, Hidenori Kabeya, Michael Kosoy, and Jason H. Richardson (Abstract #138) |
Pathogenesis |
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| 3:00 pm | Comparative susceptibility of C3H/HeN and C3H/HeJ mice to experimental Rickettsia rickettsii infection. Elena Rydkina, Loel C. Turpin, Kelly A. Miller, David J. Silverman, and Sanjeev K. Sahni* (Abstract #44) |
| 3:15 pm | A Role for the Coxiella burnetii Cryptic Plasmid in Host Cell Manipulation Daniel E. Voth*, Uma Sharma, Sergey Konstantinov, George Samoilis, Paul A. Beare, Dale Howe, Raphael H. Valdivia, and Robert A. Heinzen (Abstract #45) |
| 3:30 pm | Defining receptor-ligand interactions in spotted-fever group rickettsia pathogenesis Yvonne G.Y. Chan* and Juan J. Martinez (Abstract #46) |
| 3:45 pm | The Anaplasma phagocytophilum-Occupied Vacuole Hijacks Rab GTPases Bernice Huang, Marci A. Scidmore, and, Jason A. Carlyon* (Abstract #47) |
| 4:00 pm | Anaplasma phagocytophilum AnkA binds AT-rich promoter regions in its control of CYBB transcription. Kristen E. Rennoll-Bankert*, Jose C. Garcia-Garcia and J. Stephen Dumler (Abstract #48) |
| 4:15 pm | Rickettsia typhi possess a putative homolog of phospholipase A2 M. Sayeedur Rahman*, Nicole C. Ammerman, Shane M. Ceraul and Abdu F. Azad (Abstract #49) |
| 4:30 pm | Coxiella modulation of Bcl-x splicing prevents host cell apoptosis |
| 4:45 pm | Free Time |
| 6:00 – 7:00 pm | ASR Business Meeting, Elections, Travel Award Presentations |
| 7:00 pm | Dinner and Evening Reception |
| 10:00 pm | Adjourn for the Day |
Monday, August 17, 2009 |
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| 7:30 – 8:00 am | Continental Breakfast |
| 7:30 – 8:00 am | Poster Session II Set-up |
Clinical Aspects, Diagnosis and Treatment |
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| 8:00 am | Genomic Sequence Variation in the Complete Genome Sequences of Multiple Isolates of Rickettsia rickettsii, R. prowazekii, and R. typhi. G. A. Dasch*, Marina E. Eremeeva, Kathryn G. Dirks, Lauren K. Robinson, Frankie H. White, Cecilia Y. Kato, Sandor E. Karpathy, Kevin Tang, David C. Bruce, A. Chris Munk, J. Chris Detter, Karen W. Davenport, and Thomas S. Brettin (Abstract #50) |
| 8:15 am | Assessment of a quantitative multiplex 5’ nuclease PCR for spotted fever and typhus group rickettsioses, Ehrlichia chaffeensis, and Anaplasma phagocytophilum. Reller ME*, Clemens EG, Prakash JA, Dumler JS |
| 8:30 am | An Update on Rhipicephalus sanguineus-associated Rocky Mountain spotted fever in Eastern Arizona: 2002-2008 Marc Traeger*, Craig Levy, Tasha Stewart, Matthew David, Dwight Humpherys, Joanna Regan, Jennifer McQuiston |
| 8:45 am | Evaluation of Synthetic Ehrlichia chaffeensis Tandem Repeat Immunodeterminants for Serodiagnosis of Human Monocytotropic Ehrlichiosis Tian Luo*, Xiaofeng Zhang, William L. Nicholson, and Jere W. McBride (Abstract #53) |
| 9:00 am | An RNAi screen reveals that host Arp2/3 and Abi/WAVE complexes, but not WASP proteins, are required for Rickettsia parkeri invasion Shawna Reed*, Matthew Welch (Abstract #54) |
| 9:15 am | Efficacy of Doxycycline Treatement in Dogs Naturally Infected with Anaplasma phagocytophilum. Diniz, PPVP*; Correa, MT; Chandrashekar, R; Beall, M; Birkenheuer, A.J; Breitschwerdt, EB (Abstract #55) |
| 9:30 am | Serologic Assessment of the Burden of Rickettsial Infections in Southern Sri Lanka Reller ME*, Clemens EG, Woods CW, Dumler JS (Abstract #56) |
| 9:45 am | New Serological Observations on Rickettsioses in Sri Lanka Premaratna R*, Chandrasena TGAN, Bandara NKBKRGW Rajapakse RPVJ, Ariyaratne NK, Kularatna SAM, Eremeeva ME, Dasch GA, de Silva HJ (Abstract #57) |
| 10:00 am | The Rickettsia conorii autotransporter protein, Sca1 promotes adherence to non-phagocytic mammalian cells Sean P. Riley*, Kenneth G. Goh, Marissa M. Cardwell, Yvonne G.Y. Chan, Timothy M. Hermanas, Juan J. Martinez |
| 10:15 – 12:15 pm | Poster Sessions II A case of person-to-person transmission of Q fever from an active duty serviceman to his spouse Marisa H. Miceli*, Alicia D.Anderson, Andrea Kay Veryser, Diedre Hofinger, Samuel A. Lee and Corey Tancik (Abstract #59) Improvements in Coxiella burnetii genetic transformation Paul A. Beare*, Anders Omsland, Diane C. Cockrell, Seth Winfree, Dale Howe, and The Sca2 autotransporter protein from Rickettsia conorii is sufficient to mediate adherence to and invasion of cultured mammalian cells Bone Marrow Chimeric Mice and Humanized Mice for the Study of Rickettsial Pathophysiology and Immunology Paula Correa, Erika Caro*, and Altered miRNA expression in sera from mice infected by O. tsutsugamushi Chien-Chung Chao*, Erin Huber and Wei-Mei Ching (Abstract #63) Infection with Bartonella vinsonii subsp. berkhoffii genotype I and a novel Bartonella in a dog and owner from Virginia N.A. Cherry*, R.G. Maggi, Characterization of Signal Transducer and Activator of Transcription protein-1 (STAT1) activation during Rickettsia conorii infection of human endothelial cells. Punsiri M. Colonne*, Alicia Clementi, Elena Rydkina, and Sanjeev K. Sahni (Abstract #65) Molecular identification of Rickettsia and Bartonella in Pallac and Ñaupay province of Huaral, Lima-Peru. J. Cutipa.*, S. Radulovic, M. Quevedo, Preliminary Report: An individual-based model of tick-borne disease A note on human and animal rickettsial diseases in Australia Genomic Diversity of Rickettsia felis Sandor E. Karpathy*, Galina E. Zemtsova, Kyle F. Abramowicz, Maria L. Zambrano, Marina E. Eremeeva, and The Impact of Variability among Commercial Serologic Assays and Diagnostic Thresholds on U.S. Surveillance for Tickborne Rickettsial Diseases Antibodies Directed at Tandem Repeat Protein Epitopes Decreases Efficiency of Ehrlichia chaffeensis Infection In Vitro Jeeba A. Kuriakose*, Tian Luo, Xiaofeng Zhang and Jere W. McBride (Abstract #71) Genomic Comparison between the East side agent Rickettsia peacockii and the Rocky Mountain spotted fever agent Rickettsia rickettsii Felsheim RF, The zebrafish embryo as a model for the study of Bartonella henselae infection and host response Amorce Lima*, Jahanshah Amin, Jessica Moore and Burt Anderson (Abstract #73) Human Infections with Zoonotic Bartonella Species in the Coastal Lowlands of Ecuador S.L. Lydy*, M. Lascano, J. Garcia, and M.J. Grijalva (Abstract #74) Rhipicephalus sanguineus-associated Rocky Mountain spotted fever in Mexicali, Mexico: Observations from an outbreak in 2008-2009 Rocio Sanchez, Celia Alpuche, Hugo Lopez-Gatell, Carmen Soria, Julia Estrada, Hector Olguín, Miguel Angel Lezana, William Nicholson, Marina Eremeeva, CDC Infectious Disease Pathology Branch, Greg Dasch, Maureen Fonseca, Sonia Montiel, Stephen Waterman, Jennifer McQuiston* (Abstract #75) Molecular detection of Bartonella henselae and Bartonella koehlerae from aortic valves of boxer dogs with infective endocarditis Danny Morick*, Dan G. Ohad, Boaz Avidor, Shimon Harrus (Abstract #76) Amblyomma imitator: identification of a new vector for Rickettsia rickettsii in South Texas and Mexico. Karla Andrade-Oliveira*, Adriano Pinter, Aaron Medina-Sanchez, Venkata D. Boppana , Stephen K. Wikel , David H. Walker , and Donald H. Bouyer (Abstract #77) Human Infection with Rickettsia felis, Kenya Allen L. Richards*, Ju Jiang, Sylvia Omulo, Daniel R. Feikin, Robert F. Breiman, M. Kariuki Njenga. (Abstract #78) Comparison of the Genome Sequences of Rickettsia canadensis McKiel and CA410 G. A. Dasch, Marina E. Eremeeva, Kimetha Slater*, Frankie H. White, Kevin Tang, Anup Madan, David C. Bruce, A. Chris Munk, J. Chris Detter, and Thomas S. Brettin (Abstract #79) Utilization of real time PCR for quantification of Ehrlichia canis rickettsemia during experimental canine monocytic ehrlichiosis R.T. Stoffel*, J.C. McClure, J.J. Schaefer, S.A. Ewing, and R.W. Stich (Abstract #80) Tissue-specific transcriptional analysis of tick molecules during typical and atypical rickettsial infection Piyanate Sunyakumthorn*, Natthida Petchampai, Walairat Pornwiroon, and Kevin R. Macaluso (Abstract #81) Detection of Rickettsia japonica and Orientia tsutsugamushi by in situ hybridization Keiko Tamakuma*, Mai Itoh, Kazuaki Miyamoto, Kazuya Shiogama, Hirotoshi Utsunomiya, Ken-Ichi Inada, Hiromi Fujita, Fumihiko Mahara, Yutaka Tsutsumi (Abstract #82) Molecular analysis of T-cell repertoire diversity in animal models of persistent and fatal ehrlichiosis Nagaraja R. Thirumalapura*, Sunil Thomas, Lynn Soong and David H. Walker (Abstract #83) Molecular detection of Rickettsia felis and Bartonella henselae in cat fleas (Ctenocephalides felis) on dogs from Taiwan Kun-Hsien Tsai*, Chin-Gi Huang, Wen-Jer WuPei-Yun Shu,and Jyh-Hsiung Huang (Abstract #84) Investigation of Ehrlichia chaffeensis Secreted Tandem Repeat and ANK Proteins in a Type IV Secretion System Model Abdul Wakeel*, Amke den Dulk-Ras,Paul J. J. Hooykaas, and Jere W. McBride (Abstract #85) Transmission of Rickettsia conorii between Cofeeding Rhipicephalus sanguineus Ticks. Galina Zemtsova*, Lindsay Killmaster, Michael L. Levin (Abstract #86) Early Ehrlichia chaffeensis-Monocyte InteractionInduces Response Dominated by Inflammatory CC Family Chemokines Xiaofeng Zhang* and |
| 12:15 pm | Lunch on your Own |
Tuesday, August 18, 2009 |
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| 7:30 – 8:00 am | Continental Breakfast |
| 7:30 – 8:00 am | Poster Session III Set-up |
Ecology, Epidemiology, and Infection in Animals |
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| 8:00 am | Emergence of murine typhus in Austin/Travis County, Texas, USA, 2008 Jennifer Adjemian, Sharyn Parks, Kristina McElroy, Jill Campbell, Marina Eremeeva, William Nicholson, Jennifer McQuiston*, Jeffery Taylor (Abstract #88) |
| 8:15 am | Reservoir competence and ecological role of the redwood chipmunk (Tamias ochrogenys) for Anaplasma phagocytophilum Nathan Nieto*, Janet Foley (Abstract #89) |
| 8:30 am | Genetic analysis of Rickettsia rickettsii and Rhipicephalus sanguineus Latreille from Mexicali, Mexico Marina E. Eremeeva*, Maria L. Zambrano, Lorenza Beati, Gregory A. Dasch, Sandor E. Karpathy, Hector Olguín, Luis Anaya, Beatriz García, Celia M. Alpuche Aranda (Abstract #90) |
| 8:45 am | Prevalence and Distribution of Rickettsia felis in San Bernardino, California Kyle F. Abramowicz*, Joseph W. Wekesa, Chris N. Nwadike, Maria L. Zambrano, Sandor E. Karpathy, Renjie Hu, Marina E. Eremeeva (Abstract #91) |
| 9:00 am | Prevalence of Coxiella burnetii DNA in Environmental Samples Acquired in the United States G.J. Kersh*, T.M. Wolfe, K. Fitzpatrick, J.S. Self, L.D. Oliver, A.A. Kapasi, N.E. Patterson, A.J. Candee, R.A. Priestley and R.F. Massung |
| 9:15 am | United States Surveillance for Rocky Mountain Spotted Fever, 2000-2007: Interpreting Contemporary Increases in Incidence Jennifer H. McQuiston*, John J Openshaw, John W Krebs, Robert C Holman, Eric Mandel, Alexis Harvey, Dana Haberling, David L Swerdlow, and Rob Massung (Abstract #93) |
| 9:30 am | Molecular Detection of Bartonella species in wild rodents and rodents' fleas in Israel using HRM real-time PCR. Danny Morick*, Gad Baneth, Boaz Avidor, Michael Y. Kosoy, Kosta Y. Mumcuoglu, Dvir Mintz, Osnat Eyal, Nahum Shpigel, Shimon Harrus (Abstract #94) |
| 9:45 – 10:15 am | Refreshments and poster viewing in Poster Session III |
Immunity and Vaccine Development |
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| 10:15 am | Role of NK and NKT cells in the development of inflammatory histopathology in the murine model of Anaplasma phagocytophilum infection. DG Scorpio*, SJ Trembleya, KS Choi, and JS Dumler (Abstract #95) |
| 10:30 am | Generation and maintenance of memory T cell responses during persistent ehrlichial infection and the role of CD4+CD25+ T regulatory cells in ehrlichial persistence Nagaraja Thirumalapura*, Emily Crossley, David H. Walker and Nahed Ismail (Abstract #96) |
| 10:45 am | Ehrlichia infection induces IFN gamma-dependent alerations in hematopoietic stem and progenitor cells. Gary Winslow* (Abstract #97) |
| 11:00 am | Natural Killer cells mediate tissue injury and inhibit protective immunity during severe acute murine monocytic ehrlichiosis Stevenson, H.L., Estes, D.M., Thirumalapura, N., Walker, D.H., and N. Ismail* (Abstract #98) |
| 11:15 am | CD4+ CD25+ Foxp3- T regulatory cells produce both IFN-g and IL-10 during severe acute murine spotted fever rickettsiosis Rong Fang*, Nahed Ismail, Thomas Shelite and David H. Walker (Abstract #99) |
| 11:30 am | Diversity of the 47 kDa/HtrA translated amino acid sequences among human isolates of Orientia tsutsugamushi. Ju Jiang, Stuart D. Blacksell, Daniel H. Paris, Nuntipa Aukkanit, Paul N. Newton, Rattanaphone Phetsouvanh, Len Izzard, John Stenos, Stephen R. Graves, Nicholas P.J. Day, Allen L. Richards* (Abstract #100) |
| 11:45 am | Infection of Orientia tsutsugamushi may induce auto-antibody against human serine protease HtrA1 Hua-Wei Chen, Zhiwen Zhang, Erin Huber, Chien-Chung Chao, Hui Wang, Gregory A. Dasch and Wei-Mei Ching* (Abstract #101) |
| 12:00 – 1:00 pm | Lunch |
| 1:00 – 3:00 pm | Poster Session III Functional pseudogene usage in natural infections with Anaplasma phagocytophilum A. F. Barbet*, J.E. Foley, N.C. Nieto, M. Gabriel, B. Al-Khedery, and P. Foley (Abstract #102) A Comparison of Relative Plasmid Copy Numbers for Select Rickettsia Species. Burkhardt, N.B.*, Baldridge, G.D., Kurtti, T.J., Munderloh, U. G. Anaplasma phagocytophilum proteins APH_0032 and APH_1387 associate with the pathogen-occupied vacuolar membrane and are phosphorylated Bernice Huang, Philipp Clark, Matthew J. Troese, Jason A. Carlyon* Characterization of the H-2 I-Ab restricted C. burnetii CD4+ T cell epitopes: intricate linkage between antibody production and CD4+ T cell specificities. Chen Chen*, Courtney Dow, Jun Zhang, James E. Samuel and Bjoern Peters. (Abstract #105) Construction of Ehrlichia muris genomic library for identification of vaccine candidates using murine CD4+ T cell expression cloning Patricia A. Crocquet-Valdes*, Nagaraja R. Thirumalapura, and David H. Walker. (Abstract #106) Evaluation of DnaB Replicative Helicase Gene Family-Based Quantitative PCR Assays for Improved Detection of Orientia tsutsugamushi Christal S. Yim, Sandor E. Karpathy, Marina E. Eremeeva, and Gregory A. Dasch* (Abstract #107) Detection of Rickettsia and Ehrlichia in Ticks and Fleas from the Island of St. Kitts Patrick J Kelly , Kathryn G. Dirks*, Marina E. Eremeeva, Maria L. Zambrano, Tammy Krecek, and Gregory A. Dasch (Abstract #108) Ultrastructural Variations of Ehrlichia chaffeensis in Macrophages and Tick Cells Sarah E. Dedonder, Lloyd Willard, Chuanmin Cheng, and Roman R. Ganta* (Abstract #109) Highly Sensitive and Specific PCR Screening Systems for the Detection and Identification of Rickettsia Marylin Hidalgo, Michal Gazi*, Paula Correa, and Gustavo Valbuena (Abstract #110) Differential cytokine and chemokine production and Toll-like receptor signaling pathways during acute Ehrlichia infection Purnima Ghose*, Rahman Mohammed, Nagaraja Thirumalapura, Billy Ballard, and Nahed Ismail Inexpensive and High Throughput Whole Genome Amplification for Improved Characterization of Rickettsia DNAs C. Y. Kato*, L. K. Robinson, F. H. White, M. E. Eremeeva, G. A. Dasch (Abstract #112) Brazilian spotted fever: serosurvey of domestic animals, evaluation of Rickettsia-infected ticks, and isolation of Rickettsia rickettsii from the tick Rhipicephalus sanguineus. Richard C. Pacheco, Jonas Moraes-Filho, Elizângela Guedes, Iara Silveira1, Leonardo J. Richtzenhain, Romário C. Leite, Marcelo B. Labruna* (Abstract #113) Ellucidation of the interactions between the Host Autophagic Response and the Intracellular Pathogen, Rickettsia prowakii Amanda Lackey* and David O. Wood (Abstract #114) Complementation of a Natural katE Mutation in Coxiella burnetii Nine Mile Enhances Growth in Murine Macrophages. K. Mertens*, J. Berg and J.E. Samuel (Abstract #115) A novel Coxiella burnetii lipoprotein involved in metal binding (LimB). Evidence for an adaptive msp2/p44 recombination mechanism in Anaplasma phagocytophilum Curtis M. Nelson*, Roderick F. Felsheim, Nicole Y. Burkhardt, Ulrike G. Munderloh (Abstract #117) Bartonella sp. Isolates form Woodchucks (Marmota monax) represent a novel taxon William L. Nicholson* and Kelly A. Pierce (Abstract #118) Inhalational Animal Models of Rickettsial Infections Juan P. Olano*, Donald Bouyer, Jacqueline Parker, Gary Wen, Amber Stanford (Abstract #119) Phenotypic changes in Anaplasma phagocytophilum mutants: insights into two genes required for human and tick vector infection Oliva Chávez, A. S.*, Felsheim, R. F., Herron, M., Burkhardt, N., Kurtti, T. J., and Munderloh, U. G. (Abstract #120) The Role of Microtubules and Microfilaments in Spotted fever group Rickettsia invasion of tick host cells Natthida Petchampai*, Chutima Thepparit and Kevin R. Macaluso (Abstract #121) Seroprevalence of Rickettsia typhi and Rickettsia conorii in Tanzania Aubree J. Roche*, William L. Nicholson, Anne B. Morrissey, Habib O. Ramadhani, Venance P. Maro,Grace D. Kinabo, Wilbord Saganda, John A. Crump (Abstract #122) Histone Mediates Rickettsia felis Entry into Ixodes scapularis-Derived ISE6 Cell: The Putative Role of Histone in Rickettsial Cell- Cell Transmission Chutima Thepparit* and Kevin R. Macaluso (Abstract #123) Bartonella; a model intracellular pathogen for developing therapeutics Anaplasma phagocytophilum infects murine mast cells in vitro Nore Ojogun, Bernice Huang, Daniel Miller, Rachael J. Thomas*, Brian Barnstein, John J. Ryan, and Jason A. Carlyon (Abstract #125) Expression and Characterization of A. phagocytophilum Asp55 and Asp62 throughout the Course of Infection in Human Myeloid Cells Matthew J. Troese* Jason A. Carlyon (Abstract #126) Differential Proteomic Analysis of Rickettsia prowazekii Propagated in Diverse Host Backgrounds Aimee M Tucker*, Lonnie O. Driskell, Lewis K. Pannell, Nicolas Verneuil and David O. Wood (Abstract #127) Type II secretion mediated via the type IV pilus of Coxiella burnetii Coxiella burnetii Phase II Induces a Low Level of Apoptosis in an Early Stage of Infection via a Caspase-independent Pathway in Human THP-1 Cells Yan Zhang, Guoquan Zhang*, Laura R. Hendrix and James E. Samuel (Abstract #129) Identification and Mapping of a Variable Carboxy-Terminal Antibody Epitope in the Ehrlichia canis 36-kDa Immunoreactive Tandem Repeat Protein Xiaofeng Zhang*, Michael Yabsley, Avi Keysary, Gad Baneth, and Jere W. McBride |
Genetics, Physiology and Functional Genomics |
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| 3:00 pm | Analysis of Complete Genome Sequence of Neorickettsia risticii: the Causative Agent of Potomac Horse Fever Mingqun Lin, Chunbin Zhang, |
| 3:15 pm | Axenic Growth of the Q Fever Bacterium Coxiella burnetii Anders Omsland*, Diane Cockrell, Dale Howe, Jeffrey G. Shannon, and Robert A. Heinzen |
| 3:30 pm | Characterization of Two Rickettsia prowazekii Phospholipase A Homologues that Exhibit Interesting Activation Profiles Jonathon P. Audia* (Abstract #133) |
| 3:45 pm | Identification of host genes that contribute to Ehrlichia chaffeensis pathogenicity in Drosophila melanogaster Alison Luce-Fedrow*, Tonia Von Ohlen and Stephen K. Chapes (Abstract #134) |
| 4:00 pm | Rickettsiales type IV secretion system diversity correlates with cell envelope adaptions to host environment Joseph Gillespie* |
| 4:15 pm | Expression and localization of Coxiella burnetii (NMII) type IV secretion system protein homologs during infection of host cells John Kent Morgan and Edward I. Shaw* (Abstract #136) |
| 4:30 pm | 23rd Meeting of The American Society for Rickettsiology Adjourned |